scholarly journals The association between type 2 diabetes and anhedonic subtype of major depression in hypertensive individuals

2022 ◽  
Author(s):  
Hadrien Willame ◽  
Benjamin Wacquier ◽  
Camille Point ◽  
Marjorie Dosogne ◽  
Mohammed Al Faker ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Major Depression

scholarly journals Post-Craniopharyngioma and Cranial Nerve-VI Palsy Update on a MS Patient with Major Depression and Concurrent Neuroimmune Conditions

2019 ◽  
Vol 9 (10) ◽  
pp. 281 ◽  
Author(s):  
Navzer D. Sachinvala ◽  
Angeline Stergiou ◽  
Duane E. Haines ◽  
Armen Kocharian ◽  
Andrew Lawton
Keyword(s):  
Multiple Sclerosis ◽  
Type 2 Diabetes ◽  
Major Depression ◽  
Cranial Nerve ◽  
Chronic Conditions ◽  
Magnetic Resonance Image ◽  
Fiber Layer ◽  
Major Depressive ◽  
Nerve Fiber Layer Thickness

We report the case of a male multiple sclerosis (MS) patient with type 2 diabetes (T2D), asthma, major depression (MD or major depressive disorder, MDD), and other chronic conditions, after his recent difficulties with craniopharyngioma and cranial nerve-VI (CN6) palsy. In addition, we show magnetic resonance image and spectroscopy (MRI, MRS), Humphrey’s Visual Field (HVF), and retinal nerve fiber layer thickness (RNFLT) findings to explain the changes in the patient’s health, and discuss the methods that helped/help him sustain productivity and euthymia despite long-standing problems and new CNS changes.

scholarly journals Detection and prevalence of depression among adult type 2 diabetes mellitus patients attending non-communicable diseases clinics in Lilongwe, Malawi

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Michael Udedi ◽  
Brian W. Pence ◽  
Robert C. Stewart ◽  
Adamson S. Muula
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Major Depression ◽  
Sociodemographic Factors ◽  
Adult Type ◽  
Non Communicable Diseases ◽  
Prevalence Of Depression ◽  
Dsm Iv

Abstract Background Depression is associated with chronic physical illnesses and negatively affects health outcomes. However, it often goes undiagnosed and untreated. We investigated the prevalence of depression among adult type 2 diabetes mellitus (T2DM) patients attending non-communicable diseases (NCD) clinics in Lilongwe, Malawi, and estimated the level of routine detection by NCD clinicians. This study set out to determine the prevalence of major depression and its detection among adult type 2 diabetes mellitus (T2DM) patients attending NCD clinics in Lilongwe, Malawi. Methods In a cross-sectional study design, 323 T2DM patients aged ≥ 18 years were screened for depression with the Patient Health Questionnare-9 (PHQ-9) followed by diagnostic assessment with the Structured Clinical Interview for DSM-IV (SCID). We analysed the association between presence of major depression and sociodemographic factors using logistic regression. Results Three quarters of the participants (76%) were females. The participants’ ages ranged from 21–79 years. Of the 323 participants, 58 (18%) met criteria for DSM-IV major depression. None of the cases of major depression had been identified by the NCD clinicians. Major depression was found not to be significantly associated with any of the sociodemographic factors. Conclusions We found that depression is common among NCD clinic attendees with T2DM in Malawi, and poorly detected by NCD clinicians. Given the high prevalence and challenges in clinical identification, integration of depression screening with a standardized validated tool should be a high priority so as to link patients to appropriate services.

scholarly journals Lack of association between type 2 diabetes and major depression: epidemiologic and genetic evidence in a multiethnic population

2015 ◽  
Vol 5 (8) ◽  
pp. e618-e618 ◽  
Author(s):  
Z Samaan ◽  
S Garasia ◽  
H C Gerstein ◽  
J C Engert ◽  
V Mohan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Major Depression ◽  
Genetic Evidence ◽  
Multiethnic Population

scholarly journals Regional cortical gray matter thickness differences associated with type 2 diabetes and major depression

