Atypical preeclampsia without underlying disease and elevated sFlt ‐1/ PlGF ratio

The purpose of this article is to present a general overview of the features of drug-induced movement disorders (DIMDs) comprised by Parkinsonism and extrapyramidal symptoms. Speech-language pathologists (SLPs) who work with patients presenting with these issues must have a broad understanding of the underlying disease process. This article will provide a brief introduction to the neuropathophysiology of DIMDs, a discussion of the associated symptomatology, the pharmacology implicated in causing DIMDs, and the medical management approaches currently in use.

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The importance of underlying disease in patients with gram-negative bacteremia

Archives of Internal Medicine ◽

10.1001/archinte.121.5.418 ◽

1968 ◽

Vol 121 (5) ◽

pp. 418-423 ◽

Cited By ~ 23

Author(s):

M. A. Freid

Keyword(s):

Underlying Disease ◽

Gram Negative ◽

Gram Negative Bacteremia

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Die sFlt-1/PlGF Ratio – neue Serummarker für die Prognose und Prädiktion der Präeklampsie – „from bench to bedside“ in 7 Jahren

Geburtshilfe und Frauenheilkunde ◽

10.1055/s-0031-1295390 ◽

2011 ◽

Vol 71 (11) ◽

Author(s):

S Verlohren ◽

J Pape ◽

T Engels ◽

JW Dudenhausen ◽

E Beinder ◽

...

Keyword(s):

Plgf Ratio

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Outcome of pregnancies with very elevated levels of sFlt-1/PlGF ratio

Geburtshilfe und Frauenheilkunde ◽

10.1055/s-0037-1600042 ◽

2017 ◽

Vol 77 (04) ◽

pp. 379-395

Author(s):

D Wertaschnigg ◽

C Fazelnia ◽

E Doelzmueller ◽

C Kölblinger ◽

C Wohlmuth

Keyword(s):

Plgf Ratio

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Clinical features and outcome of acquired haemophilia A

Hämostaseologie ◽

10.1055/s-0037-1619050 ◽

2010 ◽

Vol 30 (03) ◽

pp. 156-161 ◽

Cited By ~ 9

Author(s):

R. Gheisari ◽

B. Bomke ◽

T. Hoffmann ◽

R. E. Scharf

Keyword(s):

Respiratory Diseases ◽

Care Center ◽

Treatment Algorithm ◽

Early Death ◽

Underlying Disease ◽

Pulmonary Sarcoidosis ◽

Relative Increase ◽

Laboratory Evaluation ◽

Haemophilia A ◽

Acquired Haemophilia

SummaryWe have performed a monocenter study on 29 consecutive patients with acquired haemophilia A who were referred for diagnosis and treatment to the Düsseldorf Haemophilia Comprehensive Care Center between March 2001 and February 2010. Patients, methods: 18 men (age: 44–86 years) and 11 women (age: 20–83 years). For laboratory evaluation, a standardized staged protocol of aPTT, FVIII : C activity and concentration, mixing studies with patient and normal plasma, and quantification of inhibitor titers (Bethesda assay) was used. Diagnostic work-up included elaborate examinations for any underlying disease. Results: In 18 (62%) of the 29 patients with acquired haemophilia A, an underlying disorder was identified, including 9 patients with respiratory diseases (31%), 7 patients with autoimmune disorders (24%), one with malignancy, and one with postpartum state, while in 11 patients (38%) acquired haemophilia A remained idiopathic. Haemotherapy of bleeding, suppression or elimination of the inhibitor, and induction of immunotolerance to endogenous FVIII:C were performed according to a treatment algorithm. Predefined clinical endpoints were control of bleeding, eradication of the inhibitor, complete or partial remission (CR, PR), relapse, or early death (≤30 days). Of the 29 patients in total, 22 individuals achieved CR (76%), three had PR, one relapsed, and three died within 30 days (one of acute myocardial infarction while on anti-haemorrhagic treatment, one of sepsis while on immunosuppression due to active acquired haemophilia A, one of lung bleeding in association with pre-existing pulmonary sarcoidosis). Conclusion: This monocenter study demonstrates that control of life-threatening bleeding, eradication of the inhibitor, and induction of tolerance to endogenous FVIII have significantly improved the clinical outcome of acquired haemophilia A. Our data also suggest a shift in underlying disorders associated with acquired haemophilia A, whereby, in comparison to published studies, a relative increase in the proportion of patients with respiratory diseases is present.

