Activity of Cytochrome c Oxidase in the Right and Left Ventricular Myocardium of Male and Female Rats Exposed To Intermittent High Altitude Hypoxiaa

Background: In recent years, the use of middle-aged and old animals of both sexes has become preferential in experimental studies involving the models of cardiovascular diseases to better reflect a human population. However, the evidence showing the extent of sex-related differences in cardiac aging of laboratory animals remains obscure. Accordingly, we designed our study to determine whether the male and female rats differ during aging with regard to left ventricular (LV) geometry and systolic function. Methods: We performed transthoracic echocardiographic examinations in 12-month-old (12mo) and 24 month-old (24mo) male and female Sprague-Dawley rats (Charles River, Wilmington, MA) under 1.5% isoflurane anesthesia using a linear (Matrix) array transducer probe GE M12L (5.5-14.0 MHz) and a GE Vivid 7 Dimension ultrasound system. Two-dimensional short-axis views and M-mode tracings of the LV at the papillary muscle level were recorded and used to estimate various LV parameters. Results: We found that 24mo-Female rats had a significant increase in LV chamber dimensions associated with a reduction in its systolic performance as compared to 12mo-Female rats (Table 1). In contrast, LV parameters remained similar between 12mo- and 24mo-Male rats. Table 1. Echocardiographic parameters of LV chamber geometry and systolic performance Values are means ± SE. Arrow indicates a significant difference between age groups ( P ≤ 0.05). Conclusion: Our data demonstrate that during cardiac aging female rats have a different pattern of LV changes compared to males that must be considered in the design of future experimental studies.

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COMPARATIVE ICSH-ESTIMATIONS IN THE SERUM OF GONADECTOMIZED MALE AND FEMALE RATS WITH A TRANSPLANTED OVARY

Acta Endocrinologica ◽

10.1530/acta.0.0490239 ◽

1965 ◽

Vol 49 (2) ◽

pp. 239-247 ◽

Cited By ~ 2

Author(s):

T. Swelheim

Keyword(s):

Female Rats ◽

Ventral Prostate ◽

High Dose ◽

Corpora Lutea ◽

Male And Female ◽

Single High Dose ◽

Base Level ◽

Male And Female Rats ◽

The Difference ◽

The Right

ABSTRACT In adult female rats an ICSH-peak in the serum was found in the afternoon of pro-oestrus (preliminary experiments). ICSH was determined by the ventral prostate assay. Comparative ICSH-determinations were carried out in the serum of adult gonadectomized male and female rats with an ovarian transplant. Gonadectomy and transplantation of an ovary into the right hind-leg had been carried out two months previously. Irrespective as to whether there were corpora lutea in the transplants of castrated males, the ICSH-level in the serum of the males did not differ from the base level in the serum of the females. The ICSH-peak in the serum of the females (afternoon of pro-oestrus) exceeded this level. The relation between the ICSH-peak in the serum and ovulation was demonstrated by the fact that there was no ICSH-peak on the day of prooestrus in spayed females with an ovarian transplant, which in previous cycles had passed through a two days' oestrus. It is suggested that the difference in behaviour between ovarian transplants in spayed females and castrated males might be an expression of the same sex difference as that which appears in response to a single high dose of oestrogen.

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Possibly Late-Onset Arrhythmogenic Right Ventricular Cardiomyopathy: Unique Triglyceride Deposition by Analysis of Lipid Contents

Clinical Medicine Insights Case Reports ◽

10.1177/1179547619828715 ◽

2019 ◽

Vol 12 ◽

pp. 117954761982871

Author(s):

Kentaro Yamamoto ◽

Xin Guo ◽

Ken-ichi Mizutani ◽

Nozomu Kurose ◽

Motona Kumagai ◽

...

Keyword(s):

Right Ventricular ◽

Late Onset ◽

Arrhythmogenic Right Ventricular Cardiomyopathy ◽

Ventricular Myocardium ◽

Cholesterol Content ◽

Left Ventricular ◽

Left Ventricular Myocardium ◽

Ventricular Cardiomyopathy ◽

Lipid Contents ◽

The Right

We presented an unusual arrhythmogenic right ventricular cardiomyopathy (ARVC) case of a late-60s elderly man’s death, due to severe pericardial/pleural effusion and ascites, and arrhythmic events, with unique pathological features. The hypertrophic heart grossly displayed yellowish to yellow-whitish predominantly in the variably thinned wall of the dilated right ventricle. Microscopic findings showed diffuse fatty/fibrofatty replacement in not only the right but left ventricular myocardium, together with an outer lymphoplasmacytic infiltrate. According to the lipid contents analysis, the triglyceride content, but not the cholesterol content, in our patient’s right and left ventricular cardiac muscle was much higher than that in the control subject. We propose that this unique triglyceride deposition in our possibly late-onset ARVC case might be one of new clues to understand its enigmatic cause. Further prospective studies are needed to validate the presence and significance of a greater volume of triglyceride deposit, after collecting and investigating a larger number of early and late-onset ARVC cases examined.

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Noncompaction of the myocardium associated with Roifman syndrome

Cardiology in the Young ◽

10.1017/s1047951101000208 ◽

2001 ◽

Vol 11 (2) ◽

pp. 240-243 ◽

Cited By ~ 42

Author(s):

Karen Mandel ◽

Eyal Grunebaum ◽

Lee Benson

Keyword(s):

Interventricular Septum ◽

Retinal Dystrophy ◽

Ventricular Myocardium ◽

Left Ventricular ◽

Antibody Deficiency ◽

Left Ventricular Myocardium ◽

Facial Dysmorphism ◽

Ventricular Wall ◽

Immune Deficiencies ◽

The Right

Noncompaction of the ventricular myocardium, sometimes referred to as “spongy myocardium”, appears as excessive and prominent trabeculations and deep intratrabecular recesses within the ventricular wall, usually involving the left ventricle, although the right ventricle and interventricular septum can also be affected. It may occur with or without additional heart malformations. Roifman syndrome is a constellation of antibody deficiency, spondyloepiphyseal dysplasia, facial dysmorphism, growth retardation, and retinal dystrophy. We report a patient with Roifman syndrome who presented with noncompaction of the left ventricular myocardium. Our findings expand the spectrum of diseases associated with noncompaction. The recognition of noncompaction among patients with Roifman syndrome is important, as the immune deficiencies may be subtle and undiagnosed until adulthood. Thus, some patients may first present with cardiac failure.

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Absence of the left ventricular myocardium in a newborn

Cardiology in the Young ◽

10.1017/s1047951100004005 ◽

1996 ◽

Vol 6 (4) ◽

pp. 344-347 ◽

Cited By ~ 1

Author(s):

Angelika Lindinger ◽

Yvonne Masur ◽

Hans-Gerhard Limbach

Keyword(s):

Aortic Valve ◽

Left Ventricle ◽

Ventricular Myocardium ◽

Arrhythmogenic Right Ventricular Dysplasia ◽

Left Ventricular ◽

Adolescent And Young Adult ◽

Left Ventricular Myocardium ◽

Fatty Replacement ◽

Myocardial Fibers ◽

The Right

SummaryAbsence of myocardial fibers in the right ventricle is the essence of so-called Uhl's anomaly, which should be distinguished from the fatty replacement producing arrhythmogenic right ventricular dysplasia of the adolescent and young adult. In this report, we describe a newborn with nearly complete absence of the myocardium of the left ventricle. The infant died on the seventh day because of myocardial incompetence of the left ventricle, which was unable to open the aortic valve.

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