STUDIES OF THE ANTIGENIC STRUCTURE OF TRICHOPHYTON RUBRUM, TRICHOPHYTON MENTAGROPHYTES, MICROSPORON CANIS, AND EPIDERMOPHYTON FLOCCOSUM BY CROSSED IMMUNO-ELECTROPHORESIS

2009 ◽  
Vol 84C (4) ◽  
pp. 337-341
Author(s):  
AAGE HEIN CHRISTIANSEN ◽  
ELSE SVEJGAARD
Keyword(s):  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Antigenic Structure ◽  
Epidermophyton Floccosum

scholarly journals Antifungal activity and mechanism of heat-transformed ginsenosides from notoginseng against Epidermophyton floccosum, Trichophyton rubrum, and Trichophyton mentagrophytes

RSC Advances ◽  
2017 ◽  
Vol 7 (18) ◽  
pp. 10939-10946 ◽  
Author(s):  
Peng Xue ◽  
Xiushi Yang ◽  
Xiaoyan Sun ◽  
Guixing Ren
Keyword(s):  
Antifungal Activity ◽  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Epidermophyton Floccosum ◽  
Heat Transformation

The improved antifungal activity of notoginseng can be attributed to the formation of less polar ginsenosides by heat transformation.

scholarly journals Frecuencia de dermatomicosis y factores asociados en población vulnerable de la ciudad de Manizales. Colombia. 2011

2016 ◽  
Vol 18 (6) ◽  
pp. 953
Author(s):  
Gloria Ines Estrada Salazar ◽  
José A. Chacón-Cardona
Keyword(s):  
Candida Albicans ◽  
Trichophyton Rubrum ◽  
Culture Media ◽  
Trichophyton Mentagrophytes ◽  
Direct Analysis ◽  
Microsporum Gypseum ◽  
Epidermophyton Floccosum ◽  
Palabras Clave ◽  
Fusarium Sp ◽  
Cutaneous Mycosis

Resumen:Objetivo: Determinar la frecuencia de las dermatomicosis en personas de diferentes instituciones de atención social en la ciudad de Manizales durante el año 2011. Método: Mediante la toma de muestras de los sitios que presentaban algún tipo de lesión sospechosa de ser una micosis cutánea, se hizo un análisis directo con KOH y cultivo en medios de Saboureaud y Mycosel. Se aplicó un instrumento de recolección de información para establecer  factores asociados con la presencia de estos microorganismos.Resultados: Los hongos levaduriformes encontrados con mayor frecuencia fueron: Candida albicans, Trichosporon sp, y los mohos saprofitos Penicillium sp, fusarium sp; seguido de hongos dermatofitos como: Trichophyton mentagrophites, Trichophyton rubrum, Epidermophyton floccosum y Microsporum gypseum. Las lesiones secas y descamativas se encontraron con mayor frecuencia. El compartir baños y vivir en hacinamiento y el uso de elementos comunes fueron los factores asociados más importantes en este estudio.Conclusiones. Las dermatomicosis son frecuentes en poblaciones vulnerables y se asocian a diferentes factores muy similares a los encontrados en otros estudios de igual naturaleza.    Palabras clave: dermatomicosis, onicomicosis, jóvenes, ancianos, factores asociados. Summary:Objective: To determine the frequency of ringworm in people of different social care institutions in the city of Manizales in 2011.Method: Using the sampling sites that had some kind of suspicious lesion from a cutaneous mycosis, direct analysis with KOH and culture media was Saboureaud and Mycosel. An instrument of data collection was used to establish factors associated with the presence of these microorganisms.Results: The yeast found most frequently were: Candida albicans, Trichosporon sp and Penicillium molds saprophytes sp, Fusarium sp, followed by dermatophyte fungi such as Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum and Microsporum gypseum. Dry scaly lesions were found more frequently. The shared bathrooms and living in overcrowded and the use of common elements were the most important in this study associated factors.Conclusions: Dermatomycoses are common in vulnerable populations and are associated with different very similar to those found in other studies of the same nature factors. Keywords: ringworm, onychomycosis, young, old, associated factors.