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Morphological features of endo- and myometrium in patients with uterine leiomyoma and infertility

HEALTH OF WOMAN ◽

10.15574/hw.2020.151-152.33 ◽

2020 ◽

pp. 33-37

Author(s):

M.A. Flaksenberg ◽

◽

Keyword(s):

Uterine Leiomyoma ◽

Negative Impact ◽

Reproductive Function ◽

Cell Types ◽

Underlying Disease ◽

Reproductive Organs ◽

Pathological Process ◽

Simple Type ◽

Morphological Examination ◽

Blastocyst Implantation

The objective: determination of morphofunctional features of leiomatous nodes and endometrium in women with uterine leiomyoma and infertility to restore reproductive function and prevent recurrence of the underlying disease. Materials and methods. In order to restore reproductive function and prevent recurrence of the underlying disease, morphofunctional features of leiomatous nodes and endometrium in women with uterine leiomyoma and infertility were determined. Thirty samples of leiomyomatous nodes and endometrium were examined, among which 15 were obtained from women with multiple uterine leiomyoma and infertility and 15 samples from women with uterine leiomyoma with isolated uterine leiomyoma. During the study, a general-histological method was used for staining with hematoxylin-eosin and picrofuxin by van Gizon, as well as immunohistochemical methods. Histological examination of the endometrium was performed according to conventional protocol, taking into account the day of the menstrual cycle and R.W. Noyes criteria. Results. In the morphological examination of leiomyomatous nodes in the vast majority of cases the presence of uterine leiomyomas of simple and cell types or their combination was established. In women with multiple uterine leiomyoma, simple-type leiomyoma (53.3%) was predominant, and in patients with isolated leiomyoma the signs of cellular uterine leiomyoma (66.7%) were more frequently found. In 80.0% of women with uterine leiomyoma revealed pathology of the endometrium, such as glandular and glandular-fibrous polyps, simple and complex atypical endometrial hyperplasia, which confirms the theory about the only pathogenetic mechanisms of the emergence of hyperplastic processes of female organs. In 66.7% of women with multiple leiomyomas, signs of chronic endometritis have been found, which exacerbates the pathological process and can have a negative impact on the reproductive function, such as secretory endometrial transformation and impaired blastocyst implantation, and explains a much higher percentage of infertility in the group. Conclusion. In women with impaired reproductive function, patients with uterine leiomyoma, it is necessary to conduct a study of the receptivity of the reproductive organs, namely - the endometrium and leiomatous nodes. This will make it possible to use one or another method of treatment in order to restore reproductive function and prevent recurrence of the underlying disease. Keywords: infertility, uterine leiomyoma, endometrium, receptive apparatus.

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Faculty Opinions recommendation of Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726058153.793513127 ◽

2016 ◽

Author(s):

Carmine Zoccali ◽

Davide Bolignano

Keyword(s):

Predictive Value ◽

Plgf Ratio

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Epidemiology and Antifungal Susceptibility in Patients with Candidemia in a University Hospital, Thailand

Journal of the Medical Association of Thailand ◽

10.35755/jmedassocthai.2020.10.10822 ◽

2020 ◽

Vol 103 (10) ◽

pp. 1048-1056

Keyword(s):

