scholarly journals Research Review: The effects of mindfulness‐based interventions on cognition and mental health in children and adolescents – a meta‐analysis of randomized controlled trials

2018 ◽  
Author(s):  
Darren L. Dunning ◽  
Kirsty Griffiths ◽  
Willem Kuyken ◽  
Catherine Crane ◽  
Lucy Foulkes ◽  
...  
Keyword(s):  
Mental Health ◽  
Randomized Controlled Trials ◽  
Children And Adolescents ◽  
Meta Analysis ◽  
Research Review ◽  
Controlled Trials ◽  
Randomized Controlled

scholarly journals The efficacy of app‐supported smartphone interventions for mental health problems: a meta‐analysis of randomized controlled trials

2019 ◽  
Vol 18 (3) ◽  
pp. 325-336 ◽  
Author(s):  
Jake Linardon ◽  
Pim Cuijpers ◽  
Per Carlbring ◽  
Mariel Messer ◽  
Matthew Fuller‐Tyszkiewicz
Keyword(s):  
Mental Health ◽  
Randomized Controlled Trials ◽  
Mental Health Problems ◽  
Meta Analysis ◽  
Health Problems ◽  
Controlled Trials ◽  
Randomized Controlled

scholarly journals Fluoxetine in the Management of Major Depressive Disorder in Children and Adolescents: A Meta-Analysis of Randomized Controlled Trials

2020 ◽  
pp. 001857872092538
Author(s):  
Ayman Antoun Reyad ◽  
Kiran Plaha ◽  
Eriny Girgis ◽  
Raafat Mishriky
Keyword(s):  
Major Depressive Disorder ◽  
Side Effects ◽  
Depressive Disorder ◽  
Randomized Controlled Trials ◽  
Children And Adolescents ◽  
Meta Analysis ◽  
Mean Difference ◽  
Controlled Trials ◽  
Major Depressive ◽  
Randomized Controlled

Background: Fluoxetine is a serotonin-specific reuptake inhibitor antidepressant and is the only approved pharmacological treatment for major depressive disorder (MDD) in children and adolescent. Methods: We searched the published randomized controlled-trials to review fluoxetine efficacy and tolerability using the databases PubMed, EudraCT, ClinicalTrials.gov, and Cochrane Central Register of Controlled Trials for fluoxetine role in managing MDD in children and adolescents. A meta-analysis was conducted using the identified 7 clinical trials to assess efficacy using the outcomes: Children's Depression Rating Scale–Revised (CDRS-R), Clinical Global Impressions–Severity of Illness (CGI-S) and Clinical Global Impressions–Improvement (CGI-I) response rate. The risk of discontinuation due to adverse effects and common side effects were examined. Results: The mean difference in change from baseline for CDRS-R was −2.72 (95% confidence interval [CI], −3.96, −1.48) favoring fluoxetine treatment ( P < .001). Similarly, mean difference for CGI-S was −0.21 (95% CI, −0.36, −0.06). The risk ratio (RR) of discontinuing due to adverse events was 0.98 (95% CI, 0.54, 1.83), with RR for headache side effects 1.34 (95% CI, 1.03, 1.74) and rash 2.6 (95% CI, 1.32, 5.14). Conclusion: Fluoxetine demonstrates significant improvements in symptom intensity control in young patients suffering from MDD and is considered well tolerated with similar rates of trials discontinuation; however, fluoxetine was associated with a higher risk of headache and rash side effects. These findings will guide psychiatrists and pharmacists in their clinical role for supporting the care of young mental health patients.

scholarly journals Immunological and Psychological Efficacy of Meditation/Yoga Intervention Among People Living With HIV (PLWH): A Systematic Review and Meta-analyses of 19 Randomized Controlled Trials

2020 ◽  
Author(s):  
Taiyi Jiang ◽  
Jianhua Hou ◽  
Runsong Sun ◽  
Lili Dai ◽  
Wen Wang ◽  
...  
Keyword(s):  
Mental Health ◽  
T Cell ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Cd4 T Cell ◽  
Controlled Trials ◽  
People Living With Hiv ◽  
Yoga Intervention ◽  
Randomized Controlled ◽  
Cell Counts

Abstract Background An expanding number of mind–body therapies are being used to reduce the psychological burden of peoples living with human immunodeficiency virus (HIV). However, the effects on the immune system and mental health varied among studies. Purpose This meta-analysis was conducted to summarize the randomized controlled trials to draw comprehensive conclusions regarding the psycho-immunological efficacy. Methods Random-effects models were used to assess the outcome of interest. Egger’s tests were used to identify publication bias. Subgroup and meta-regression were used to explore potential moderators. This review was registered on the PROSPERO database (CRD42019148118). Results Nineteen randomized controlled trials with a total sample size of 1,300 were included in this meta-analysis. Regarding immune system outcome, mind–body therapy significantly improved CD4 T-cell counts (Cohen’s d = 0.214, p = .027) and maintained (0.427, p = .049). In addition, baseline CD4 T-cell counts and years since HIV diagnosis significantly moderated the efficacy of mind–body practices on CD4 improvement (all ps &lt; .001). Regarding mental health outcome, mind–body therapy significantly reduced stress, depression, and anxiety symptoms (0.422, p &lt; .001; 0.506, p &lt; .001, and 0.709, p &lt; .001, respectively) while improving quality of life (0.67, p &lt; .001). Conclusions Meditation/yoga intervention could result in potential benefits with regard to improved CD4 T-cell counts immediately after the intervention and at long-term follow-up, while also improving their mental health. The cost-effective meditation/yoga intervention should be integrated into routine care for people living with HIV, especially for those with lower CD4 baseline and fewer years since diagnosis.

scholarly journals The efficacy of smartphone-based mental health interventions for depressive symptoms: a meta-analysis of randomized controlled trials

2017 ◽  
Vol 16 (3) ◽  
pp. 287-298 ◽  
Author(s):  
Joseph Firth ◽  
John Torous ◽  
Jennifer Nicholas ◽  
Rebekah Carney ◽  
Abhishek Pratap ◽  
...  
Keyword(s):  
Mental Health ◽  
Depressive Symptoms ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Health Interventions ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Mental Health Interventions
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