Circulating Levels of Stromal Cell-Derived Factor 1α and Interleukin 7 in HIV Type 1 Infection and Pulmonary Tuberculosis Are Reciprocally Related to CXCR4 Expression on Peripheral Blood Leukocytes

2003 ◽  
Vol 19 (6) ◽  
pp. 461-468 ◽  
Author(s):  
Sharon Shalekoff ◽  
Caroline T. Tiemessen
Keyword(s):  
Pulmonary Tuberculosis ◽  
Stromal Cell ◽  
Cxcr4 Expression ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes ◽  
Interleukin 7 ◽  
Hiv Type 1 ◽  
Stromal Cell Derived Factor ◽  
Circulating Levels

Elevated Plasma Stromal Cell-Derived Factor 1 Protein Level in the Progression of HIV Type 1 Infection/AIDS

2001 ◽  
Vol 17 (7) ◽  
pp. 587-595 ◽  
Author(s):  
Masaya Ikegawa ◽  
Jingli Yuan ◽  
Kazuko Matsumoto ◽  
Steve Herrmann ◽  
Aikichi Iwamoto ◽  
...  
Keyword(s):  
Protein Level ◽  
Stromal Cell ◽  
Elevated Plasma ◽  
Hiv Type 1 ◽  
Stromal Cell Derived Factor

scholarly journals Stromal Cell–Derived Factor–1 Genotype, Coreceptor Tropism, and HIV Type 1 Disease Progression

2005 ◽  
Vol 192 (9) ◽  
pp. 1597-1605 ◽  
Author(s):  
Eric S. Daar ◽  
Henry S. Lynn ◽  
Sharyne M. Donfield ◽  
Alice Lail ◽  
Stephen J. O’Brien ◽  
...  
Keyword(s):  
Disease Progression ◽  
Stromal Cell ◽  
Coreceptor Tropism ◽  
Hiv Type 1 ◽  
Stromal Cell Derived Factor

scholarly journals Age-Related Changes in Expression of CXCR4 and CCR5 on Peripheral Blood Leukocytes from Uninfected Infants Born to Human Immunodeficiency Virus Type 1-Infected Mothers

2004 ◽  
Vol 11 (1) ◽  
pp. 229-234 ◽  
Author(s):  
Sharon Shalekoff ◽  
Glenda E. Gray ◽  
Caroline T. Tiemessen
Keyword(s):  
Human Immunodeficiency Virus ◽  
Cord Blood ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes ◽  
Cross Sectional ◽  
Age Related ◽  
Immunodeficiency Virus ◽  
Sectional Analysis ◽  
Exposed Uninfected

ABSTRACT Cross-sectional analysis of human immunodeficiency virus-exposed, uninfected infants revealed high proportions of CXCR4-expressing cells in their cord blood, which declined at 4.5 months and increased between 9 and 15 months to levels approaching those of uninfected adults. Proportions of CCR5-expressing cells, however, were very low in cord blood and subsequently increased with age.

scholarly journals Mobilization of long-term reconstituting hematopoietic stem cells in mice by recombinant human interleukin 7.

1995 ◽  
Vol 181 (1) ◽  
pp. 369-374 ◽  
Author(s):  
K J Grzegorzewski ◽  
K L Komschlies ◽  
S E Jacobsen ◽  
F W Ruscetti ◽  
J R Keller ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Peripheral Blood ◽  
Peripheral Blood Leukocytes ◽  
Gene Modification ◽  
Blood Leukocytes ◽  
Hematopoietic Stem ◽  
Interleukin 7 ◽  
Cell Repopulation

Administration of recombinant human interleukin 7 (rh)IL-7 to mice has been reported by our group to increase the exportation of myeloid progenitors (colony-forming unit [CFU]-c and CFU-granulocyte erythroid megakarocyte macrophage) from the bone marrow to peripheral organs (blood, spleen[s], and liver). We now report that IL-7 also stimulates a sixfold increase in the number of more primitive CFU-S day 8 (CFU-S8) and day 12 (CFU-S12) in the peripheral blood leukocytes (PBL) of mice treated with rhIL-7 for 7 d. Moreover, > 90% of lethally irradiated recipient mice that received PBL from rhIL-7-treated donor mice have survived for > 6 mo whereas none of the recipient mice that received an equal number of PBL from diluent-treated donors survived. Flow cytometry analysis at 3 and 6 mo after transplantation revealed complete trilineage (T, B, and myelomonocytic cell) repopulation of bone marrow, thymus, and spleen by blood-borne stem/progenitor cells obtained from rhIL-7-treated donor mice. Thus, IL-7 may prove valuable for mobilizing pluripotent stem cells with long-term repopulating activity from the bone marrow to the peripheral blood for the purpose of gene modification and/or autologous or allogeneic stem cell transplantation.

Interleukin-7 Induces HIV Type 1 Outgrowth From Peripheral Resting CD4+ T Cells

2004 ◽  
Vol 36 (5) ◽  
pp. 1103-1104 ◽  
Author(s):  
Ginger Lehrman ◽  
Loyda Ylisastigui ◽  
Ronald J. Bosch ◽  
David M. Margolis
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Interleukin 7 ◽  
Hiv Type 1
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