scholarly journals Antifungal activity and mechanism of heat-transformed ginsenosides from notoginseng against Epidermophyton floccosum, Trichophyton rubrum, and Trichophyton mentagrophytes

RSC Advances ◽  
2017 ◽  
Vol 7 (18) ◽  
pp. 10939-10946 ◽  
Author(s):  
Peng Xue ◽  
Xiushi Yang ◽  
Xiaoyan Sun ◽  
Guixing Ren
Keyword(s):  
Antifungal Activity ◽  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Epidermophyton Floccosum ◽  
Heat Transformation

The improved antifungal activity of notoginseng can be attributed to the formation of less polar ginsenosides by heat transformation.

scholarly journals Antifungal Activity of Eugenia umbelliflora against Dermatophytes

2009 ◽  
Vol 4 (9) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Karina E. Machado ◽  
Valdir Cechinel Filho ◽  
Rosana C. B. Cruz ◽  
Christiane Meyre-Silva ◽  
Alexandre Bella Cruz
Keyword(s):  
Antifungal Activity ◽  
Betulinic Acid ◽  
Fungal Pathogens ◽  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Microsporum Canis ◽  
Microsporum Gypseum ◽  
Epidermophyton Floccosum ◽  
Agar Dilution

Antifungal activities of Eugenia umbelliflora Berg. (Myrtaceae) were tested in vitro against a panel of standard and clinical isolates of human fungal pathogens (dermatophytes and opportunistic saprobes). Methanol extracts of leaves and fruits of E. umbelliflora were separately prepared and partitioned, to yield dichloromethane (DCM), ethyl acetate (EtOAc) and aqueous fractions (Aq). Three compounds (1-3) were obtained from the DCM extract using chromatographic procedures. Antifungal assays were performed using agar dilution techniques. Both extracts (fruits and leaves), their DCM and EtOAc fractions, and compound 2 (betulin and betulinic acid) presented selective antifungal activity against dermatophytes (Epidermophyton floccosum, Microsporum canis, Microsporum gypseum, Trichophyton rubrum, Trichophyton mentagrophytes), with MIC values between 200 and 1000 μg/mL, and interestingly, inhibited 4/5 species with MIC values of ≤500 ≤g/mL. The aqueous fractions of fruits and leaves, and compounds 1 (α, β amyrin) and 3 (taraxerol) were inactive up to the maximum concentrations tested (1000 μg/mL).

scholarly journals Antifungal Agents: Design, Synthesis, Antifungal Activity and Molecular Docking of Phloroglucinol Derivatives

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3116 ◽  
Author(s):  
Xingxing Teng ◽  
Yuanyuan Wang ◽  
Jinhua Gu ◽  
Peiqi Shi ◽  
Zhibin Shen ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Antifungal Activity ◽  
Protein Binding ◽  
Binding Site ◽  
Antifungal Agents ◽  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Protein Binding Site ◽  
Antifungal Activities ◽  
Phloroglucinol Derivatives

Pseudoaspidinol is a phloroglucinol derivative with Antifungal activity and is a major active component of Dryopteris fragrans. In our previous work, we studied the total synthesis of pseudoaspidinol belonging to a phloroglucinol derivative and investigated its antifungal activity as well as its intermediates. However, the results showed these compounds have low antifungal activity. In this study, in order to increase antifungal activities of phloroglucinol derivatives, we introduced antifungal pharmacophore allylamine into the methylphloroglucinol. Meanwhile, we remained C1–C4 acyl group in C-6 position of methylphloroglucinol using pseudoaspidinol as the lead compound to obtain novel phloroglucinol derivatives, synthesized 17 compounds, and evaluated antifungal activities on Trichophyton rubrum and Trichophyton mentagrophytes in vitro. Molecular docking verified their ability to combine the protein binding site. The results indicated that most of the compounds had strong antifungal activity, in which compound 17 were found to be the most active on Trichophyton rubrum with Minimum Inhibitory Concentration (MIC) of 3.05 μg/mL and of Trichophyton mentagrophytes with MIC of 5.13 μg/mL. Docking results showed that compounds had a nice combination with the protein binding site. These researches could lay the foundation for developing antifungal agents of clinical value.

