NK Cell Function in the Human Female Reproductive Tract

2007 ◽  
Vol 57 (2) ◽  
pp. 108-115 ◽  
Author(s):  
Charles L. Sentman ◽  
Charles R. Wira ◽  
Mikael Eriksson
Keyword(s):  
Reproductive Tract ◽  
Cell Function ◽  
Nk Cell ◽  
Female Reproductive Tract ◽  
Human Female

scholarly journals Expansion of CD16-Negative Natural Killer Cells in the Peripheral Blood of Patients with Metastatic Melanoma

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Shernan G. Holtan ◽  
Douglas J. Creedon ◽  
Michael A. Thompson ◽  
Wendy K. Nevala ◽  
Svetomir N. Markovic
Keyword(s):  
Nk Cells ◽  
Metastatic Melanoma ◽  
Natural Killer ◽  
Transforming Growth Factor Beta ◽  
Peripheral Blood ◽  
Reproductive Tract ◽  
Transforming Growth Factor ◽  
Cell Function ◽  
Nk Cell ◽  
Female Reproductive Tract

Altered natural killer (NK) cell function is a component of the global immune dysregulation that occurs in advanced malignancies. Another condition associated with altered NK homeostasis is normal pregnancy, where robust infiltration with CD16− CD9+ NK cells can be identified in decidual tissues, along with a concomitant expansion of CD16− NK cells in the maternal peripheral blood. In metastatic melanoma, we identified a similar expansion of peripheral blood CD16− NK cells (median 7.4% in 41 patients with melanoma compared with 3.0% in 29 controls,P<.001). A subset of NK cells in melanoma patients also expresses CD9, which is characteristically expressed only on NK cells within the female reproductive tract. Expansion of CD16− NK cells was associated with elevated plasma transforming growth factor-beta (TGF-βlevels (median 20 ng/ml, Spearman'sρ=0.81,P=.015)). These findings suggest the possibility of exploring anti-TGF-βtherapy to restore NK function in melanoma.

Effect of Contraceptive Steroids on the Endometrium of Guinea Pig: SEM study

1977 ◽  
Vol 35 ◽  
pp. 668-669
Author(s):  
Mai M. Said ◽  
Ramesh K. Nayak ◽  
Randall E. McCoy
Keyword(s):  
Guinea Pig ◽  
Reproductive Tract ◽  
Three Dimensional ◽  
Female Reproductive Tract ◽  
Human Female ◽  
Surface Ultrastructure ◽  
Transmission Electron ◽  
Sem Study ◽  
Uterine Mucosa ◽  
Group 1

Burgos and Wislocki described changes in the mucosa of the guinea pig uterus, cervix and vagina during the estrous cycle investigated by transmission electron microscopy. More recently, Moghissi and Reame reported the effects of progestational agents on the human female reproductive tract. They found drooping and shortening of cilia in norgestrel and norethindrone- treated endometria. To the best of our knowledge, no studies concerning the effects of mestranol and norethindrone given concurrently on the three-dimensional surface features on the uterine mucosa of the guinea pig have been reported. The purpose of this study was to determine the effect of mestranol and norethindrone on surface ultrastructure of guinea pig uterus by SEM.Seventy eight animals were used in this study. They were allocated into two groups. Group 1 (20 animals) was injected intramuscularly 0.1 ml vegetable oil and served as controls.

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