Anti-inflammatory activity of essential oil of an endemicThymus fontanesiiBoiss. & Reut. with chemotype carvacrol, and its healing capacity on gastric lesions

The topical anti-inflammatory activity of the essential oil of Myrtus communis L. was studied using croton oil induced ear edema and myeloperoxidase (MPO) activity in mice, and cotton pellet induced granuloma, and serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in rats. On topical application, the oil exhibited a significant decrease in the ear edema as well as MPO activity. The oil also inhibited cotton pellet-induced granuloma and serum TNF-α and IL-6. It can be concluded that the essential oil of Myrtus communis reduces leukocyte migration to the damaged tissue and exhibits anti-inflammatory activity.

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Anti-edematogenic and anti-inflammatory activity of the essential oil from Croton rhamnifolioides leaves and its major constituent 1,8-cineole (eucalyptol)

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2017.10.005 ◽

2017 ◽

Vol 96 ◽

pp. 384-395 ◽

Cited By ~ 6

Author(s):

Anita Oliveira Brito Pereira Bezerra Martins ◽

Lindaiane Bezerra Rodrigues ◽

Francisco Rafael Alves Santana Cesário ◽

Maria Rayane Correia de Oliveira ◽

Cicera Datiane Morais Tintino ◽

...

Keyword(s):

Essential Oil ◽

Inflammatory Activity ◽

Major Constituent ◽

Anti Inflammatory

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Chemical composition, bactericidal kinetics, mechanism of action, and anti-inflammatory activity of Isodon melissoides (Benth.) H. Hara essential oil

Natural Product Research ◽

10.1080/14786419.2019.1591399 ◽

2019 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Ajay Kumar ◽

Swati Singh ◽

Anant Kumar ◽

Dnyaneshwar Umrao Bawankule ◽

Sudeep Tandon ◽

...

Keyword(s):

Chemical Composition ◽

Essential Oil ◽

Mechanism Of Action ◽

Inflammatory Activity ◽

Anti Inflammatory

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The Essential Oil and Hydrolats from Myristica fragrans Seeds with Magnesium Aluminometasilicate as Excipient: Antioxidant, Antibacterial, and Anti-inflammatory Activity

Foods ◽

10.3390/foods9010037 ◽

2020 ◽

Vol 9 (1) ◽

pp. 37 ◽

Cited By ~ 9

Author(s):

Inga Matulyte ◽

Aiste Jekabsone ◽

Lina Jankauskaite ◽

Paulina Zavistanaviciute ◽

Vytaute Sakiene ◽

...

Keyword(s):

Essential Oil ◽

Biological Activities ◽

Antioxidant Properties ◽

Radical Scavenging ◽

Inflammatory Activity ◽

Poly I:C ◽

Bioactive Substances ◽

Myristica Fragrans ◽

Anti Inflammatory ◽

Nutmeg Essential Oil

Nutmeg (Myristica fragrans) essential oil has antimicrobial, antiseptic, antiparasitic, anti-inflammatory, and antioxidant properties. We have recently demonstrated that hydrodistillation of nutmeg essential oil by applying magnesium aluminometasilicate as an excipient significantly increases both the content and amount of bioactive substances in the oil and hydrolats. In this study, we aimed to compare the antioxidant, antimicrobial, and anti-inflammatory activity of hydrolats and essential oil obtained by hydrodistillation in the presence and absence of magnesium aluminometasilicate as an excipient. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method revealed that magnesium aluminometasilicate did not significantly improved antioxidant activity of both essential oil and hydrolat. Antibacterial efficiency was evaluated by monitoring growth of 15 bacterial strains treated by a range of dilutions of the essential oil and the hydrolats. Essential oil with an excipient completely inhibited the growth of E. faecalis, S. mutans (referent), and P. multocida, whereas the pure oil was only efficient against the latter strain. Finally, the anti-inflammatory properties of the substances were assessed in a fibroblast cell culture treated with viral dsRNR mimetic Poly I:C. The essential oil with an excipient protected cells against Poly I:C-induced necrosis more efficiently compared to pure essential oil. Also, both the oil and the hydrolats with aluminometasilicate were more efficient in preventing IL-6 release in the presence of Poly I:C. Our results show that the use of magnesium aluminometasilicate as an excipient might change and in some cases improve the biological activities of nutmeg essential oil and hydrolats.

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Preliminary Analysis of the Anti-Inflammatory Activity of Essential Oils of Zingiber zerumbet

Biological Research For Nursing ◽

10.1177/1099800410386590 ◽

2010 ◽

Vol 13 (4) ◽

pp. 425-432 ◽

Cited By ~ 9

Author(s):

Z. A. Zakaria ◽

A. S. Mohamad ◽

M. S. Ahmad ◽

A. F. Mokhtar ◽

D. A. Israf ◽

...

Keyword(s):

Side Effects ◽

Essential Oil ◽

Preliminary Analysis ◽

Formalin Test ◽

Inflammatory Activity ◽

Paw Edema ◽

Zingiber Zerumbet ◽

Cotton Pellet ◽

Inflammatory Drugs ◽

Anti Inflammatory

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely used for the treatment of inflammation. However, despite their effectiveness, most NSAIDs cause various side effects that negatively affect the management of inflammation and, in part, pain. Thus, there is a need to search for new anti-inflammatory agents with few, or no, side effects. Natural products of plant, animal, or microorganism origin have been good sources of new bioactive compounds. The present study was carried out to evaluate the acute and chronic anti-inflammatory activities of the essential oil of the rhizomes of Zingiber zerumbet (Zingiberaceae) using the carrageenan-induced paw edema and cotton pellet-induced granuloma tests, respectively. The effect of the essential oil on inflammatory- and noninflammatory-mediated pain was also assessed using the formalin test. Essential oil of Z. zerumbet, at doses of 30, 100, and 300 mg/kg, was administered intraperitoneally to rats. The substance exhibited significant anti-inflammatory activity both in acute and chronic animal models. The essential oil also inhibited inflammatory- and noninflammatory-mediated pain when assessed using the formalin test. In conclusion, the essential oil of Z. zerumbet possessed anti-inflammatory activity, in addition to its antinociceptive activity, which may explain its traditional uses to treat inflammatory-related ailments.

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