Endothelial function in children with a history of premature prolonged rupture of membranes and bronchopulmonary dysplasia – a pilot study

2008 ◽  
Vol 97 (7) ◽  
pp. 909-914 ◽  
Author(s):  
Magnus Liljedahl ◽  
Helena Martin ◽  
Anders Magnuson ◽  
Scott M Montgomery ◽  
Jens Schollin
Keyword(s):  
Pilot Study ◽  
Endothelial Function ◽  
Bronchopulmonary Dysplasia ◽  
History Of

667 Effects of Sleep-Extend on glucose metabolism in women with a history of gestational diabetes: A pilot study

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A261-A261
Author(s):  
Sirimon Reutrakul ◽  
Pamela Martyn-Nemeth ◽  
Laurie Quinn ◽  
Kirstie Danielson ◽  
Brett Rydzon ◽  
...  
Keyword(s):  
Physical Activity ◽  
Pilot Study ◽  
Glucose Metabolism ◽  
Gestational Diabetes ◽  
Sleep Duration ◽  
Control Group ◽  
Healthy Living ◽  
Short Sleep ◽  
History Of ◽  
Sleep Extension

Abstract Introduction Experimental and epidemiological data have linked insufficient sleep to increased diabetes risk. Women with a history of gestational diabetes (GDM) have a 7-fold greater risk of developing type 2 diabetes. This pilot study explored the feasibility of a sleep extension intervention in women with a history of GDM and short sleep, and the effects on glucose metabolism. Methods Women age 18–45 years with a history of GDM (at least 1 year postpartum) and actigraphy confirmed short sleep duration (<7h/night) on weekdays were randomized at a ratio of 1 control (healthy living information) to 2 cases (6 weeks of “Sleep Extend” intervention: use of a Fitbit, weekly digital content, interactive tools, and coach delivered feedback in order to increase sleep duration). An oral glucose tolerance test (OGTT), 7-day actigraphy recording and questionnaires were obtained at baseline and 6 weeks (at the end of the intervention). Results Twelve women (mean (SD) age 40.3 (4.5) years) participated (n=8 Sleep Extend, n=4 control). Compared to baseline, nightly sleep duration increased in Sleep Extend group (+30.6 (48.8) minutes) but decreased in the control group (-6.8 (22.9) minutes). Both fasting and 2-h glucose levels from OGTT increased in both groups but were greater in the control group (Sleep extend vs. healthy living: fasting glucose +2.1 (9.8) vs. +12.8 (7.3) mg/dL; 2-h glucose +8.2 (21.9) vs. +20.0 (19.4) mg/dL). Self-reported sleep quality improved in both groups. When compared controls, Sleep Extend participants reported improved fatigue symptoms (Promis fatigue score change -5.1 (9.3) vs. 7.0 (1.0), p=0.008), and self-reported physical activity tended to increase (+1614 (3659) vs. -2900 (3922) MET-minutes/week). Combining all participants, an increase in sleep duration correlated with a decrease in fatigue (r= -.62, p=0.04) and anxiety symptoms (r= -.69, p=0.02). Conclusion Sleep extension through coaching and use of remote monitoring is feasible in women with a history of GDM. It appears to decrease fatigue and may improve glucose metabolism and physical activity. Support (if any) NIDDK P30 DK092949

P-EP015. Relationship between polymorphism scn1a and history of status epilepticus in epileptic patient: Pilot study

2021 ◽  
Vol 132 (8) ◽  
pp. e83
Author(s):  
Atitya Fithri Khairani ◽  
Sri Sutarni ◽  
Rusdy Ghazali Malueka ◽  
Eti Nurwening Sholikhah ◽  
Audiza Luthffia ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Pilot Study ◽  
Epileptic Patient ◽  
History Of

scholarly journals Clinical Assessment of Endothelial Function in Convalescent COVID-19 Patients Undergoing Multidisciplinary Pulmonary Rehabilitation

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 614
Author(s):  
Pasquale Ambrosino ◽  
Antonio Molino ◽  
Ilenia Calcaterra ◽  
Roberto Formisano ◽  
Silvia Stufano ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Pulmonary Rehabilitation ◽  
Pulmonary Function Tests ◽  
Care Facility ◽  
Forced Expiratory Volume ◽  
Vascular Events ◽  
Inclusion Study ◽  
History Of ◽  
Dependent Flow

