scholarly journals Ganglioside GD3 regulates dendritic growth in newborn neurons in adult mouse hippocampus via modulation of mitochondrial dynamics

2020 ◽  
Author(s):  
Fu‐Lei Tang ◽  
Jing Wang ◽  
Yutaka Itokazu ◽  
Robert K. Yu
Keyword(s):  
Dendritic Growth ◽  
Adult Mouse ◽  
Mitochondrial Dynamics ◽  
Mouse Hippocampus ◽  
Newborn Neurons ◽  
Ganglioside Gd3

scholarly journals Live imaging of neurogenesis in the adult mouse hippocampus

Science ◽  
2018 ◽  
Vol 359 (6376) ◽  
pp. 658-662 ◽  
Author(s):  
Gregor-Alexander Pilz ◽  
Sara Bottes ◽  
Marion Betizeau ◽  
David J. Jörg ◽  
Stefano Carta ◽  
...  
Keyword(s):  
Adult Mouse ◽  
Hippocampal Neurogenesis ◽  
Cell Fates ◽  
Comprehensive Description ◽  
Mouse Hippocampus ◽  
Asymmetric Divisions ◽  
Stem And Progenitor Cells ◽  
Newborn Neurons ◽  
Insight Into

Neural stem and progenitor cells (NSPCs) generate neurons throughout life in the mammalian hippocampus. We used chronic in vivo imaging and followed genetically labeled individual NSPCs and their progeny in the mouse hippocampus for up to 2 months. We show that NSPCs targeted by the endogenous Achaete-scute homolog 1 (Ascl1) promoter undergo limited rounds of symmetric and asymmetric divisions, eliciting a burst of neurogenic activity, after which they are lost. Further, our data reveal unexpected asymmetric divisions of nonradial glia-like NSPCs. Cell fates of Ascl1-labeled lineages suggest a developmental-like program involving a sequential transition from a proliferative to a neurogenic phase. By providing a comprehensive description of lineage relationships, from dividing NSPCs to newborn neurons integrating into the hippocampal circuitry, our data offer insight into how NSPCs support life-long hippocampal neurogenesis.

scholarly journals Enhanced plasticity of mature granule cells reduces survival of newborn neurons in the adult mouse hippocampus

2016 ◽  
Author(s):  
Felix Kleine Borgmann ◽  
Johannes Gräff ◽  
Isabelle Mansuy ◽  
Nicolas Toni ◽  
Sebastian Jessberger
Keyword(s):  
Adult Mouse ◽  
Granule Cells ◽  
Mouse Hippocampus ◽  
Newborn Neurons

P.1.03 Effects of chronic citalopram treatment on the kainic acid induced neurogenesis in adult mouse hippocampus

2009 ◽  
Vol 19 ◽  
pp. S132-S133
Author(s):  
K. Jaako ◽  
T. Zharkovskaja ◽  
A. Zharkovsky
Keyword(s):  
Kainic Acid ◽  
Adult Mouse ◽  
Mouse Hippocampus

scholarly journals The impact of maternal separation on adult mouse behaviour and on the total neuron number in the mouse hippocampus

2008 ◽  
Vol 212 (5) ◽  
pp. 403-416 ◽  
Author(s):  
Katrine Fabricius ◽  
Gitta Wörtwein ◽  
Bente Pakkenberg
Keyword(s):  
Adult Mouse ◽  
Maternal Separation ◽  
Neuron Number ◽  
Mouse Behaviour ◽  
Mouse Hippocampus ◽  
The Impact

Loss of PINK1 leads to metabolic deficits in adult neural stem cells and impedes differentiation of newborn neurons in the mouse hippocampus

2017 ◽  
Vol 31 (7) ◽  
pp. 2839-2853 ◽  
Author(s):  
Sandeep Kumar Agnihotri ◽  
Ruifang Shen ◽  
Jihong Li ◽  
Xu Gao ◽  
Hansruedi Büeler
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Adult Neural Stem Cells ◽  
Mouse Hippocampus ◽  
Newborn Neurons

Size Does Matter: Generation of Intrinsic Network Rhythms in Thick Mouse Hippocampal Slices

2005 ◽  
Vol 93 (4) ◽  
pp. 2302-2317 ◽  
Author(s):  
Chiping Wu ◽  
Wah Ping Luk ◽  
Jesse Gillis ◽  
Frances Skinner ◽  
Liang Zhang
Keyword(s):  
In Vitro Model ◽  
Adult Mouse ◽  
Hippocampal Slices ◽  
Network Connectivity ◽  
Slice Preparation ◽  
Fundamental Properties ◽  
Mouse Hippocampus ◽  
Hippocampal Network ◽  
Vitro Model

Rodent hippocampal slices of ≤0.5 mm thickness have been widely used as a convenient in vitro model since the 1970s. However, spontaneous population rhythmic activities do not consistently occur in this preparation due to limited network connectivity. To overcome this limitation, we develop a novel slice preparation of 1 mm thickness from adult mouse hippocampus by separating dentate gyrus from CA3/CA1 areas but preserving dentate–CA3-CA1 connectivity. While superfused in vitro at 32 or 37°C, the thick slice exhibits robust spontaneous network rhythms of 1–4 Hz that originate from the CA3 area. Via assessing tissue O2, K+, pH, synaptic, and single-cell activities of superfused thick slices, we verify that these spontaneous rhythms are not a consequence of hypoxia and nonspecific experimental artifacts. We suggest that the thick slice contains a unitary circuitry sufficient to generate intrinsic hippocampal network rhythms and this preparation is suitable for exploring the fundamental properties and plasticity of a functionally defined hippocampal “lamella” in vitro.

scholarly journals Evidence of Progenitor Cell Lineage Rerouting in the Adult Mouse Hippocampus After Status Epilepticus

2020 ◽  
Vol 14 ◽  
Author(s):  
Daniela M. S. Moura ◽  
Juliana Alves Brandão ◽  
Celia Lentini ◽  
Christophe Heinrich ◽  
Claudio M. Queiroz ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Progenitor Cell ◽  
Adult Mouse ◽  
Cell Lineage ◽  
Mouse Hippocampus
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