scholarly journals Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Eliana Peresi ◽  
Larissa Ragozo Cardoso Oliveira ◽  
Weber Laurentino da Silva ◽  
Érika Alessandra Pellison Nunes da Costa ◽  
João Pessoa Araujo ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Plasma Levels ◽  
Gene Polymorphisms ◽  
Essential Role ◽  
Active Tuberculosis ◽  
Mrna Levels ◽  
Tuberculosis Patients ◽  
Antituberculosis Treatment ◽  
Cytokine Levels ◽  
Tuberculosis Disease

Cytokines play an essential role during active tuberculosis disease and cytokine genes have been described in association with altered cytokine levels. Therefore, the aim of this study was to verify ifIFNG, IL12B, TNF, IL17A, IL10, and TGFB1gene polymorphisms influence the immune response of Brazilian patients with pulmonary tuberculosis (PTB) at different time points of antituberculosis treatment (T1, T2, and T3). Our results showed the following associations:IFNG+874 T allele andIFNG+2109 A allele with higher IFN-γlevels;IL12B+1188 C allele with higher IL-12 levels;TNF−308 A allele with higher TNF-αplasma levels in controls and mRNA levels in PTB patients at T1;IL17AA allele at rs7747909 with higher IL-17 levels;IL10−819 T allele with higher IL-10 levels; andTGFB1+29 CC genotype higher TGF-βplasma levels in PTB patients at T2. The present study suggests thatIFNG+874T/A,IFNG+2109A/G,IL12B+1188A/C,IL10−819C/T, andTGFB1+21C/T are associated with differential cytokine levels in pulmonary tuberculosis patients and may play a role in the initiation and maintenance of acquired cellular immunity to tuberculosis and in the outcome of the active disease while on antituberculosis treatment.

scholarly journals Serum Procalcitonin Levels Predict Mortality Risk in Patients With Pulmonary Tuberculosis: A Single-Center Prospective Observational Study

2020 ◽  
Vol 222 (10) ◽  
pp. 1651-1654
Author(s):  
Takeshi Osawa ◽  
Masato Watanabe ◽  
Kozo Morimoto ◽  
Masao Okumura ◽  
Takashi Yoshiyama ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Mortality Risk ◽  
Prospective Observational Study ◽  
Bacterial Load ◽  
Serum Levels ◽  
Risk Indicator ◽  
Radiographic Findings ◽  
Tuberculosis Patients ◽  
Antituberculosis Treatment ◽  
Immunodeficiency Virus

Abstract Globally, tuberculosis is the leading infectious cause of death; discovering biomarkers that predict a high mortality risk may improve treatment outcomes. We prospectively enrolled 252 pulmonary tuberculosis patients who were not coinfected with human immunodeficiency virus and initiated antituberculosis treatment, measured serum procalcitonin levels (PCT), and assessed mortality risk. PCT serum levels higher than 0.13 (day 0), 0.05 (day 7), 0.12 (day 14), or 0.06 (day 28) ng/mL predicted nonsurvivors with odds ratios of 7.9, 14.3, 20.0, and 7.3, respectively (P ≤ .005 for all), respectively. Therefore, serum PCT levels are a promising mortality risk indicator for patients with pulmonary tuberculosis. Main Point. For patients with pulmonary tuberculosis, a promising mortality risk indicator is the level of serum procalcitonin, which is weakly associated with sputum bacterial load and independent of radiographic findings.

scholarly journals Heightened Systemic Levels of Neutrophil and Eosinophil Granular Proteins in Pulmonary Tuberculosis and Reversal following Treatment

2018 ◽  
Vol 86 (6) ◽  
Author(s):  
Kadar Moideen ◽  
Nathella Pavan Kumar ◽  
Dina Nair ◽  
Vaithilingam V. Banurekha ◽  
Ramalingam Bethunaickan ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Plasma Levels ◽  
Eosinophil Cationic Protein ◽  
Proteinase 3 ◽  
Cationic Protein ◽  
Indirect Measure ◽  
Content Type ◽  
Immune Effector ◽  
Effector Cells ◽  
Antituberculosis Treatment