Background: Growing evidence points to a key role of endothelial dysfunction in the pathogenesis of COVID-19. In this study, we evaluated changes in endothelium-dependent flow-mediated dilation (FMD) in a cohort of convalescent COVID-19 patients undergoing pulmonary rehabilitation (PR). Methods: After swab test negativization, convalescent COVID-19 patients referring to a post-acute care facility for PR were consecutively screened for inclusion. Study procedures were performed at the time of hospitalization and discharge. Results: We enrolled 82 convalescent COVID-19 patients (85.4% males, mean age 60.4 years). After PR, a significant improvement in most pulmonary function tests and exercise capacity was documented. FMD changed from 2.48% ± 2.01 to 4.24% ± 2.81 (p < 0.001), corresponding to a 70.9% increase. Significantly higher changes in FMD were found in patients without a history of vascular events as compared to those with (+2.04% ± 2.30 vs. +0.61% ± 1.83, p = 0.013). Values of forced expiratory volume in 1 s (FEV1%), forced vital capacity (FVC%) and diffusion capacity for carbon monoxide (DLCO%) significantly and directly correlated with FMD both at baseline and after PR. Patients with normal FEV1% (≥80% predicted) during the overall study period or those normalizing FEV1% after PR showed a more significant FMD change as compared to patients with persistently impaired FEV1% (<80% predicted) (p for trend = 0.029). This finding was confirmed in a multivariate analysis. Conclusions: Clinically evaluated endothelial function improves after PR in convalescent COVID-19 patients. A direct and persistent association between the severity of pulmonary and vascular disease can be hypothesized. Endothelial function testing may be useful in the follow-up of convalescent COVID-19 patients.

scholarly journals A pilot study of the effect of atorvastatin on endothelial function and albuminuria in sickle cell disease

2019 ◽  
Vol 94 (11) ◽  
Author(s):  
Kenneth I. Ataga ◽  
David Wichlan ◽  
Laila Elsherif ◽  
Vimal K. Derebail ◽  
Adane F. Wogu ◽  
...  
Keyword(s):  
Pilot Study ◽  
Sickle Cell Disease ◽  
Endothelial Function ◽  
Sickle Cell ◽  
Cell Disease

scholarly journals A pilot study investigating the relationship between heart rate variability and blood pressure in young adults at risk for cardiovascular disease

2022 ◽  
Vol 28 (1) ◽  
Author(s):  
Linda P. Bolin ◽  
Amelia D. Saul ◽  
Lauren L. Bethune Scroggs ◽  
Carolyn Horne
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Pilot Study ◽  
Family History ◽  
Diastolic Blood Pressure ◽  
Biofeedback Training ◽  
Paced Breathing ◽  
History Of

Abstract Background Cardiovascular disease is one of the leading causes of death globally with hypertension being a primary cause of premature death from this disease process. Individuals with a family history of cardiovascular disease and hypertension are at a greater risk for developing the same sequela. Autonomic cardiac control is important in the level of cardiac function. One intervention that is effective in improving cardiovascular function is heart rate variability biofeedback training. The purpose of our study was to determine the effectiveness of heart rate biofeedback training on HRV and blood pressure in individuals with a family history of cardiovascular disease. Methods Thirty-four participants (76.5% female, 22.7 ± 4.3 years) completed a baseline assessment and training using an established short-term HRV protocol followed by two weeks of at-home paced breathing employing a smartphone application. The participants were then reassessed in a biofeedback clinic. Results The participants physiological measures showed a significant increase in means between pre and post intervention of SDNN (t (32) = 2.177, p =.037) and TP, (t (32) = 2.327 p = .026). Correlation noted a medium effect on diastolic blood pressure and high frequency heart rate variability, F, r = .41, n =33, p < .05. A multiple regression with all predictor variables in the model found no significance with diastolic and systolic blood pressure. Conclusions The findings from this pilot study demonstrated that a two-week paced breathing intervention may assist in reducing heart rate and diastolic blood pressure while improving heart rate variability.

The Feminist Perspective and Social Work Education

2010 ◽  
Vol 15 (1) ◽  
pp. 1-13
Author(s):  
Isabel Rose ◽  
Daria Hanssen
Keyword(s):  
Social Work ◽  
Pilot Study ◽  
Social Work Education ◽  
Feminist Perspective ◽  
Student Responses ◽  
Social Work Educators ◽  
History Of ◽  
Work Education ◽  
History Of Social Work

Although the feminist perspective has been significant throughout the history of social work, its presence in the contemporary profession seems less prominent. This qualitative pilot study explores the views of social work educators (N=56) on the role of the feminist perspective in social work education and their experience with student responses regarding the tenets of feminism as applied to social work education and practice. Although a majority of respondents expressed support for integrating feminism into the curriculum, some sought guidance on the presentation of the feminist perspective in social work education and practice. In addition, an analysis of social work scholarly periodicals for feminist topics and perspectives revealed an apparent fading of feminism in the literature.

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