Transplantation of autologous fat, stromal vascular fraction (SVF) cell and platelet rich plasma (PRP) for cell therapy of atrophic acne scars: Clinical evaluation and biometric assessment

2021 ◽  
Author(s):  
Mohammad Ali Nilforoushzadeh ◽  
Maryam Heidari‐Kharaji ◽  
Shiva Alavi ◽  
Maryam Nouri ◽  
Nahid Nikkhah ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Clinical Evaluation ◽  
Platelet Rich Plasma ◽  
Stromal Vascular Fraction ◽  
Autologous Fat ◽  
Acne Scars

scholarly journals Transplantation of Autologous Fat, Stromal Vascular Fraction (SVF) Cell and Platelet Rich Plasma (PRP) for Cell Therapy of Atrophic Acne Scars: Clinical Evaluation and Biometric Assessment

2020 ◽  
Author(s):  
Mohammad Ali Nilforoushzadeh ◽  
Maryam Heidari-Kharaji ◽  
Shiva Alavi ◽  
Mona Mahmoudbeyk ◽  
Maryam Nouri ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Imaging System ◽  
Platelet Rich Plasma ◽  
Stromal Vascular Fraction ◽  
Autologous Fat ◽  
Acne Scars ◽  
Therapy Technique ◽  
The Face ◽  
Acne Scarring ◽  
And Migration

Abstract Background: Scarring is an unfortunate result of acne, because it causes psychological and cosmetic problems to patients. Unluckily no single treatment is suitable; using multiple methods may have better result. autologous fat and stromal vascular fraction (SVF) cells and their secretory factors can and enhance angiogenesis, collagen synthesis, and migration of fibroblasts therefore regenerate hurt tissues. Also, other treatments for acne scarring, like platelet rich plasma (PRP), induce the scare improvement. The aim of the study was to verify the effectiveness of transplantation of autologous fat, SVF cells and PRP as cell therapy technique on atrophic acne scars. Methods: This study included 9 adult patients with atrophic acne scars on the face. All patients received transplantation of autologous fat, stromal vascular fraction (SVF) cells and PRP. The treatment outcome was measured by biometric assessment (Visioface 1000 D, Colorimeter, multi probe adapter Cutometer, Tewameter, Mexameter, and skin ultrasound imaging system), also patients’ satisfaction was evaluated. The patients were followed 6 months after treatment. Results: A significant improvement in the skin pores, spots, skin lightness and melanin content of the skin, skin elasticity and TEWL after 6 months of treatment. Also denser skin layers were observed both in the epidermis and dermis. Furthermore, 66.6 % of the patients showed well satisfied after treatment. Conclusion: Briefly, transplantation of autologous fat, SVF cells and PRP is an effective cell therapy for atrophic acne scars.

Split face comparative study of microneedling with platelet rich plasma versus Fractional carbon dioxide laser with platelet rich plasma in treatment of atrophic post acne scars

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mohamed Abd Elnaeem Sallam ◽  
Khaled El Zawahry ◽  
Abdul Rahman Muhammed Ali Mustafa
Keyword(s):  
Carbon Dioxide ◽  
Co2 Laser ◽  
Carbon Dioxide Laser ◽  
Platelet Rich Plasma ◽  
Fractional Co2 Laser ◽  
Acne Scars ◽  
Significant Difference ◽  
Before And After ◽  
The Face ◽  
Fractional Carbon Dioxide Laser

Abstract Background Acne scars, is a challenge for dermatologists, despite having multiple treatment modalities like microneedling, dermabrasion, Fractional CO2 Laser, dermal fillers, etc. However, monotherapy has been hardly satisfactory because of the polymorphism seen with the scars. Objective Comparison between microneedling with platelet rich plasma versus Fractional carbon dioxide laser with platelet rich plasma in treatment of atrophic post acne scars. Patients and methods This study was carried out in department of dermatology, venereology and andrology, in Kobry El-Kobba Military complex during the period (from September 2018 to July 2020 ) on 20 patients of both sexes aged from 20 to 60 years old presenting with Goodman and Baron Grade II, III, IV acne scars . Results The study revealed a statistically significant difference (p = 0.017) between Goodman and Baron scar grades on the right side of the face before and after treatment indicating that microneedling with platelet rich plasma was effective in improving acne scars. Also, there is a statistically significant difference (p = 0.010) between Goodman and Baron scar grades on the left side of the face before and after treatment, indicating that fractional CO2 laser with platelet rich plasma was effective in improving acne scars. Conclusion and recommendation Further controlled and randomized studies are needed to validate our findings in a larger cohort of patients and longer follow up. Also, number of sessions might be more than 3 sessions.

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