ABSTRACT Granulocytes are activated during Mycobacterium tuberculosis infection and act as immune effector cells, and granulocyte responses are implicated in tuberculosis (TB) pathogenesis. Plasma levels of neutrophil and eosinophil granular proteins provide an indirect measure of degranulation. In this study, we wanted to examine the levels of neutrophil and eosinophil granular proteins in individuals with pulmonary tuberculosis (PTB) and to compare them with the levels in individuals with latent TB (LTB). Hence, we measured the plasma levels of myeloperoxidase (MPO), neutrophil elastase, proteinase 3, major basic protein (MBP), eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP), and eosinophil peroxidase (EPX) in these individuals. Finally, we also measured the levels of all of these proteins in PTB individuals following antituberculosis treatment (ATT). Our data reveal that PTB individuals are characterized by significantly higher plasma levels of MPO, elastase, proteinase 3, as well as MBP and EDN in comparison to those in LTB individuals. Our data also reveal that ATT resulted in the reversal of all of these changes, indicating an association with TB disease. Finally, our data show that the systemic levels of MPO and proteinase 3 can significantly discriminate PTB from LTB individuals. Thus, our data suggest that neutrophil and eosinophil granular proteins could play a potential role in the innate immune response and, therefore, the pathogenesis of pulmonary TB.

scholarly journals Inflammatory and immunogenetic markers in correlation with pulmonary tuberculosis

2013 ◽  
Vol 39 (6) ◽  
pp. 719-727 ◽  
Author(s):  
Beatriz Lima Alezio Muller ◽  
Daniela Maria de Paula Ramalho ◽  
Paula Fernanda Gonçalves dos Santos ◽  
Eliene Denites Duarte Mesquita ◽  
Afranio Lineu Kritski ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Pulmonary Tuberculosis ◽  
Gene Polymorphisms ◽  
Serum Levels ◽  
Acute Inflammatory Response ◽  
Reactive Protein ◽  
Antituberculosis Treatment ◽  
Tnf Α ◽  
Referral Hospitals ◽  
Ifn Γ

OBJECTIVE: To describe serum levels of the cytokines IL-10, TNF-α, and IFN-γ, as well as polymorphisms in the genes involved in their transcription, and their association with markers of the acute inflammatory response in patients with pulmonary tuberculosis.METHODS: This was a descriptive, longitudinal study involving 81 patients with pulmonary tuberculosis treated at two referral hospitals. We collected data on sociodemographic variables and evaluated bacteriological conversion at the eighth week of antituberculosis treatment, gene polymorphisms related to the cytokines studied, and serum levels of those cytokines, as well as those of C-reactive protein (CRP). We also determined the ESR and CD4+ counts.RESULTS: The median age of the patients was 43 years; 67 patients (82.7%) were male; and 8 patients (9.9%) were infected with HIV. The ESR was highest in the patients with high IFN-γ levels and low IL-10 levels. IFN-γ and TNF-α gene polymorphisms at positions +874 and −238, respectively, showed no correlations with the corresponding cytokine serum levels. Low IL-10 levels were associated with IL-10 gene polymorphisms at positions −592 and −819 (but not −1082). There was a negative association between bacteriological conversion at the eighth week of treatment and CRP levels.CONCLUSIONS: Our results suggest that genetic markers and markers of acute inflammatory response are useful in predicting the response to antituberculosis treatment.