scholarly journals Frecuencia de dermatomicosis y factores asociados en población vulnerable de la ciudad de Manizales. Colombia. 2011

2016 ◽  
Vol 18 (6) ◽  
pp. 953
Author(s):  
Gloria Ines Estrada Salazar ◽  
José A. Chacón-Cardona
Keyword(s):  
Candida Albicans ◽  
Trichophyton Rubrum ◽  
Culture Media ◽  
Trichophyton Mentagrophytes ◽  
Direct Analysis ◽  
Microsporum Gypseum ◽  
Epidermophyton Floccosum ◽  
Palabras Clave ◽  
Fusarium Sp ◽  
Cutaneous Mycosis

Resumen:Objetivo: Determinar la frecuencia de las dermatomicosis en personas de diferentes instituciones de atención social en la ciudad de Manizales durante el año 2011. Método: Mediante la toma de muestras de los sitios que presentaban algún tipo de lesión sospechosa de ser una micosis cutánea, se hizo un análisis directo con KOH y cultivo en medios de Saboureaud y Mycosel. Se aplicó un instrumento de recolección de información para establecer  factores asociados con la presencia de estos microorganismos.Resultados: Los hongos levaduriformes encontrados con mayor frecuencia fueron: Candida albicans, Trichosporon sp, y los mohos saprofitos Penicillium sp, fusarium sp; seguido de hongos dermatofitos como: Trichophyton mentagrophites, Trichophyton rubrum, Epidermophyton floccosum y Microsporum gypseum. Las lesiones secas y descamativas se encontraron con mayor frecuencia. El compartir baños y vivir en hacinamiento y el uso de elementos comunes fueron los factores asociados más importantes en este estudio.Conclusiones. Las dermatomicosis son frecuentes en poblaciones vulnerables y se asocian a diferentes factores muy similares a los encontrados en otros estudios de igual naturaleza.    Palabras clave: dermatomicosis, onicomicosis, jóvenes, ancianos, factores asociados. Summary:Objective: To determine the frequency of ringworm in people of different social care institutions in the city of Manizales in 2011.Method: Using the sampling sites that had some kind of suspicious lesion from a cutaneous mycosis, direct analysis with KOH and culture media was Saboureaud and Mycosel. An instrument of data collection was used to establish factors associated with the presence of these microorganisms.Results: The yeast found most frequently were: Candida albicans, Trichosporon sp and Penicillium molds saprophytes sp, Fusarium sp, followed by dermatophyte fungi such as Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum and Microsporum gypseum. Dry scaly lesions were found more frequently. The shared bathrooms and living in overcrowded and the use of common elements were the most important in this study associated factors.Conclusions: Dermatomycoses are common in vulnerable populations and are associated with different very similar to those found in other studies of the same nature factors. Keywords: ringworm, onychomycosis, young, old, associated factors.

scholarly journals In vitro evaluation of the antifungal activity of Marco (Ambrosia arborescens Mill.) and Matico (Aristeguietia glutinosa Lam.) on the pathogenic fungi that cause dermatomycosis (ringworm)

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 559
Author(s):  
Tatiana de los Ángeles Mosquera Tayupanta ◽  
Sandra Elizabeth Ayala Valarezo ◽  
Tatiana Alexandra Vasquez Villareal ◽  
María Belén Montaluisa Álvarez
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Trichophyton Rubrum ◽  
Therapeutic Potential ◽  
Pathogenic Fungi ◽  
Trichophyton Mentagrophytes ◽  
Microsporum Canis ◽  
The One ◽  
One Way Anova

