Immunohistochemical analysis of interleukin-1α, its type I receptor and antagonist in keratocystic odontogenic tumors

2008 ◽  
Vol 37 (9) ◽  
pp. 560-564 ◽  
Author(s):  
Yoko Suyama ◽  
Yasutaka Kubota ◽  
Tomohiro Ninomiya ◽  
Kanemitsu Shirasuna
Keyword(s):  
Immunohistochemical Analysis ◽  
Odontogenic Tumors ◽  
Type I ◽  
Interleukin 1Α ◽  
Keratocystic Odontogenic Tumors

Comparative Immunohistochemical Analysis of Hmlh1, P63 and MDM-2 Expression in Syndrome and Non-Syndrome Keratocystic Odontogenic Tumors

2015 ◽  
Vol 120 (2) ◽  
pp. e105
Author(s):  
BÁRBARA VANESSA DE BRITO MONTEIRO ◽  
ROBERTA BARROSO CAVALCANTE ◽  
RENATO LUIZ MAIA NOGUEIRA ◽  
MÁRCIA CRISTINA DA COSTA MIGUEL ◽  
CASSIANO FRANCISCO WEEGE NONAKA ◽  
...  
Keyword(s):  
Immunohistochemical Analysis ◽  
Odontogenic Tumors ◽  
Keratocystic Odontogenic Tumors

scholarly journals Correlation Between Radiographic Area and Immunolocation of MMP-2 and MMP-9 in Unilocular Radiographic Lesions

2014 ◽  
Vol 25 (6) ◽  
pp. 466-471
Author(s):  
Rafaela Scariot ◽  
Lucas Caetano Uetanabaro ◽  
Melissa Rodrigues de Araujo ◽  
Joao Zielak ◽  
Allan Fernando Giovanini ◽  
...  
Keyword(s):  
Immunohistochemical Analysis ◽  
Biological Behavior ◽  
Odontogenic Tumors ◽  
Inverse Association ◽  
Bone Cysts ◽  
Maxillofacial Region ◽  
Pathological Conditions ◽  
Dentigerous Cysts ◽  
Ellipse Area ◽  
Keratocystic Odontogenic Tumors

Unilocular bone cysts are the most common entities affecting the maxillofacial region. The mechanism of proliferation and expansion remains unclear. Metalloproteinases (MMPs) are associated to diverse pathological conditions. The aim of the present study was to correlate the radiographic aspect (area) and the presence of MMP-2 and MMP-9 in dentigerous cysts, radicular cysts and keratocystic odontogenic tumors. The radiographic area of each lesion was calculated using the mathematical formula of the ellipse area. All specimens were subjected to immunohistochemical analysis for these enzymes. The average radiographic area was 284.17 mm2, 235.81 mm2 and 381.81 mm2, respectively. Statistical analyses revealed no association between the immunoreactivity of MMPs and radiographic area of the lesions in all pathologies studied, except for MMP-2 and radicular cysts, for which smaller lesions had increased immunostaining for this enzyme. The results demonstrate that quantities of MMP-2 and MMP-9 are especially involved with dentigerous and radicular cysts in expansion, whereas these enzymes seem to be related to the biological behavior of keratocystic odontogenic tumors, indicating invasion and cell proliferation. Moreover, there is an inverse association between MMP-2 and MMP-9 in keratocystic odontogenic tumors (p=0.03; rs=-0.660), indicating activity in different regions.

Immunohistochemical Analysis of Glucose Transporter-1 Expression and Angiogenic Index in Syndrome and Non-Syndrome Keratocystic Odontogenic Tumors

2015 ◽  
Vol 120 (2) ◽  
pp. e94
Author(s):  
RAFAELLA BASTOS LEITE ◽  
ROBERTA BARROSO CAVALCANTE ◽  
RENATO LUIZ MAIA NOGUEIRA ◽  
LÉLIA BATISTA DE SOUZA ◽  
LEÃO PEREIRA PINTO ◽  
...  
Keyword(s):  
Glucose Transporter ◽  
Immunohistochemical Analysis ◽  
Odontogenic Tumors ◽  
Glucose Transporter 1 ◽  
Keratocystic Odontogenic Tumors

scholarly journals Expression of interleukin-1α and interleukin-1 receptor type I genes in murine brown adipose tissue

FEBS Letters ◽  
1993 ◽  
Vol 334 (2) ◽  
pp. 229-232 ◽  
Author(s):  
Ladislav Burýs̆ek ◽  
Petr Tvrdí ◽  
Josef Hous̆tĕk
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Interleukin 1 ◽  
Receptor Type ◽  
Type I ◽  
Brown Adipose ◽  
Interleukin 1Α

scholarly journals CD1a-positive Langerhans cells and their relationship with E-cadherin in ameloblastomas and keratocystic odontogenic tumors

2012 ◽  
Vol 42 (6) ◽  
pp. 454-461 ◽  
Author(s):  
Leonardo Araújo Mello ◽  
Andréia Leal Figueiredo ◽  
Eduardo Antônio Gonçalves Ramos ◽  
Clarissa Araújo Silva Gurgel ◽  
Manoela Domingues Martins ◽  
...  
Keyword(s):  
Langerhans Cells ◽  
Odontogenic Tumors ◽  
Keratocystic Odontogenic Tumors ◽  
E Cadherin

scholarly journals Intracellular Interleukin-1α Mediates Interleukin-8 Production Induced by Chlamydia trachomatis Infection via a Mechanism Independent of Type I Interleukin-1 Receptor

2007 ◽  
Vol 76 (3) ◽  
pp. 942-951 ◽  
Author(s):  
Wen Cheng ◽  
Pooja Shivshankar ◽  
Youmin Zhong ◽  
Ding Chen ◽  
Zhongyu Li ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Early Stage ◽  
Interleukin 1 ◽  
Type I ◽  
Infection Cycle ◽  
Chlamydia Trachomatis Infection ◽  
Cytokines And Chemokines ◽  
Intracellular Mechanism ◽  
Interleukin 1Α ◽  
Interfering Rna

ABSTRACT Chlamydia trachomatis infection induces a wide array of inflammatory cytokines and chemokines, which may contribute to chlamydia-induced pathologies. However, the precise mechanisms by which Chlamydia induces cytokines remain unclear. Here we demonstrate that the proinflammatory cytokine interleukin-1α (IL-1α) plays an essential role in chlamydial induction of the chemokine IL-8. Cells deficient in IL-1α expression or IL-1α-competent cells treated with IL-1α-specific small interfering RNA failed to produce IL-8 in response to chlamydial infection. However, neutralization of extracellular IL-1α or blockade of or deficiency in type I IL-1 receptor (IL-1RI) signaling did not affect chlamydial induction of IL-8 in cells capable of producing IL-1α. These results suggest that IL-1α can mediate the chlamydial induction of IL-8 via an intracellular mechanism independent of IL-1RI, especially during the early stage of the infection cycle. This conclusion is further supported by the observations that expression of a transgene-encoded full-length IL-1α fusion protein in the nuclei enhanced IL-8 production and that nuclear localization of chlamydia-induced precursor IL-1α correlated with chlamydial induction of IL-8. Thus, we have identified a novel mechanism for chlamydial induction of the chemokine IL-8.

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