Antifungal Susceptibility ◽

Underlying Disease ◽

Outcome Data ◽

Adult Patients ◽

Antifungal Treatment ◽

University Hospital ◽

Fluconazole Resistance ◽

Fluconazole Therapy ◽

Fluconazole Resistant ◽

High Level

Background: Candidemia is the most common nosocomial invasive fungal infection that causes high mortality. Emergence of drug-resistant Candida is reported worldwide but there are few studies in Thailand. Objective: To determine the epidemiology, antifungal susceptibility of Candida, and outcomes among adult patients with candidemia. Materials and Methods: A prospective, observational study in adult patients with candidemia was conducted in 2015 at a university hospital. Demographic, microbiological, and outcome data were recorded. Results: Fifty-two patients with candidemia were identified, of whom 76.9% had an underlying disease and 69.2% had risks for candidemia. Sixty-four percent of candidemia patients contracted non-albicans Candida and 36% had Candida albicans. C. tropicalis was the most common non-albicans Candida species isolated (35%), followed by C. parapsilosis (19%), and C. glabrata (10%). Fluconazole resistance was found in 12.5% of C. albicans and in 11.1% of C. parapsilosis isolates. Reduced fluconazole susceptibility or high-level fluconazole resistance was found in 68.7% of C. tropicalis isolates. All except C. parapsilosis had excellent susceptibility to echinocandins. Seventy-three percent (38/52) of patients received antifungal treatment, of whom, 78.9% received empiric fluconazole therapy, and 89.7% were started on antifungal treatment 24 hours after the isolation of Candida. The overall mortality rate was 51.9%. Conclusion: Fluconazole-resistant Candida became more prevalent particularly in C. tropicalis, which was the predominant species among non-albicans Candida causing candidemia. Empiric treatment with either amphotericin B or echinocandins would be appropriate in high-risk patients with suspected candidemia. Trial registration: Thai Clinical Trials Registry, TCTR20150605001 Keywords: Candida, Fluconazole, Resistant, Thailand

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Rare Germline GLMN Variants Identified from Blue Rubber Bleb Nevus Syndrome Might Impact mTOR Signaling

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207322666191203110042 ◽

2020 ◽

Vol 22 (10) ◽

pp. 675-682 ◽

Cited By ~ 1

Author(s):

Jie Yin ◽

Zhongping Qin ◽

Kai Wu ◽

Yufei Zhu ◽

Landian Hu ◽

...

Keyword(s):

Gastrointestinal Tract ◽

Sanger Sequencing ◽

Somatic Mutations ◽

Venous Malformation ◽

Underlying Disease ◽

Mtor Signaling ◽

Functional Effect ◽

Germline Variants ◽

Whole Exome

Backgrounds and Objective: Blue rubber bleb nevus syndrome (BRBN) or Bean syndrome is a rare Venous Malformation (VM)-associated disorder, which mostly affects the skin and gastrointestinal tract in early childhood. Somatic mutations in TEK have been identified from BRBN patients; however, the etiology of TEK mutation-negative patients of BRBN need further investigation. Method: Two unrelated sporadic BRBNs and one sporadic VM were firstly screened for any rare nonsilent mutation in TEK by Sanger sequencing and subsequently applied to whole-exome sequencing to identify underlying disease causative variants. Overexpression assay and immunoblotting were used to evaluate the functional effect of the candidate disease causative variants. Results: In the VM case, we identified the known causative somatic mutation in the TEK gene c.2740C>T (p.Leu914Phe). In the BRBN patients, we identified two rare germline variants in GLMN gene c.761C>G (p.Pro254Arg) and c.1630G>T(p.Glu544*). The GLMN-P254R-expressing and GLMN-E544X-expressing HUVECs exhibited increased phosphorylation of mTOR-Ser-2448 in comparison with GLMN-WTexpressing HUVECs in vitro. Conclusion: Our results demonstrated that rare germline variants in GLMN might contribute to the pathogenesis of BRBN. Moreover, abnormal mTOR signaling might be the pathogenesis mechanism underlying the dysfunction of GLMN protein.

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