Background: Currently, there is a trend towards using natural and ethnopharmacological species with therapeutic potential. This investigation evaluated the antifungal activity of two species in the Ecuadorian Andes, which are used in treating dermatomycosis: Ambrosia arborescens Mill. (Marco) and Aristeguietia glutinosa Lam. (Matico). Methods: We worked with seven concentrations (100 to 700ppm) of Ambrosia arborescens Mill. extract and ten concentrations (0.5 to 5%) of essential oil (EO) of Aristeguietia glutinosa Lam. on Trichophyton mentagrophytes ATCC 9533, Trichophyton rubrum ATCC 28188, Microsporum canis ATCC 36299 and Candida albicans ATCC 10231. The methodology used was a modified version of the Kirby-Bauer method, using diffusion in agar wells. Results: The Tukey test, after the one-way Anova, determined effective concentrations of EO: 5% for Trichophyton mentagrophytes, 4.5% for Trichophyton rubrum, 5% for Microsporum canis and 2% for Candida albicans. In the extracts, the concentration of 700ppm was used for Trichophyton mentagrophytes, Trichophyton rubrum, and 600ppm for Microsporum canis and Candida albicans. Conclusions: The evaluation of the antifungal activity of the Ambrosia arborescens extract showed inhibition in the studied dermatophytes in each one of the planted concentrations (100 to 700ppm). The evaluation of the antifungal activity of Aristeguietia glutinosa EO showed inhibition in the studied dermatophytes in each of the planted concentrations (0.5 to 5%).

scholarly journals Antifungal Activity of Pericopsis (Afrormosia) laxiflora (Benth.) Bark on Ringworm Germs

2020 ◽  
pp. 1-9
Author(s):  
Ouattara Abou ◽  
Bolou Gbouhoury Eric-Kévin ◽  
Koffi Allali Eugène ◽  
Yasseu Hyacinthe ◽  
Ouattara Karamoko ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Cote D'ivoire ◽  
Inhibitory Concentration ◽  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Fungal Strain ◽  
Phytochemical Study ◽  
High Frequencies ◽  
The Subject ◽  
Hydroethanolic Extract

Dermatophytes are responsible for ringworms that are very often found on the heads of children in Africa. In Côte d'Ivoire, ringworms have been the subject of several studies revealing fairly high frequencies. Aims: The present work consisted essentially in studying the antifungal activity of the barks of Pericopsis laxiflora, a plant from the Ivorian pharmacopoeia on germs responsible for ringworm. Methodology: The 70% hydroethanolic extract of the bark of Pericopsis laxiflora was prepared and tested on Trichophyton mentagrophytes and Trichophyton rubrum. In addition, by staining and precipitation tests, phytochemical sorting was carried out on this extract. Results: Faced with the hydroethanolic extract, Trichophyton mentagrophytes recorded a Minimun Inhibitory Concentration (MIC) which is equal to the Minimun Fungicidal Concentration(MFC) (MIC = MFC = 6.25 mg/mL). For the fungal strain of T. rubrum, the MFC obtained (100 mg/mL) was twice the MIC (50 mg/mL). The phytochemical study of this extract revealed the presence of sterols and polyterpenes, flavonoids and catechic tannins. Conclusion: The results suggest that P. laxiflora extract could therefore be useful in the fight against dermatophytes.

scholarly journals Antifungal Activity of Maytenin and Pristimerin

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Fernanda P. Gullo ◽  
Janaina C. O. Sardi ◽  
Vânia A. F. F. M. Santos ◽  
Fernanda Sangalli-Leite ◽  
Nayla S. Pitangui ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Antifungal Agents ◽  
Trichophyton Rubrum ◽  
Fungal Infections ◽  
Human Keratinocytes ◽  
Trichophyton Mentagrophytes ◽  
Pharmacological Activities ◽  
Etiologic Agents ◽  
High Incidence ◽  
Maytenus Ilicifolia