Cytokine gene polymorphisms and cytokine levels in pulmonary tuberculosis

Cytokine ◽  
2008 ◽  
Vol 43 (1) ◽  
pp. 26-33 ◽  
Author(s):  
P. Selvaraj ◽  
K. Alagarasu ◽  
M. Harishankar ◽  
M. Vidyarani ◽  
D. Nisha Rajeswari ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Gene Polymorphisms ◽  
Cytokine Gene ◽  
Cytokine Levels ◽  
Cytokine Gene Polymorphisms

scholarly journals Routine laboratory parameters of newly diagnosed pulmonary tuberculosis patients: a single center study in Brazil

2020 ◽  
Vol 9 (11) ◽  
pp. e2559119873
Author(s):  
Ana Paula Biadola ◽  
André Aparecido dos Santos Correa ◽  
Amanda Aparecida Silva de Aguiar ◽  
Ualter Guilherme Cipriano Rosa ◽  
Paulo José Mascarenhas Mazaro ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Medical Records ◽  
Leukocyte Count ◽  
Hematological Parameters ◽  
Total Leukocyte Count ◽  
Clinical Prognosis ◽  
Tuberculosis Patients ◽  
Antituberculosis Treatment ◽  
Single Center Study ◽  
Using Data

Objective: Evaluate the severity of tuberculosis and its association with laboratory tests before antituberculosis treatment. Methodology: Patients with pulmonary tuberculosis were evaluated for severity using data available in medical records (Clinical; Excretion of mycobacteria; and Diagnostic imaging) and associated with biochemical and hematological parameters requested at the time of diagnosis and before antituberculosis treatment. Results: The evaluation of the severity showed a predominance of smear AFB (+), fever associated with other symptoms and infiltrative tuberculosis. Only a positive correlation between mycobacteria excretion and imaging diagnosis (rho=0.47; p=0.023) was observed. The patients presented hyponatremia (9/21), hypomagnesemia (6/13), and hypercalcemia (1/13), unrelated to the severity. The presence of fever influenced the number of non-segmented neutrophils (p=0.0142) and the total leukocyte count correlated with the increase in total neutrophils (rho=0.9631; p<0.0001). Conclusion: Different severity characteristics of tuberculosis, although they reflect the degree of commitment of the patient, are not always correlated; the evaluation of electrolytes could contribute to clinical behavior; and non-segmented neutrophils are associated with a worse clinical prognosis in patients with tuberculosis.

scholarly journals The Effect of Telehomecare application to the knowledge of patient with pulmonary tuberculosis about Tuberculosis disease transmission

2017 ◽  
Vol 4 (3) ◽  
pp. 206-210
Author(s):  
Ning Arti Wulandari
Keyword(s):  
Pulmonary Tuberculosis ◽  
Nursing Care ◽  
Disease Transmission ◽  
Care Service ◽  
Rank Test ◽  
Transmission Method ◽  
Tuberculosis Patients ◽  
Use Of Technology ◽  
Before And After ◽  
Tuberculosis Disease

Tuberculosis (TB) disease is transmitted through a "droplet infection". Currently it is still very difficult to cut the chain chain of transmission of tuberculosis disease, this is due to lack of knowledge of patients about the prevention of transmission of tuberculosis. Forms of health services to patients with tuberculosis currently focuses on treatment. Education is actually also given but still less than the maximum due to limited time to have a health officer reach too broad. Therefore the use of technology in providing nursing care to tuberculosis patients at home. The technique used is telehomecare, where officers will provide education and followup to tuberculosis patients through cellular telepone. The purpose of this study was to identify the effect of telehomecare application on the knowledge of pulmonary tuberculosis patients about Tuberculosis disease transmission. Method: The design of this study was one group pretest posttest design, conducted from 18 April to 30 June 2012 with a sample of 14 pulmonary tuberculosis patients in the work area of Puskesmas Kanigoro Blitar district taken from the entire population. The data obtained will be analyzed with Wilcoxon Signed Rank test. The results of this study there are differences in knowledge before and after being given education via telehomecare with a value of P = 0.02. Discussion: Telehomecare program can be applied in Puskesmas, clinic or hospital to improve nursing care service

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