scholarly journals Somatic mutations in colorectal cancer are associated with the epigenetic modifications

2020 ◽  
Vol 24 (20) ◽  
pp. 11828-11836
Author(s):  
Hongwei Lei ◽  
Kaixiong Tao
Keyword(s):  
Colorectal Cancer ◽  
Somatic Mutations ◽  
Epigenetic Modifications

Abstract 101: Racial differences in somatic mutations among patients with early-onset colorectal cancer

2021 ◽  
Author(s):  
Andreana N. Holowatyj ◽  
Wanqing Wen ◽  
Timothy Gibbs ◽  
Kay M. Washington ◽  
Paulette D. Chandler ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Racial Differences ◽  
Early Onset ◽  
Somatic Mutations ◽  
Early Onset Colorectal Cancer

scholarly journals Comprehensive Analysis of Somatic Mutations in Colorectal Cancer With Peritoneal Metastasis

In Vivo ◽  
2019 ◽  
Vol 33 (2) ◽  
pp. 447-452 ◽  
Author(s):  
JU-HEE LEE ◽  
BYUNG KYU AHN ◽  
SEUNG SAM BAIK ◽  
KANG HONG LEE
Keyword(s):  
Colorectal Cancer ◽  
Peritoneal Metastasis ◽  
Somatic Mutations ◽  
Comprehensive Analysis

scholarly journals Somatic Mutations in Colorectal Cancer Identify Patients at High-risk of Treatment Failure Following Low-BED Spine Radiotherapy

2020 ◽  
Vol 108 (3) ◽  
pp. e572-e573
Author(s):  
Z.R. Moore ◽  
A. Shamseddine ◽  
E. Lis ◽  
D.S. Higginson ◽  
M. Bilsky ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
High Risk ◽  
Treatment Failure ◽  
Somatic Mutations ◽  
Risk Of Treatment

Novel germline and somatic mutations of the MSH2 gene in hereditary non-polyposis colorectal cancer

2007 ◽  
Vol 71 (2) ◽  
pp. 190-192 ◽  
Author(s):  
D-C Ding ◽  
R-L Huang ◽  
C-H Chen ◽  
C-F Chao ◽  
T-Y Chu
Keyword(s):  
Colorectal Cancer ◽  
Somatic Mutations ◽  
Msh2 Gene

scholarly journals Clinical significance of frequent somatic mutations detected by high-throughput targeted sequencing in archived colorectal cancer samples

2016 ◽  
Vol 14 (1) ◽  
Author(s):  
Ashraf Dallol ◽  
Abdelbaset Buhmeida ◽  
Mahmoud Shaheen Al-Ahwal ◽  
Jaudah Al-Maghrabi ◽  
Osama Bajouh ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Significance ◽  
High Throughput ◽  
Somatic Mutations ◽  
Targeted Sequencing

Biochip detection of KRAS, BRAF, and PIK3CA somatic mutations in colorectal cancer patients

2015 ◽  
Vol 49 (4) ◽  
pp. 550-559 ◽  
Author(s):  
M. A. Emelyanova ◽  
F. A. Amossenko ◽  
A. V. Semyanikhina ◽  
V. A. Aliev ◽  
Yu. A. Barsukov ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Somatic Mutations ◽  
Colorectal Cancer Patients

scholarly journals Deep Next Generation Sequencing Identifies Somatic Mutational Signature in Egyptian Colorectal Cancer Patients

2020 ◽  
Author(s):  
Amira Youssef ◽  
Mohamed A. Abdel-Fattah ◽  
Ahmed O. Touny ◽  
Zeinab K. Hassan ◽  
Auhood Nassar ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Disease Progression ◽  
Pathway Analysis ◽  
Somatic Mutations ◽  
Colonic Polyp ◽  
Control Group ◽  
Data Set ◽  
Inadequate Knowledge ◽  
Colorectal Cancer Patients ◽  
Atm Signaling

Abstract Background: Colorectal cancer (CRC) incidence is progressively increasing in Egypt. Unfortunately, there is inadequate knowledge of the acquired somatic mutations in Egyptian CRC patients which limit our understanding of its progression. To the best of our knowledge, our study is the first to sequence multiple-gene panel to identify the somatic mutation pattern associated with CRC disease progression in a cohort of Egyptian patients. Custom 72 genes, which are frequently associated with CRC, were sequenced using Qiaseq UMI-based targeted DNA panel in 120 fresh tissues classified into; inflammatory bowel disease (IBD; n=20), colonic polyp (CP; n=38) and CRC (n=62) as well as 20 biopsies with non-specific colitis served as a control group (n=20). Results: Using Ingenuity Variant Analysis (IVA), we revealed that APC, TP53 & ATM genes harbored the highly frequent CRC-specific somatic mutations (15, 11 & 6, respectively). We also identified common somatic mutations (predictors) that were associated with disease progression from colitis to CRC; APC (c.1742delA (65%)), TP53 (c.121delG (58%), c.215C>G (52%)), ATM (c.640delT (16%)), IGF2 (c.677delG (56%)), RET (c.2071G>A (37%)), ACVR2A (c.1310delA (26%)), PIK3CA (c.1173A>G (16%)) & KIT (c.1621A>C (13%)). Furthermore, pathway analysis using Ingenuity Pathway Analysis (IPA) showed that Wnt/βcatenin, ATM signaling, RTK-RAS and TGF-β were the most altered pathways in the CRC group (73%. 72%, 40% & 36%, respectively).Conclusion: In this data set, we shed the light on the most frequent somatic mutations and the most altered pathways that are crucial for understanding colorectal cancer predisposition and developing personalized therapies for the Egyptian CRC patients.

scholarly journals P-227 Comparative characteristics of somatic mutations in the KRAS gene in patients with colorectal cancer the South of Russia

2016 ◽  
Vol 27 ◽  
pp. ii66
Author(s):  
O. Kit ◽  
D. Vodolazhsky ◽  
L. Vladimirova ◽  
K. Dvadnenko ◽  
E. Oleynikova ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Somatic Mutations ◽  
The South ◽  
Kras Gene
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