Pattern of dermatophyte in Bangabandhu Sheikh Mujib Medical University

2012 ◽  
Vol 6 (2) ◽  
pp. 11-14 ◽  
Author(s):  
Mst. Rummana Rahim ◽  
Ahmed Abu Saleh ◽  
Md. Ruhul Amin Miah ◽  
Shaheda Anwar ◽  
Md. Muzibur Rahman
Keyword(s):  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Age Group ◽  
Female Ratio ◽  
Epidermophyton Floccosum ◽  
Tinea Unguium ◽  
Medical University ◽  
Male To Female ◽  
Dermatophyte Species ◽  
Culture Positive

Dermatophytes are by far the most significant fungi because of their widespread involvement of population at large and their prevalence all over the world. This is an attempt to observe the spectrum of dermatophytes among the clinically suspected cases of dermatophytosis attending the outpatient department of Dermatology and Venereology, Bangabandhu Sheik Mujib Medical University, Dhaka. Three hundred and twenty clinically suspected cases of dermatophytosis were subjected to mycological studies. One hundred and five cases (32.8%) were positive for fungus in direct microscopy while 97(30.3%) were culture positive. Tinea unguium was the most common clinical type encountered followed by tinea corporis. Dermatophytosis was more common in the age group of 21-30 years. The male to female ratio was 1.54:1. Trichophyton rubrum 84(86.6%) was found common etiological dermatophyte species followed by Trichophyton mentagrophytes 8(8.2%) and Epidermophyton floccosum 5(5.2%).DOI: http://dx.doi.org/10.3329/bjmm.v6i2.19370 Bangladesh J Med Microbiol 2012; 06(02): 11-14

scholarly journals Sertaconazole Nitrate Shows Fungicidal and Fungistatic Activities against Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, Causative Agents of Tinea Pedis

2011 ◽  
Vol 55 (9) ◽  
pp. 4420-4421 ◽  
Author(s):  
Alfonso J. Carrillo-Muñoz ◽  
Cristina Tur-Tur ◽  
Delia C. Cárdenes ◽  
Dolors Estivill ◽  
Gustavo Giusiano
Keyword(s):  
Tinea Pedis ◽  
Fungicidal Activity ◽  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Clinical Isolates ◽  
Geometric Means ◽  
Epidermophyton Floccosum ◽  
Content Type ◽  
Causative Agents

ABSTRACTThe fungistatic and fungicidal activities of sertaconazole against dermatophytes were evaluated by testing 150 clinical isolates of causative agents of tinea pedis,Trichophyton rubrum,Trichophyton mentagrophytes, andEpidermophyton floccosum. The overall geometric means for fungistatic and fungicidal activities of sertaconazole against these isolates were 0.26 and 2.26 μg/ml, respectively, although values were higher forT. mentagrophytesthan for the others. This is the first comprehensive demonstration of the fungicidal activity of sertaconazole against dermatophytes.

scholarly journals Antifungal Activity of Eugenia umbelliflora against Dermatophytes

2009 ◽  
Vol 4 (9) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Karina E. Machado ◽  
Valdir Cechinel Filho ◽  
Rosana C. B. Cruz ◽  
Christiane Meyre-Silva ◽  
Alexandre Bella Cruz
Keyword(s):  
Antifungal Activity ◽  
Betulinic Acid ◽  
Fungal Pathogens ◽  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Microsporum Canis ◽  
Microsporum Gypseum ◽  
Epidermophyton Floccosum ◽  
Agar Dilution

Antifungal activities of Eugenia umbelliflora Berg. (Myrtaceae) were tested in vitro against a panel of standard and clinical isolates of human fungal pathogens (dermatophytes and opportunistic saprobes). Methanol extracts of leaves and fruits of E. umbelliflora were separately prepared and partitioned, to yield dichloromethane (DCM), ethyl acetate (EtOAc) and aqueous fractions (Aq). Three compounds (1-3) were obtained from the DCM extract using chromatographic procedures. Antifungal assays were performed using agar dilution techniques. Both extracts (fruits and leaves), their DCM and EtOAc fractions, and compound 2 (betulin and betulinic acid) presented selective antifungal activity against dermatophytes (Epidermophyton floccosum, Microsporum canis, Microsporum gypseum, Trichophyton rubrum, Trichophyton mentagrophytes), with MIC values between 200 and 1000 μg/mL, and interestingly, inhibited 4/5 species with MIC values of ≤500 ≤g/mL. The aqueous fractions of fruits and leaves, and compounds 1 (α, β amyrin) and 3 (taraxerol) were inactive up to the maximum concentrations tested (1000 μg/mL).

