Stromal cell-derived factor-1 (SDF-1/CXCL12) gene polymorphisms in pulmonary tuberculosis patients of south India

2011 ◽  
Vol 39 (1) ◽  
pp. 26-31 ◽  
Author(s):  
P. Selvaraj ◽  
K. Alagarasu ◽  
B. Singh
Keyword(s):  
Pulmonary Tuberculosis ◽  
Gene Polymorphisms ◽  
Stromal Cell ◽  
South India ◽  
Tuberculosis Patients ◽  
Stromal Cell Derived Factor

Toll-like receptor and TIRAP gene polymorphisms in pulmonary tuberculosis patients of South India

Tuberculosis ◽  
2010 ◽  
Vol 90 (5) ◽  
pp. 306-310 ◽  
Author(s):  
P. Selvaraj ◽  
M. Harishankar ◽  
Brijendra Singh ◽  
M.S. Jawahar ◽  
V.V. Banurekha
Keyword(s):  
Pulmonary Tuberculosis ◽  
Gene Polymorphisms ◽  
South India ◽  
Toll Like Receptor ◽  
Tuberculosis Patients

scholarly journals Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Eliana Peresi ◽  
Larissa Ragozo Cardoso Oliveira ◽  
Weber Laurentino da Silva ◽  
Érika Alessandra Pellison Nunes da Costa ◽  
João Pessoa Araujo ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Plasma Levels ◽  
Gene Polymorphisms ◽  
Essential Role ◽  
Active Tuberculosis ◽  
Mrna Levels ◽  
Tuberculosis Patients ◽  
Antituberculosis Treatment ◽  
Cytokine Levels ◽  
Tuberculosis Disease

Cytokines play an essential role during active tuberculosis disease and cytokine genes have been described in association with altered cytokine levels. Therefore, the aim of this study was to verify ifIFNG, IL12B, TNF, IL17A, IL10, and TGFB1gene polymorphisms influence the immune response of Brazilian patients with pulmonary tuberculosis (PTB) at different time points of antituberculosis treatment (T1, T2, and T3). Our results showed the following associations:IFNG+874 T allele andIFNG+2109 A allele with higher IFN-γlevels;IL12B+1188 C allele with higher IL-12 levels;TNF−308 A allele with higher TNF-αplasma levels in controls and mRNA levels in PTB patients at T1;IL17AA allele at rs7747909 with higher IL-17 levels;IL10−819 T allele with higher IL-10 levels; andTGFB1+29 CC genotype higher TGF-βplasma levels in PTB patients at T2. The present study suggests thatIFNG+874T/A,IFNG+2109A/G,IL12B+1188A/C,IL10−819C/T, andTGFB1+21C/T are associated with differential cytokine levels in pulmonary tuberculosis patients and may play a role in the initiation and maintenance of acquired cellular immunity to tuberculosis and in the outcome of the active disease while on antituberculosis treatment.

Sputum collection and disposal among pulmonary tuberculosis patients in coastal South India [Short communication]

2013 ◽  
Vol 17 (5) ◽  
pp. 621-623
Author(s):  
T. Rekha ◽  
P. Singh ◽  
B. Unnikrishnan ◽  
P. Prasanna Mithra ◽  
N. Kumar ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
South India ◽  
Short Communication ◽  
Tuberculosis Patients

G801A Polymorphism of Human Stromal Cell–Derived Factor 1 Gene Raises No Susceptibility to Neoplastic Lesions of Uterine Cervix

2012 ◽  
Vol 22 (8) ◽  
pp. 1297-1302 ◽  
Author(s):  
Yi-Torng Tee ◽  
Shun-Fa Yang ◽  
Po-Hui Wang ◽  
Hsiu-Ting Tsai ◽  
Long-Yau Lin ◽  
...  
Keyword(s):  
Uterine Cervix ◽  
Gene Polymorphisms ◽  
Stromal Cell ◽  
Cervical Neoplasia ◽  
Low Grade ◽  
Significant Difference ◽  
Neoplastic Lesions ◽  
Polymerase Chain ◽  
Stromal Cell Derived Factor ◽  
Increased Susceptibility

ObjectiveThis study aimed to investigate the association of stromal cell–derived factor 1 (SDF-1) gene polymorphisms with the neoplastic lesions of uterine cervix in Mid-Taiwan women.Materials and MethodsFour hundred ninety-eight blood samples were collected from 161 patients with neoplasia of uterine cervix, including 76 cancer patients, 61 patients with high-grade dysplasia, and 24 with low-grade dysplasia, and 337 healthy controls who lived in Mid-Taiwan. Polymorphism of the SDF-1 gene was examined using polymerase chain reaction–restriction fragment length polymorphism.ResultsFor SDF-1 gene polymorphisms, the wild-type homozygous alleles (G/G) yielded 100- and 193-bp products, the heterozygous alleles (G/A) yielded 100-, 193- and 293-bp products, whereas the mutated-type homozygous alleles (A/A) yielded a 293-bp product. We found no significant difference in genotypes or alleles distribution of SDF-1 polymorphisms between patients with cervical neoplasia and healthy women (P = 0.530). Compared with the homozygous GG subgroup, GA and AA subgroups do not increase the risk of cervical neoplasia.ConclusionsAlthough the expression of SDF-1 was reported to be significantly increased in cervical carcinogenesis in previous studies, our results, however, show that SDF-1 gene polymorphism could not be considered as a factor related to an increased susceptibility to cervical neoplasia.

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