Walnut oil alleviates LPS‐induced intestinal epithelial cells injury by inhibiting TLR4/MyD88/NF‐κB pathway activation

2021 ◽  
Author(s):  
Fujun Miao ◽  
Chunlan Shan ◽  
Delu Ning
Keyword(s):  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Walnut Oil ◽  
Pathway Activation

scholarly journals Citrus Peels Phenolic Derivatives Alleviate Benzo[α]pyrene-Induced Inflammatory Injury of Human Intestinal Epithelial Cells Through NLRP3 and AhR Signaling Pathways

2021 ◽  
Author(s):  
Zhuwei Liang ◽  
Huailing Wang ◽  
Dan Luo ◽  
Xiaoyu Liu ◽  
Jie Liu
Keyword(s):  
Epithelial Cells ◽  
Signaling Pathways ◽  
Intestinal Epithelial Cells ◽  
Cell Model ◽  
Intestinal Epithelial ◽  
Human Intestinal Epithelial Cells ◽  
Pathway Activation ◽  
Citrus Peels ◽  
A Cell ◽  
Phenolic Derivatives

Abstract Benzo[α]pyrene (BaP) is ubiquitous in foods, and possesses a fatal cytotoxicity. In current study, ten Citrus peels (Chenpi) phenolic derivatives (CPDs) were isolated in a cell model of human intestinal epithelial (Caco-2) cells under BaP-exposure by a bio-assay guided method. Among them, methyl (3,4,5-trimethoxybenzoyl) valylphenylalaninate (Citrus peels phenolic derivative-2, CPD-2) performed the most protective activity by promoting the antiinflammatory potential on BaP-induced Caco-2 cells. CPD-2 inhibited BaP-induced intracellular ROS over-production and inflammatory epithelial cytokine, IL-4, IL-8, TNF-α, IL-1β and IL-18 over-expression, but not IL-6. CPD-2 also inhibited BaP-induced NLRP3 inflammasome and AhR signaling pathway activation. Overall, CPD-2 attenuates BaP-induced apoptotic death via promoting the antiinflammatory potentials by inhibiting the NLRP3 and AhR signaling pathways activation of Caco-2 cells. Finally, the Citrus peels phenolic derivatives was observed for the first time against BaP-induced inflammation and oxidative stress in human intestinal epithelial cells.

SIRT1/PGC-1 pathway activation triggers autophagy/mitophagy and attenuates oxidative damage in intestinal epithelial cells

Biochimie ◽  
2020 ◽  
Vol 170 ◽  
pp. 10-20 ◽  
Author(s):  
Danyang Liang ◽  
Yisha Zhuo ◽  
Zeheng Guo ◽  
Lihua He ◽  
Xueyi Wang ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Oxidative Damage ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Pathway Activation

Cyanidin-3- O -glucoside inhibits NF-kB signalling in intestinal epithelial cells exposed to TNF-α and exerts protective effects via Nrf2 pathway activation

2016 ◽  
Vol 264 ◽  
pp. 51-58 ◽  
Author(s):  
Daniela Ferrari ◽  
Antonio Speciale ◽  
Mariateresa Cristani ◽  
Deborah Fratantonio ◽  
Maria Sofia Molonia ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Protective Effects ◽  
Intestinal Epithelial ◽  
Nrf2 Pathway ◽  
Pathway Activation ◽  
Tnf Α

Three-dimensional organization and functional relationships of endocytotic compartments in pig intestinal epithelial cells

1992 ◽  
Vol 50 (1) ◽  
pp. 576-577
Author(s):  
Julian P. Heath ◽  
Buford L. Nichols ◽  
László G. Kömüves
Keyword(s):  
Electron Microscopy ◽  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Three Dimensional ◽  
Intestinal Epithelial ◽  
Cell Surfaces ◽  
Basal Surface ◽  
Functional Relationships

The newborn pig intestine is adapted for the rapid and efficient absorption of nutrients from colostrum. In enterocytes, colostral proteins are taken up into an apical endocytotic complex of channels that transports them to target organelles or to the basal surface for release into the circulation. The apical endocytotic complex of tubules and vesicles clearly is a major intersection in the routes taken by vesicles trafficking to and from the Golgi, lysosomes, and the apical and basolateral cell surfaces.Jejunal tissues were taken from piglets suckled for up to 6 hours and prepared for electron microscopy and immunocytochemistry as previously described.

Human and mouse intestinal epithelial cells (IEC) present glycolipid antigens to natural killer (NK)-T cells in a CD1d-restricted manner

2001 ◽  
Vol 120 (5) ◽  
pp. A37-A37
Author(s):  
Y VANDEWAL ◽  
R PITMAN ◽  
R HERSHBERG ◽  
S COLGAN ◽  
S BEHAR ◽  
...  
Keyword(s):  
T Cells ◽  
Epithelial Cells ◽  
Natural Killer ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Nk T Cells ◽  
Human And Mouse

Thrombin enhances migration of intestinal epithelial cells

2001 ◽  
Vol 120 (5) ◽  
pp. A504-A504
Author(s):  
A NEUMANN ◽  
M DEPKAPRONDZINSKI ◽  
C WILHELM ◽  
K FELGENHAUER ◽  
T CASPRITZ ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial

Maintained IL-18bp secretion by intestinal epithelial cells upon selective inhibition of IFN-γ-dependent apoptosis

2009 ◽  
Vol 47 (09) ◽  
Author(s):  
D Schuhmann ◽  
P Godoy ◽  
MV Singer ◽  
S Dooley ◽  
U Böcker
Keyword(s):  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Selective Inhibition ◽  
Intestinal Epithelial ◽  
Ifn Γ
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