scholarly journals Evaluación de la sensibilidad de hongos dermatofitos aislados de muestras clínicas a los antifúngicos

2020 ◽  
pp. 101-106
Author(s):  
Beda E. Mereles Rodríguez ◽  
Jacqueline N. Fiedler ◽  
Azucena Bruquetas ◽  
Miriam E. Chade
Keyword(s):  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Microsporum Canis ◽  
Trichophyton Tonsurans ◽  
Epidermophyton Floccosum

Los dermatofitos causan infecciones que en ocasiones no responden adecuadamente al tratamiento antifúngico implementado, sin embargo, se han publicado muy pocos estudios de sensibilidad a nivel mundial. El objetivo de este trabajo fue evaluar in vitro, la sensibilidad de hongos dermatofitos aislados de muestras clínicas frente a tres antifúngicos de uso habitual. Se trabajó con 50 cepas de las especies: Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum canis, Nannizzia gypsea, Trichophyton tonsurans y Epidermophyton floccosum. Los antifúngicos probados fueron terbinafina, itraconazol y fluconazol. Para el estudio de la sensibilidad se desarrolló la técnica de microdilución en caldo según el documento M38-3ra ed. del Clinical and Laboratory Standards Institute. El inóculo fue ajustado a 103 UFC/ml. Se incubaron a 35° C con lecturas diarias hasta las 96 horas. Terbinafina fue la de mayor actividad antifungica (CIM entre 0,03 y 0,50 μg/ml), seguida por itraconazol (CIM entre 0,12 y 4 μg/ml). Fluconazol mostró la menor actividad antifúngica (CIM de 8 a > 64 μg/ml). Se concluye que la terbinafina presenta la mayor actividad antifúngica in vitro frente a las cepas de dermatofitos estudiadas.

scholarly journals Antifungal Agents: Design, Synthesis, Antifungal Activity and Molecular Docking of Phloroglucinol Derivatives

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3116 ◽  
Author(s):  
Xingxing Teng ◽  
Yuanyuan Wang ◽  
Jinhua Gu ◽  
Peiqi Shi ◽  
Zhibin Shen ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Antifungal Activity ◽  
Protein Binding ◽  
Binding Site ◽  
Antifungal Agents ◽  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Protein Binding Site ◽  
Antifungal Activities ◽  
Phloroglucinol Derivatives

Pseudoaspidinol is a phloroglucinol derivative with Antifungal activity and is a major active component of Dryopteris fragrans. In our previous work, we studied the total synthesis of pseudoaspidinol belonging to a phloroglucinol derivative and investigated its antifungal activity as well as its intermediates. However, the results showed these compounds have low antifungal activity. In this study, in order to increase antifungal activities of phloroglucinol derivatives, we introduced antifungal pharmacophore allylamine into the methylphloroglucinol. Meanwhile, we remained C1–C4 acyl group in C-6 position of methylphloroglucinol using pseudoaspidinol as the lead compound to obtain novel phloroglucinol derivatives, synthesized 17 compounds, and evaluated antifungal activities on Trichophyton rubrum and Trichophyton mentagrophytes in vitro. Molecular docking verified their ability to combine the protein binding site. The results indicated that most of the compounds had strong antifungal activity, in which compound 17 were found to be the most active on Trichophyton rubrum with Minimum Inhibitory Concentration (MIC) of 3.05 μg/mL and of Trichophyton mentagrophytes with MIC of 5.13 μg/mL. Docking results showed that compounds had a nice combination with the protein binding site. These researches could lay the foundation for developing antifungal agents of clinical value.

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