Enhancement of gene expression and melanin production of human tyrosinase gene loaded in elastic cationic niosomes

2012 ◽  
Vol 64 (10) ◽  
pp. 1376-1385 ◽  
Author(s):  
Narinthorn Khositsuntiwong ◽  
Aranya Manosroi ◽  
Friedrich Götz ◽  
Rolf G. Werner ◽  
Worapaka Manosroi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Melanin Production ◽  
Tyrosinase Gene ◽  
Cationic Niosomes ◽  
Human Tyrosinase

Potent Melanin Production Enhancement of Human Tyrosinase Gene by Tat and an Entrapment in Elastic Cationic Niosomes: Potential Application in Vitiligo Gene Therapy

2012 ◽  
Vol 80 (6) ◽  
pp. 953-960
Author(s):  
Jiradej Manosroi ◽  
Narinthorn Khositsuntiwong ◽  
Friedrich Götz ◽  
Rolf G. Werner ◽  
Worapaka Manosroi ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Potential Application ◽  
Melanin Production ◽  
Tyrosinase Gene ◽  
Cationic Niosomes ◽  
Human Tyrosinase

Transgenic Medaka Fish Bearing the Mouse Tyrosinase Gene: Expression and Transmission of the Transgene Following Electroporation of the Orange-Colored Variant

1997 ◽  
Vol 10 (3) ◽  
pp. 168-175 ◽  
Author(s):  
HIROTAKE ONO ◽  
EUICHI HIROSE ◽  
KATSUMI MIYAZAKI ◽  
HIROAKI YAMAMOTO ◽  
JIRO MATSUMOTO
Keyword(s):  
Gene Expression ◽  
Medaka Fish ◽  
Tyrosinase Gene

scholarly journals The Organogermanium Compound THGP Suppresses Melanin Synthesis via Complex Formation with L-DOPA on Mushroom Tyrosinase and in B16 4A5 Melanoma Cells

2019 ◽  
Vol 20 (19) ◽  
pp. 4785
Author(s):  
Junya Azumi ◽  
Tomoya Takeda ◽  
Yasuhiro Shimada ◽  
Hisashi Aso ◽  
Takashi Nakamura
Keyword(s):  
Gene Expression ◽  
Kojic Acid ◽  
Biological Activities ◽  
Melanoma Cells ◽  
Tyrosinase Activity ◽  
Melanin Synthesis ◽  
Mushroom Tyrosinase ◽  
Melanin Production ◽  
Organogermanium Compound ◽  
Or Gene

The organogermanium compound 3-(trihydroxygermyl)propanoic acid (THGP) has various biological activities. We previously reported that THGP forms a complex with cis-diol structures. L-3,4-Dihydroxyphenylalanine (L-DOPA), a precursor of melanin, contains a cis-diol structure in its catechol skeleton, and excessive melanin production causes skin darkening and staining. Thus, the cosmetic field is investigating substances that suppress melanin production. In this study, we investigated whether THGP inhibits melanin synthesis via the formation of a complex with L-DOPA using mushroom tyrosinase and B16 4A5 melanoma cells. The ability of THGP to interact with L-DOPA was analyzed by 1H-NMR, and the influence of THGP and/or kojic acid on melanin synthesis was investigated. We also examined the effect of THGP on cytotoxicity, tyrosinase activity, and gene expression and found that THGP interacted with L-DOPA, a precursor of melanin with a cis-diol structure. The results also showed that THGP inhibited melanin synthesis, exerted a synergistic effect with kojic acid, and did not affect tyrosinase activity or gene expression. These results suggest that THGP is a useful substrate that functions as an inhibitor of melanogenesis and that its effect is enhanced by combination with kojic acid.

Tyrosinase Gene Expression in the Kupffer Cells of Rana esculenta L.

2000 ◽  
Vol 13 (6) ◽  
pp. 431-435 ◽  
Author(s):  
GABRIELLA GUIDA ◽  
ANNA GALLONE ◽  
IMMACOLATA MAIDA ◽  
DOMENICO BOFFOLI ◽  
ROSA CICERO
Keyword(s):  
Gene Expression ◽  
Kupffer Cells ◽  
Rana Esculenta ◽  
Tyrosinase Gene

Characteristic sequences in the upstream region of the human tyrosinase gene

1989 ◽  
Vol 1009 (3) ◽  
pp. 283-286 ◽  
Author(s):  
Hideaki Kikuchi ◽  
Hirohito Miura ◽  
Hiroali Yamamoto ◽  
Takuji Takeuchi ◽  
Toshio Dei ◽  
...  
Keyword(s):  
Upstream Region ◽  
Tyrosinase Gene ◽  
Characteristic Sequences ◽  
Human Tyrosinase

scholarly journals A vector for studying plasmid stability functions in Streptomyces

1988 ◽  
Vol 51 (1) ◽  
pp. 71-74 ◽  
Author(s):  
Kevin Kendall ◽  
John Cullum
Keyword(s):  
Copy Number ◽  
Stability Region ◽  
Selectable Marker ◽  
Plasmid Stability ◽  
Stability Function ◽  
Melanin Production ◽  
Stability Functions ◽  
Tyrosinase Gene ◽  
Copy Number Plasmid ◽  
Low Copy Number

SummaryWe constructed a cloning vector (pMT603) based on the low copy number plasmid SCP2*. pMT6O3 is unstable because it lacks the SCP2* stability region and carries the selectable marker thiostrepton-resistance and a tyrosinase gene which results in melanin production. This allows easy testing of plasmid stability and we demonstrated its usefulness by cloning a plasmid stability function.

Polymorphic markers of the human tyrosinase gene for indirect gene diagnosis of tyrosinase-related oculocutaneous albinism (OCA1)

1998 ◽  
Vol 16 ◽  
pp. S149
Author(s):  
Jun Matsunaga ◽  
Muneo Tanita ◽  
Miwako Dakeishi-Hara ◽  
Eriko Nakamura ◽  
Yoshinori Miyamura ◽  
...  
Keyword(s):  
Oculocutaneous Albinism ◽  
Polymorphic Markers ◽  
Gene Diagnosis ◽  
Tyrosinase Gene ◽  
Human Tyrosinase
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