Endoplasmic reticulum stress remodels alveolar bone formation after tooth extraction

Tooth extraction is a dental treatment that is performed frequently in dentistry. This procedure will stimulate a sophisticated healing process involving a variety of biological factors although it takes a long time to complete. Three phases occur in this process i.e. the inflammatory phase, the proliferation phase, and the remodeling phase which aim to restore the tissue function. Several interventions can be used to accelerate bone formation after tooth extraction. Recently, hyaluronic acid (HA) has been commonly used in dentistry due to their essential physiological effects for the periodontal connective tissue, gingiva, and alveolar bone. Hyaluronic acidis a natural non-sulfate glycosaminoglycans compound that has high molecular weight consisting of D-glucuronic acid and N-acetylglucosamine. Hyaluronic acidis also a component of the extracellular matrix that plays an important role in morphogenesis and tissue healing. The mechanism of action of HA works in two ways, that is passive and active mechanism. The passive mechanism is depend on physical and chemical properties of HA that can change the molecular weight and concentration properties. The active mechanism of HA works by stimulating signal transduction pathway initiated by ligand binding with its receptors through autocrine or paracrine processes. The administration of HA can accelerate bone formation due to it can enhance bone morphogenetic protein (BMP) which belongs to the TGF- β superfamily that has high osteogenic capacity. The HA works through a passive mechanism that depends on its molecular weight and an active mechanism by increasing BMP activity.

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Carbonate Apatite Containing Statin Enhances Bone Formation in Healing Incisal Extraction Sockets in Rats

Materials ◽

10.3390/ma11071201 ◽

2018 ◽

Vol 11 (7) ◽

pp. 1201 ◽

Cited By ~ 3

Author(s):

Yunia Rakhmatia ◽

Yasunori Ayukawa ◽

Akihiro Furuhashi ◽

Kiyoshi Koyano

Keyword(s):

Bone Formation ◽

Tooth Extraction ◽

Alveolar Bone ◽

Vertical Plane ◽

Precipitation Reaction ◽

Carbonate Apatite ◽

Mixed Solution ◽

Micro Computed Tomography ◽

Mineral Density ◽

Trabecular Thickness

The purpose of this study was to evaluate the feasibility of using apatite blocks fabricated by a dissolution–precipitation reaction of preset gypsum, with or without statin, to enhance bone formation during socket healing after tooth extraction. Preset gypsum blocks were immersed in a Na3PO4 aqueous solution to make hydroxyapatite (HA) low crystalline and HA containing statin (HAFS), or in a mixed solution of Na2HPO4 and NaHCO3 to make carbonate apatite (CO) and CO containing statin (COFS). The right mandibular incisors of four-week-old male Wistar rats were extracted and the sockets were filled with one of the bone substitutes or left untreated as a control (C). The animals were sacrificed at two and four weeks. Areas in the healing socket were evaluated by micro-computed tomography (micro-CT) and histological analyses. The bone volume, trabecular thickness, and trabecular separation were greatest in the COFS group, followed by the CO, HAFS, HA, and C groups. The bone mineral density of the COFS group was greater than that of the other groups when evaluated in the vertical plane. The results of this study suggest that COFS not only allowed, but also promoted, bone healing in the socket. This finding could be applicable for alveolar bone preservation after tooth extraction.

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Peptide-induced de novo bone formation after tooth extraction prevents alveolar bone loss in a murine tooth extraction model

European Journal of Pharmacology ◽

10.1016/j.ejphar.2016.04.049 ◽

2016 ◽

Vol 782 ◽

pp. 89-97 ◽

Cited By ~ 7

Author(s):

Yuki Arai ◽

Kazuhiro Aoki ◽

Yasuhiro Shimizu ◽

Yasuhiko Tabata ◽

Takashi Ono ◽

...

Keyword(s):

Bone Loss ◽

Bone Formation ◽

Tooth Extraction ◽

Alveolar Bone ◽

De Novo ◽

Alveolar Bone Loss ◽

Extraction Model

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Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation

Nature Cell Biology ◽

10.1038/ncb1963 ◽

2009 ◽

Vol 11 (10) ◽

pp. 1205-1211 ◽

Cited By ~ 198

Author(s):

Tomohiko Murakami ◽

Atsushi Saito ◽

Shin-ichiro Hino ◽

Shinichi Kondo ◽

Soshi Kanemoto ◽

...

Keyword(s):

Endoplasmic Reticulum ◽

Endoplasmic Reticulum Stress ◽

Bone Formation

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OASIS, an endoplasmic reticulum stress transducer, is involved in bone formation

The FASEB Journal ◽

10.1096/fasebj.24.1_supplement.663.2 ◽

2010 ◽

Vol 24 (S1) ◽

Author(s):

Tomohiko Murakami ◽

Riko Nishimura ◽

Toshiyuki Yoneda ◽

Shiro Ikegawa ◽

Kazunori Imaizumi

Keyword(s):

Endoplasmic Reticulum ◽

Endoplasmic Reticulum Stress ◽

Bone Formation

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Effectiveness of Anadara granosa shell-Stichopus hermanni granules at accelerating woven bone formation fourteen days after tooth extraction

Dental Journal (Majalah Kedokteran Gigi) ◽

10.20473/j.djmkg.v52.i4.p177-182 ◽

2019 ◽

Vol 52 (4) ◽

pp. 177

Author(s):

Rima Parwati Sari ◽

Hansen Kurniawan

Keyword(s):

Bone Formation ◽

Tooth Extraction ◽

Alveolar Bone ◽

Extraction Methods ◽

Control Group ◽

Graft Material ◽

Woven Bone ◽

Freeze Dried ◽

Male Wistar Rats ◽

Anadara Granosa

Background: Post-extraction complications can cause alveolar bone resorption. Hydroxyapatite-tricalcium phosphate (HA-TCP) is one potential bone graft material that can be synthesized from Anadara granosa shell. Another biomarine, Stichopus hermanni, contains hyaluronic acid which can accelerate bone formation on the fourteenth day. Purpose: This study aims to prove the effectiveness of Anadara granosa shell-Stichopus hermanni granules in weaving bone formation fourteen days after tooth extraction. Methods: Twenty-five male Wistar rats were divided into five groups. Their lower left incisor was extracted with gelatin being administered to the control group (C) and granule scaffold derived from Anadara granosa (AG) shell and Anadara granosa shell-Stichopus hermanni at concentrations of 0.4%-0.8%-1.6% (AGSH1-AGSH2-AGSH3) to the treatment group. This study developed a HA-TCP synthesized from Anadara granosa combined with whole Stichopus hermanni to create granule scaffolds by means of a freeze-dried method. The jaw was removed on the fourteenth day post-tooth extraction. Observation of HPA involved the use of an Image Raster®. The resulting data was subjected to analysis by ANOVA and tukey-HSD tests (p<0.05). Results: Data showed the mean of C=0.157±0.078; AG=1.139±0.371; AGSH1=1.595±0.291; AGSH2=1.740±0.308; and AGSH3=1.638±0.286. Statistical analyses showed significant differences in the woven bone area (mm2) between C and the treatment groups AG;AGSH1;AGSH2; AGSH3; and between AG and the AGSH2 groups. Conclusions: Scaffold granules from Anadara granosa shells and Stichopus hermanni effectively accelerate the bone formation process with the most effective being Stichopus hermanni at a concentration of 0.8%.

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