Effect of an ashwagandha ( Withania Somnifera ) root extract on climacteric symptoms in women during perimenopause: A randomized, double‐blind , placebo‐controlled study

2021 ◽  
Author(s):  
Sriram Gopal ◽  
Ashutosh Ajgaonkar ◽  
Padmaja Kanchi ◽  
Aditi Kaundinya ◽  
Vaishali Thakare ◽  
...  
Keyword(s):  
Withania Somnifera ◽  
Controlled Study ◽  
Root Extract ◽  
Climacteric Symptoms ◽  
Double Blind ◽  
Double Blind Placebo

A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults

2020 ◽  
Vol 72 ◽  
pp. 28-36 ◽  
Author(s):  
Abhijit Deshpande ◽  
Nushafreen Irani ◽  
Ratna Balkrishnan ◽  
Irin Rosanna Benny
Keyword(s):  
Sleep Quality ◽  
Withania Somnifera ◽  
Healthy Adults ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals Effect of GutGard in the Management ofHelicobacter pylori: A Randomized Double Blind Placebo Controlled Study

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Sreenivasulu Puram ◽  
Hyung Chae Suh ◽  
Seung Un Kim ◽  
Bharathi Bethapudi ◽  
Joshua Allan Joseph ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Treated Group ◽  
Controlled Study ◽  
Root Extract ◽  
Double Blind ◽  
Exact Probability ◽  
Double Blind Placebo ◽  
Significant Difference ◽  
The Difference ◽  
H Pylori

A randomized, double blind placebo controlled study was conducted to evaluate the efficacy of GutGard (root extract ofGlycyrrhiza glabra) in the management ofHelicobacter pylori(H. pylori) gastric load. Participants diagnosed withH. pyloriinfection were randomly assigned to two groups to orally receive 150 mg of GutGard (n=55) or placebo (n=52) once daily for 60 days.H. pyloriinfection was assessed using13C-urea breath test (13C-UBT) at days 0, 30, and 60. Stool Antigen test (HpSA) was also performed on days 0, 30, and 60. Repeated measures of analysis of variance (RMANOVA), chi-square, and Fisher's exact probability tests were used to compare the treatment outcomes. A significant interaction effect between group and time (P=0.00) and significant difference in mean Delta Over Baseline (DOB) values between GutGard (n=50) and placebo (n=50) treated groups after intervention period were observed. On day 60, the results of HpSA test were negative in 28 subjects (56%) in GutGard treated group whereas in placebo treated group only 2 subjects (4%) showed negative response; the difference between the groups was statistically significant. On day 60, the results of13C-UBT were negative in 24 (48%) in GutGard treated group and the difference between the groups was statistically significant. The findings suggest GutGard is effective in the management ofH. pylori.

scholarly journals Red Ginseng Root Extract Mixed with Torilus Fructus and Corni Fructus Improves Facial Wrinkles and Increases Type I Procollagen Synthesis in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study

2009 ◽  
Vol 12 (6) ◽  
pp. 1252-1259 ◽  
Author(s):  
Soyun Cho ◽  
Chong-Hyun Won ◽  
Dong Hun Lee ◽  
Min-Jung Lee ◽  
Serah Lee ◽  
...  
Keyword(s):  
Human Skin ◽  
Ginseng Root ◽  
Controlled Study ◽  
Root Extract ◽  
Type I ◽  
Red Ginseng ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Type I Procollagen ◽  
Corni Fructus

Evaluation of the efficacy of Withania somnifera (Ashwagandha) root extract in patients with obsessive-compulsive disorder: A randomized double-blind placebo-controlled trial

2016 ◽  
Vol 27 ◽  
pp. 25-29 ◽  
Author(s):  
Seyedeh Pardis Jahanbakhsh ◽  
Ali Akhondpour Manteghi ◽  
Seyed Ahmad Emami ◽  
Saman Mahyari ◽  
Beheshteh Gholampour ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Withania Somnifera ◽  
Controlled Trial ◽  
Root Extract ◽  
Obsessive Compulsive ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Compulsive Disorder

Assessment of Withania somnifera root extract efficacy in patients with generalized anxiety disorder: A randomized double-blind placebo-controlled trial

2020 ◽  
Vol 15 ◽  
Author(s):  
Sara Fuladi ◽  
Seyed Ahmad Emami ◽  
Amir Hooshang Mohammadpour ◽  
Asieh Karimani ◽  
Ali Akhondpour Manteghi ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Treatment Group ◽  
Generalized Anxiety Disorder ◽  
Withania Somnifera ◽  
Controlled Trial ◽  
Generalized Anxiety ◽  
Root Extract ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Significant Difference

Background: Anxiety disorders are the most universal psychiatric problems in the general population. Due to their chronic nature, these diseases are managed with a multi-drug regimen lasting for a long period of time. Medication discontinuation leads to 25% and 80% recurrence in the first month and the first year, respectively. Despite several treatment approaches, there is no specific and optimal method for patient management. Therefore, it is necessary to find some new theraputic approaches with fewer side effects. Withania somnifera is a plant with GABAergic property responsible for its anxiolytic effect. The aim of this study was to investigate the effect of W. somnifera root extract as an alternative therapy to reduce standard generalized anxiety disorder (GAD) symptoms. Methods: Forty patients who met the inclusion criteria (with a confirmed diagnosis of GAD as stated in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) took part in this randomized double-blind placebo-controlled trial and were randomly selected for participation in the treatment group (W. somnifera extract, 1g/day; n = 22) or the placebo group (n = 18). All patients were under treatment with Selective Serotonin Reuptake Inhibitors (SSRIs) and were prescribed one capsule of the extract or placebo per day for six weeks. The Hamilton anxiety rating scale (HAM-A) was used to assess the severity of GAD symptoms at baseline as well as the second and sixth weeks of the trial. Results: Comparison of the HAM-A scores during the course of the trial revealed a significant amelioration ofHAM-A score in the treatment group versus placebo (14 and 8 units reduction, respectively (P < 0.05)). Moreover, there was a significant difference in the reduction of GAD score between the second (P =0.04) and sixth week (P =0.02) in the treatment group. The extract was safe and no adverse effect was observed during the trial. Conclusion: W. somnifera extract offers some potential advantages as a safe and effective adjunctive therapy to SSRIs in GAD.

scholarly journals Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study

Cureus ◽  
2019 ◽  
Author(s):  
Deepak Langade ◽  
Subodh Kanchi ◽  
Jaising Salve ◽  
Khokan Debnath ◽  
Dhruv Ambegaokar
Keyword(s):  
Withania Somnifera ◽  
Controlled Study ◽  
Root Extract ◽  
Efficacy And Safety ◽  
Double Blind

105: The Efficacy of Cernilton® in Patients with Chronic Pelvic Pain Syndrome (CP/CPPS) Type Nih IIIA: A Randomized, Prospective, Double-Blind, Placebo Controlled Study

2006 ◽  
Vol 175 (4S) ◽  
pp. 34-34 ◽  
Author(s):  
Henning Schneider ◽  
Martin Ludwig ◽  
Andreas Horstmann ◽  
Jörg Schnitker ◽  
Wolfgang Weidner
Keyword(s):  
Pelvic Pain ◽  
Chronic Pelvic Pain ◽  
Chronic Pelvic Pain Syndrome ◽  
Pain Syndrome ◽  
Controlled Study ◽  
Pelvic Pain Syndrome ◽  
Double Blind ◽  
Double Blind Placebo
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