Clinical efficacy of 0.5% topical mangosteen extract in nanoparticle loaded gel in treatment of mild‐to‐moderate acne vulgaris: A 12‐week, split‐face, double‐blinded, randomized, controlled trial

2019 ◽  
Vol 18 (5) ◽  
pp. 1395-1403
Author(s):  
Suparuj Lueangarun ◽  
Karuna Sriviriyakul ◽  
Therdpong Tempark ◽  
Chittima Managit ◽  
Pongtip Sithisarn
Keyword(s):  
Randomized Controlled Trial ◽  
Clinical Efficacy ◽  
Controlled Trial ◽  
Acne Vulgaris ◽  
Randomized Controlled ◽  
Double Blinded ◽  
Split Face

Clinical efficacy of herbal extracts in treatment of mild to moderate acne vulgaris: an 8-week, double-blinded, randomized, controlled trial

2019 ◽  
pp. 1-5 ◽  
Author(s):  
Ji Hoon Yang ◽  
Eun Ju Hwang ◽  
Jungyoon Moon ◽  
Ji Young Yoon ◽  
Ji Won Kim ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Clinical Efficacy ◽  
Controlled Trial ◽  
Acne Vulgaris ◽  
Herbal Extracts ◽  
Randomized Controlled ◽  
Double Blinded

scholarly journals Treatment of Acne Vulgaris With Salicylic Acid Chemical Peel and Pulsed Dye Laser: A Split Face, Rater-Blinded, Randomized Controlled Trial

2015 ◽  
Vol 6 (4) ◽  
pp. 167-170 ◽  
Author(s):  
Olga Lekakh ◽  
Anne Marie Mahoney ◽  
Karlee Novice ◽  
Julia Kamalpour ◽  
Azeen Sadeghian ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Salicylic Acid ◽  
Controlled Trial ◽  
Acne Vulgaris ◽  
Dye Laser ◽  
Pulsed Dye Laser ◽  
Randomized Controlled ◽  
Split Face

scholarly journals SAFETY AND EFFICACY OF DPP4 INHIBITORS IN ACUTE MYOCARDIAL INFARCTION: A BIOMARKER DRIVEN DOUBLE-BLINDED RANDOMIZED CONTROLLED TRIAL

2021 ◽  
Vol 77 (18) ◽  
pp. 58
Author(s):  
Paulo Rizzo Genestreti ◽  
Remo Furtado ◽  
Rocío Salsoso ◽  
Talia Dalcoquio ◽  
Carlos Nakashima ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Safety And Efficacy ◽  
Randomized Controlled ◽  
Dpp4 Inhibitors ◽  
Double Blinded

scholarly journals Clinical efficacy of scaling and root planing with and without metronidazole on glycemic control: three-arm randomized controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ambrina Qureshi ◽  
Syed Akhtar Hussain Bokhari ◽  
Zeba Haque ◽  
Akhtar Ali Baloch ◽  
Sidra Zaheer
Keyword(s):  
Randomized Controlled Trial ◽  
Glycemic Control ◽  
Clinical Efficacy ◽  
Controlled Trial ◽  
Test Group ◽  
Periodontal Pocket ◽  
Outcome Variable ◽  
Scaling And Root Planing ◽  
Randomized Controlled ◽  
Root Planing

Abstract Background Treating periodontitis through non-surgical periodontal therapy (NSPT) may improve glycemic control in type-2 Diabetes Mellitus (T2DM) patients. However, the evidence to maintain this improvement beyond four months is insufficient. Hence, this trial was conducted to assess clinical efficacy of NSPT on glycemic control in T2DM patients. Methods This three-arm randomized controlled trial recruited 150 known T2DM participants (35–65 years), suffering from moderate to severe periodontitis, having HbA1c level ≥ 6.5% at baseline. Participants were followed up at 3 and 6 months. Intervention for test group-1 included scaling and root planing (SRP) with metronidazole (MET) and oral hygiene instructions (OHI). Test group-2 was intervened with SRP + OHI and control group with OHI only. Stata v. 14 was used to observe inter and intragroup mean changes in glycemic [glycated hemoglobin (HbA1c), fasting blood glucose (FBG)] and periodontal variables [bleeding on probing (BOP), periodontal pocket depth (PPD), clinical attachment loss (CAL)] using ANOVA and RMANOVA. Proportion of change in outcome variable (HbA1c) was assessed between treatment groups using chi-square test. Change was considered significant at p-value ≤ 0.05. Results A significant reduction was observed in BOP, PPD, CAL, HbA1c and FBG over time [p < 0.05]. Significant reductions were observed in same variables in both test groups in comparison to control arm [p < 0.05]. No change between the two test groups was observed [p > 0.05]. Conclusion Scaling and root planing improves glycemic control of T2DM patients independently of the use of MET. Therefore, SRP after every 6 months may be suggested and included as a part of overall diabetes management for patients suffering from T2DM. Clinical trial registration NCT 03,343,366 [Date of Registration: 17/11/2017]

scholarly journals Boxing vs Sensory Exercise for Parkinson’s Disease: A Double-Blinded Randomized Controlled Trial

2021 ◽  
pp. 154596832110231
Author(s):  
Kishoree Sangarapillai ◽  
Benjamin M. Norman ◽  
Quincy J. Almeida
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Randomized Controlled Trial ◽  
Repeated Measures ◽  
Rating Scale ◽  
Controlled Trial ◽  
Motor Symptoms ◽  
Post Intervention ◽  
Randomized Controlled ◽  
Double Blinded

Background. Exercise is increasingly becoming recognized as an important adjunct to medications in the clinical management of Parkinson’s disease (PD). Boxing and sensory exercise have shown immediate benefits, but whether they continue beyond program completion is unknown. This study aimed to investigate the effects of boxing and sensory training on motor symptoms of PD, and whether these benefits remain upon completion of the intervention. Methods. In this 20-week double-blinded randomized controlled trial, 40 participants with idiopathic PD were randomized into 2 treatment groups, (n = 20) boxing or (n = 20) sensory exercise. Participants completed 10 weeks of intervention. Motor symptoms were assessed at (week 0, 10, and 20) using the Unified Parkinson’s Disease Rating Scale (UPDRS-III). Data were analyzed using SPSS, and repeated-measures ANOVA was conducted. Results. A significant interaction effect between groups and time were observed F(1, 39) = 4.566, P = .036, where the sensory group improved in comparison to the boxing group. Post hoc analysis revealed that in comparison to boxing, the effects of exercise did not wear off at washout (week 20) P < .006. Conclusion. Future rehabilitation research should incorporate similar measures to explore whether effects of exercise wear off post intervention.

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