Fungal infections in humans have increased alarmingly in recent years, particularly in immunocompromised individuals. Among the infections systemic candidiasis, aspergillosis, cryptococcosis, paracoccidioidomycosis, and histoplasmosis mortality are more prevalent and more severe in humans. The current high incidence of dermatophytosis is in humans, especially as the main etiologic agentsTrichophyton rubrumandTrichophyton mentagrophytes. Molecules pristimerin and maytenin obtained from the plantMaytenus ilicifolia(Celastraceae) are known to show various pharmacological activities. This study aimed to evaluate the spectrum of antifungal activity of maytenin and pristimerin and their cytotoxicity in human keratinocytes (NOK cells of the oral mucosa). It was concluded that the best spectrum of antifungal activity has been shown to maytenin with MIC varying from 0.12 to 125 mg/L, although it is also active with pristimerin MIC ranging between 0.12 and 250 mg/L. Regarding the toxicity, both showed to have high IC50. The SI showed high pristimerin against some species of fungi, but SI maytenin was above 1.0 for all fungi tested, showing a selective action of fungi. However, when comparing the two substances, maytenin also showed better results. The two molecules can be a possible prototype with a broad spectrum of action for the development of new antifungal agents.

Pattern of dermatophyte in Bangabandhu Sheikh Mujib Medical University

2012 ◽  
Vol 6 (2) ◽  
pp. 11-14 ◽  
Author(s):  
Mst. Rummana Rahim ◽  
Ahmed Abu Saleh ◽  
Md. Ruhul Amin Miah ◽  
Shaheda Anwar ◽  
Md. Muzibur Rahman
Keyword(s):  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Age Group ◽  
Female Ratio ◽  
Epidermophyton Floccosum ◽  
Tinea Unguium ◽  
Medical University ◽  
Male To Female ◽  
Dermatophyte Species ◽  
Culture Positive

Dermatophytes are by far the most significant fungi because of their widespread involvement of population at large and their prevalence all over the world. This is an attempt to observe the spectrum of dermatophytes among the clinically suspected cases of dermatophytosis attending the outpatient department of Dermatology and Venereology, Bangabandhu Sheik Mujib Medical University, Dhaka. Three hundred and twenty clinically suspected cases of dermatophytosis were subjected to mycological studies. One hundred and five cases (32.8%) were positive for fungus in direct microscopy while 97(30.3%) were culture positive. Tinea unguium was the most common clinical type encountered followed by tinea corporis. Dermatophytosis was more common in the age group of 21-30 years. The male to female ratio was 1.54:1. Trichophyton rubrum 84(86.6%) was found common etiological dermatophyte species followed by Trichophyton mentagrophytes 8(8.2%) and Epidermophyton floccosum 5(5.2%).DOI: http://dx.doi.org/10.3329/bjmm.v6i2.19370 Bangladesh J Med Microbiol 2012; 06(02): 11-14

scholarly journals Sertaconazole Nitrate Shows Fungicidal and Fungistatic Activities against Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, Causative Agents of Tinea Pedis

2011 ◽  
Vol 55 (9) ◽  
pp. 4420-4421 ◽  
Author(s):  
Alfonso J. Carrillo-Muñoz ◽  
Cristina Tur-Tur ◽  
Delia C. Cárdenes ◽  
Dolors Estivill ◽  
Gustavo Giusiano
Keyword(s):  
Tinea Pedis ◽  
Fungicidal Activity ◽  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Clinical Isolates ◽  
Geometric Means ◽  
Epidermophyton Floccosum ◽  
Content Type ◽  
Causative Agents

ABSTRACTThe fungistatic and fungicidal activities of sertaconazole against dermatophytes were evaluated by testing 150 clinical isolates of causative agents of tinea pedis,Trichophyton rubrum,Trichophyton mentagrophytes, andEpidermophyton floccosum. The overall geometric means for fungistatic and fungicidal activities of sertaconazole against these isolates were 0.26 and 2.26 μg/ml, respectively, although values were higher forT. mentagrophytesthan for the others. This is the first comprehensive demonstration of the fungicidal activity of sertaconazole against dermatophytes.

Sign in / Sign up

Export Citation Format

Share Document