2010 ◽  
Vol 184 (2) ◽  
pp. 63-70 ◽  
Author(s):  
Olusola Ajilore ◽  
Katherine Narr ◽  
Jonah Rosenthal ◽  
Daniel Pham ◽  
Liberty Hamilton ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Major Depression ◽  
Gray Matter ◽  
Cortical Gray Matter

scholarly journals Detection and prevalence of depression among adult type 2 diabetes mellitus patients attending non-communicable diseases clinics in Lilongwe, Malawi

2020 ◽  
Author(s):  
Michael Udedi ◽  
Brian W. Pence ◽  
Robert C. Stewart ◽  
Adamson S. Muula
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Major Depression ◽  
Sociodemographic Factors ◽  
Adult Type ◽  
Non Communicable Diseases ◽  
Prevalence Of Depression ◽  
Dsm Iv

Abstract Background Depression is associated with chronic physical illnesses and negatively affects health outcomes. However, it often goes undiagnosed and untreated. We investigated the prevalence of depression among adult type 2 diabetes mellitus (T2DM) patients attending non-communicable diseases (NCD) clinics in Lilongwe, Malawi, and estimated the level of routine detection by NCD clinicians. This study set out to determine the prevalence of major depression and its detection among adult type 2 diabetes mellitus (T2DM) patients attending NCD clinics in Lilongwe, Malawi. Methods In a cross-sectional study design, 323 T2DM patients aged ≥18 years were screened for depression with the Patient Health Questionnare-9 (PHQ-9) followed by diagnostic assessment with the Structured Clinical Interview for DSM-IV (SCID). We analysed the association between presence of major depression and sociodemographic factors using logistic regression. Results Three quarters of the participants (76%) were females. The participants’ ages ranged from 21-79 years. Of the 323 participants, 58 (18%) met criteria for DSM-IV major depression. None of the cases of major depression had been identified by the NCD clinicians. Major depression was found not to be significantly associated with any of the sociodemographic factors.Conclusions We found that depression is common among NCD clinic attendees with T2DM in Malawi,, and poorly detected by NCD clinicians. Given the high prevalence and challenges in clinical identification, integration of depression screening with a standardized validated tool should be a high priority so as to link patients to appropriate services.

scholarly journals Genetic comorbidity between major depression and cardio-metabolic disease, stratified by age at onset of major depression

2019 ◽  
Author(s):  
SP Hagenaars ◽  
JRI Coleman ◽  
S Choi ◽  
H Gaspar ◽  
MJ Adams ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Body Mass Index ◽  
Coronary Artery ◽  
Major Depression ◽  
Body Mass ◽  
Genetic Correlations ◽  
Polygenic Risk ◽  
Artery Disease

AbstractIntroductionIt’s imperative to understand the specific and shared aetiologies of major depression and cardio-metabolic disease, as both traits are frequently comorbid and each represents a major burden to society. This study examined whether there is a genetic association between major depression and cardio-metabolic traits and if this association is stratified by age at onset for major depression.MethodsPolygenic risk scores analysis and linkage disequilibrium score regression was performed to examine whether differences in shared genetic aetiology exist between depression case control status (N cases = 40,940, N controls = 67,532), earlier (N = 15,844), and later onset depression (N = 15,800) with body mass index, coronary artery disease, stroke, and type 2 diabetes in eleven data sets from the Psychiatric Genomics Consortium, Generation Scotland, and UK Biobank.ResultsAll cardio-metabolic polygenic risk scores were associated with depression status. Significant genetic correlations were found between depression and body mass index, coronary artery disease, and type 2 diabetes. Higher polygenic risk for body mass index, coronary artery disease and type 2 diabetes was associated with both early and later onset depression, while higher polygenic risk for stroke was associated with later onset depression only. Significant genetic correlations were found between body mass index and later onset depression, and between coronary artery disease and both early and late onset depression.ConclusionsThe phenotypic associations between major depression and cardio-metabolic traits may partly reflect their overlapping genetic aetiology irrespective of the age depression first presents.

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