Opinions on Treatment of Women With Habitual Abortion Based on Investigations for Blocking Antibody and Autoantibodies

1991 ◽  
Vol 26 (1) ◽  
pp. 32-37 ◽  
Author(s):  
A. MARGARETA UNANDER ◽  
RENEE NORBERG ◽  
LEOPOLD ÅRFORS ◽  
ANDERS ENSKOG ◽  
MAGNUS HAEGER ◽  
...  
Keyword(s):  
Blocking Antibody ◽  
Habitual Abortion

Does Enoxaparin treatment have any effects on the placenta in women with unexplained histories of habitual abortion? A case control study

2020 ◽  
Vol 138 (4) ◽  
pp. 275-281
Author(s):  
Ayse Zehra Ozdemir ◽  
Bulent Ayas ◽  
Adem Kocaman ◽  
Mesut Önal ◽  
Gülnur Döğenci ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Habitual Abortion ◽  
Control Study

scholarly journals SARS-CoV-2 Entry: At the Crossroads of CD147 and ACE2

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1434
Author(s):  
Claudio Fenizia ◽  
Silvia Galbiati ◽  
Claudia Vanetti ◽  
Riccardo Vago ◽  
Mario Clerici ◽  
...  
Keyword(s):  
Underlying Mechanism ◽  
Membrane Receptors ◽  
Host Cells ◽  
Viral Agent ◽  
Blocking Antibody ◽  
Angiotensin Converting Enzyme 2 ◽  
Host Membrane ◽  
B Virus ◽  
Immunodeficiency Virus

In late 2019, the betacoronavirus SARS-CoV-2 was identified as the viral agent responsible for the coronavirus disease 2019 (COVID-19) pandemic. Coronaviruses Spike proteins are responsible for their ability to interact with host membrane receptors and different proteins have been identified as SARS-CoV-2 interactors, among which Angiotensin-converting enzyme 2 (ACE2), and Basigin2/EMMPRIN/CD147 (CD147). CD147 plays an important role in human immunodeficiency virus type 1, hepatitis C virus, hepatitis B virus, Kaposi’s sarcoma-associated herpesvirus, and severe acute respiratory syndrome coronavirus infections. In particular, SARS-CoV recognizes the CD147 receptor expressed on the surface of host cells by its nucleocapsid protein binding to cyclophilin A (CyPA), a ligand for CD147. However, the involvement of CD147 in SARS-CoV-2 infection is still debated. Interference with both the function (blocking antibody) and the expression (knock down) of CD147 showed that this receptor partakes in SARS-CoV-2 infection and provided additional clues on the underlying mechanism: CD147 binding to CyPA does not play a role; CD147 regulates ACE2 levels and both receptors are affected by virus infection. Altogether, these findings suggest that CD147 is involved in SARS-CoV-2 tropism and represents a possible therapeutic target to challenge COVID-19.

scholarly journals The synonymous 903C>G mutation in the alpha 1,4-galactosyltransferase gene in a Chinese woman with habitual abortion

Medicine ◽  
2019 ◽  
Vol 98 (31) ◽  
pp. e16361 ◽  
Author(s):  
Xiaoying Lv ◽  
Yongquan Chen ◽  
Yuanyuan Luo ◽  
Lingbo Li ◽  
Houzhao Wang
Keyword(s):  
Chinese Woman ◽  
Habitual Abortion

Habitual abortion

1958 ◽  
Vol 75 (2) ◽  
pp. 462
Author(s):  
Cornel Berenkey
Keyword(s):  
Habitual Abortion

scholarly journals Pak1 regulates branching morphogenesis in 3D MDCK cell culture by a PIX and β1-integrin-dependent mechanism

2010 ◽  
Vol 299 (1) ◽  
pp. C21-C32 ◽  
Author(s):  
Michael P. Hunter ◽  
Mirjam M. Zegers
Keyword(s):  
Cell Culture ◽  
Mdck Cell ◽  
Three Dimensional ◽  
3D Culture ◽  
Branching Morphogenesis ◽  
Dominant Negative ◽  
Β1 Integrin ◽  
Blocking Antibody ◽  
Important Regulator ◽  
P21 Activated Kinase

Branching morphogenesis is a fundamental process in the development of the kidney. This process gives rise to a network of ducts, which form the collecting system. Defective branching can lead to a multitude of kidney disorders including agenesis and reduced nephron number. The formation of branching tubules involves changes in cell shape, cell motility, and reorganization of the cytoskeleton. However, the exact intracellular mechanisms involved are far from understood. We have used the three-dimensional (3D) Madin-Darby canine kidney (MDCK) cell culture system to study how p21-activated kinase 1 (Pak1), which is an important regulator of the cytoskeleton, modulates branching. Our data reveal that Pak1 plays a crucial role in regulating branching morphogenesis. Expression of a dominant-negative Pak1 mutant (DN-Pak1) in MDCK cysts resulted in the spontaneous formation of extensions and branching tubules. Cellular contractility and levels of phosphorylated myosin light chain (pMLC) were increased in DN-Pak1 cells in collagen. Expression of a DN-Pak1 mutant that does not bind to PIX (DN-Pak1-ΔPIX) failed to form extensions in collagen and did not have increased contractility. This shows that the DN-Pak1 mutant requires PIX binding to generate extensions and increased contractility in 3D culture. Furthermore, a β1-integrin function-blocking antibody (AIIB2) inhibited the formation of branches and blocked the increased contractility in DN-Pak1 cysts. Taken together, our work shows that DN-Pak1-induced branching morphogenesis requires PIX binding and β1-integrin signaling.

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