Prognostic significance of body mass index‐adjusted criteria for left ventricular hypertrophy

Background and ObjectivesHigh plasma concentration of fibroblast growth factor 23 (FGF23) is a risk factor for left ventricular hypertrophy (LVH) in adults with CKD, and induces myocardial hypertrophy in experimental CKD. We hypothesized that high FGF23 levels associate with a higher prevalence of LVH in children with CKD.Design, setting, participants, & measurementsWe performed echocardiograms and measured plasma C-terminal FGF23 concentrations in 587 children with mild-to-moderate CKD enrolled in the Chronic Kidney Disease in Children (CKiD) study. We used linear and logistic regression to analyze the association of plasma FGF23 with left ventricular mass index (LVMI) and LVH (LVMI ≥95th percentile), adjusted for demographics, body mass index, eGFR, and CKD-specific factors. We also examined the relationship between FGF23 and LVH by eGFR level.ResultsMedian age was 12 years (interquartile range, 8–15) and eGFR was 50 ml/min per 1.73 m2 (interquartile range, 38–64). Overall prevalence of LVH was 11%. After adjustment for demographics and body mass index, the odds of having LVH was higher by 2.53 (95% confidence interval, 1.28 to 4.97; P<0.01) in participants with FGF23 concentrations ≥170 RU/ml compared with those with FGF23<100 RU/ml, but this association was attenuated after full adjustment. Among participants with eGFR≥45 ml/min per 1.73 m2, the prevalence of LVH was 5.4%, 11.2%, and 15.3% for those with FGF23 <100 RU/ml, 100–169 RU/ml, and ≥170 RU/ml, respectively (Ptrend=0.01). When eGFR was ≥45 ml/min per 1.73 m2, higher FGF23 concentrations were independently associated with LVH (fully adjusted odds ratio, 3.08 in the highest versus lowest FGF23 category; 95% confidence interval, 1.02 to 9.24; P<0.05; fully adjusted odds ratio, 2.02 per doubling of FGF23; 95% confidence interval, 1.29 to 3.17; P<0.01). By contrast, in participants with eGFR<45 ml/min per 1.73 m2, FGF23 did not associate with LVH.ConclusionsPlasma FGF23 concentration ≥170 RU/ml is an independent predictor of LVH in children with eGFR≥45 ml/min per 1.73 m2.

Download Full-text

Influence of age and body mass index on arterial stiffness and left ventricular hypertrophy in patients with arterial hypertension II stage.

Medicni perspektivi (Medical perspectives) ◽

10.26641/2307-0404.2019.3.181875 ◽

2019 ◽

Vol 24 (3) ◽

pp. 22-32

Author(s):

T. V. Kolesnyk ◽

A. V. Nadiuk ◽

H. A. Kosova

Keyword(s):

Body Mass Index ◽

Arterial Stiffness ◽

Left Ventricular Hypertrophy ◽

Arterial Hypertension ◽

Body Mass ◽

Ventricular Hypertrophy ◽

Left Ventricular

Download Full-text

Implications of World Health Organization classification for body mass index on the correlations between common electrocardiographic indexes for left ventricular hypertrophy and left ventricular mass

Clinical and Experimental Hypertension ◽

10.1080/10641963.2016.1200604 ◽

2016 ◽

Vol 38 (8) ◽

pp. 715-720 ◽

Cited By ~ 2

Author(s):

Satoshi Kurisu ◽

Hiroki Ikenaga ◽

Noriaki Watanabe ◽

Tadanao Higaki ◽

Takashi Shimonaga ◽

...

Keyword(s):

Body Mass Index ◽

Left Ventricular Hypertrophy ◽

World Health Organization ◽

Left Ventricular Mass ◽

Body Mass ◽

Ventricular Hypertrophy ◽

Left Ventricular ◽

World Health ◽

World Health Organization Classification ◽

Health Organization

Download Full-text

FREQUENCY AND RISK FACTORS OF LEFT VENTRICULAR GEOMETRIC ABNORMALITIES IN HYPERTENSIVE PATIENTS: A STUDY BASED ON THE UPDATED CLASSIFICATION SYSTEM OF LEFT VENTRICULAR GEOMETRY

Pakistan Armed Forces Medical Journal ◽

10.51253/pafmj.v70isuppl-4.6002 ◽

2021 ◽

Vol 70 (Suppl-4) ◽

pp. S695-700

Author(s):

Fauzia Nazir ◽

Tahir Iqbal ◽

Javeria Kamran ◽

Tariq Hussain Khattak ◽

Anum Fatima ◽

...

Keyword(s):

Diabetes Mellitus ◽

Blood Pressure ◽

Body Mass Index ◽

Left Ventricular Hypertrophy ◽

Systolic Blood Pressure ◽

Body Mass ◽

Ventricular Hypertrophy ◽

Left Ventricular ◽

Concentric Left Ventricular Hypertrophy ◽

Elevated Systolic Blood Pressure

Objective: To determine the association between cardiovascular risk factors and the abnormalities of left ventricular geometric abnormalities. Study Design: Prospective cross-sectional, single centered study. Place and Duration of Study: Armed Forces Institute of Cardiology, Rawalpindi, from Jun 2018 to Dec 2018. Methodology: This study permission was sought from hospital ethics committee. Written informed consent was taken from participants of study. Particulars of all the patients who meet the inclusion were included i.e., 351 hypertensive. Results: Left ventricular geometric abnormalities were detected in 321 subjects (91%), wherein concentric non dilated left ventricular hypertrophy is the most common left ventricular geometric abnormality (39%). Elevated systolic blood pressure and diabetes mellitus were positively associated with concentric left ventricular remodeling, whereas body mass index and chronic kidney disease were inversely associated with concentric abnormalities. systolic blood pressure and diabetes mellitus, chronic kidney disease, large WC were positively associated with eccentric dilated left ventricular hypertrophy, while body mass index, duration of hypertension, MS were inversely associated with eccentric dilated left ventricular hypertrophy. Elevated systolic blood pressure was the strongest risk factor for eccentric dilated left ventricular hypertrophy. Large WC, systolic blood pressure and diabetes mellitus were positively associated with concentric left ventricular hypertrophy, whereas body mass index was negatively associated with concentric left ventricular hypertrophy. Conclusion: Appropriate risk factor management and compliance can prevent left ventricular geometric abnormalities hence poorer outcomes in our population

Download Full-text