High‐resolution magnetic resonance and mass spectrometry imaging of the human larynx

2021 ◽  
Author(s):  
Ayami Ohno Kishimoto ◽  
Yo Kishimoto ◽  
Xudong Shi ◽  
Elizabeth B. Hutchinson ◽  
Hua Zhang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Magnetic Resonance ◽  
High Resolution ◽  
Mass Spectrometry Imaging ◽  
Human Larynx

scholarly journals Mass Spectrometry Imaging Using Dynamically Harmonized FT-ICR at Million Resolving Power: Rationalizing and Optimizing Sample Preparation and Instrumental Parameters

2020 ◽  
Author(s):  
Mathieu Tiquet ◽  
Raphaël La Rocca ◽  
Daan van Kruining ◽  
Pilar Martinez-Martinez ◽  
Gauthier Eppe ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Mass Spectrometry Imaging ◽  
Mass Range ◽  
Maldi Mass Spectrometry ◽  
Mass Accuracy ◽  
Ion Current ◽  
Resolving Power ◽  
Lipid Mass ◽  
The Stability

<p><i>MALDI mass spectrometry imaging (MSI) is a powerful analytical method giving access to the 2D localizations of compounds in a thin section of a sample. To properly discern isobaric compounds in complex biological samples, dynamically harmonized ICR cell (ParaCell©) has been introduce to achieve extreme spectral resolution. However, high resolution MS images realized on a 9.4T FTICR High resolution instrument with recommended parameters suffered from an abnormal shifting of m/z ratios pixel to pixel. Resulting datasets show poor mass accuracy measurements and resolutions under estimations. By following the behavior of the Total Ion Current in function of the number of laser shots, the abnormal mass shifting phenomenon has been linked to the stability of the Total Ion Current (TIC) during images acquisitions. An optimization of laser parameters is proposed in order to limit the observed mass shift to retain machine specifications during MSI analyses. It is also shown that the method has been successfully employed to realize quality MS images with resolution above 1,000,000 in the lipid mass range across the whole image.</i></p>

High-resolution AP-SMALDI mass spectrometry imaging of Drosophila melanogaster

2017 ◽  
Vol 416 ◽  
pp. 1-19 ◽  
Author(s):  
S.M. Khalil ◽  
J. Pretzel ◽  
K. Becker ◽  
B. Spengler
Keyword(s):  
Mass Spectrometry ◽  
Drosophila Melanogaster ◽  
High Resolution ◽  
Mass Spectrometry Imaging

Perspective on Advances in Laser-Based High-Resolution Mass Spectrometry Imaging

2019 ◽  
Vol 92 (1) ◽  
pp. 543-553 ◽  
Author(s):  
Tongtong Wang ◽  
Xiaoling Cheng ◽  
Hexin Xu ◽  
Yifan Meng ◽  
Zhibin Yin ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Mass Spectrometry Imaging ◽  
High Resolution Mass Spectrometry ◽  
High Resolution Mass ◽  
Resolution Mass

Identification of Polychlorobiphenyls by High Resolution Proton Magnetic Resonance

1972 ◽  
Vol 55 (5) ◽  
pp. 1101-1103
Author(s):  
K D Bartle
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Magnetic Resonance ◽  
High Resolution ◽  
Proton Magnetic Resonance ◽  
Chlorine Atoms ◽  
Magnetic Resonance Spectra

Abstract Mass spectrometry allows the number of chlorine atoms per polychlorobiphenyl molecule to be determined but not the positions of substitution. A method of identifying PCB components from high resolution proton magnetic resonance spectra is illustrated by application to 2,5,2′,5′-tetrachloro- and 2,3,4,2′,4′,- 5′-hexachlorobiphenyls separated by gas chromatography from a commercial PCB mixture.

scholarly journals Synthesis of spiro[benzo[4,5]imidazo[2,1-b][1,3]thiazole-2,3-thiolane]s via sulfa-Michael/aldol cascade reactions

2019 ◽  
Vol 43 (1-2) ◽  
pp. 63-66 ◽  
Author(s):  
Jiaying Lei ◽  
Xinliang Fu ◽  
Yulin Huang ◽  
Xiaofang Li
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Crystallographic Analysis ◽  
X Ray ◽  
Resolution Mass

The sulfa-Michael/aldol cascade reaction of ( Z)-2-arylmethylidene-benzo[4,5]imidazo[2,1- b]thiazol-3(2H)-ones and 1,4-dithiane-2,5-diol afforded novel 2-aryl-4-hydroxy-spiro[benzo[4,5]imidazo[2,1- b][1,3]thiazole-2,3-thiolan]-3-ones in moderate yields. The structures of all the products were characterized thoroughly by nuclear magnetic resonance, infrared and high-resolution mass spectrometry together with X-ray crystallographic analysis.

Lateral resolution of desorption nanoelectrospray: a nanospray tip without nebulizing gas as a source of primary charged droplets

The Analyst ◽  
2016 ◽  
Vol 141 (7) ◽  
pp. 2150-2154 ◽  
Author(s):  
L. Hartmanová ◽  
I. Lorencová ◽  
M. Volný ◽  
P. Fryčák ◽  
V. Havlíček ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Mass Spectrometer ◽  
Mass Spectrometry Imaging ◽  
Lateral Resolution ◽  
Charged Droplets ◽  
High Resolution Mass ◽  
Surface Desorption ◽  
High Resolution Mass Spectrometer ◽  
Resolution Mass

Nanoelectrospray directed at the surface (desorption nanoelectrospray) coupled with a high resolution mass spectrometer represents a new tool for mass spectrometry imaging.

High-resolution atmospheric pressure infrared laser desorption/ionization mass spectrometry imaging of biological tissue

2013 ◽  
Vol 405 (22) ◽  
pp. 6959-6968 ◽  
Author(s):  
Andreas Römpp ◽  
Karl Christian Schäfer ◽  
Sabine Guenther ◽  
Zheng Wang ◽  
Martin Köstler ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Biological Tissue ◽  
Atmospheric Pressure ◽  
Mass Spectrometry Imaging ◽  
Laser Desorption ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Desorption Ionization
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