Prophylactic Vitamin D Supplementation in High-Risk Breastfed Infants

Objective. To examine the effectiveness of oral vitamin (400 IU) supplementation on the nutritional vitamin D status of breastfeeding infants.Design. As part of a larger ongoing vitamin D RCT trial of lactating women, infants of mothers assigned to control received 1 drop of 400 IU vitamin /day starting at one month of age. Infant 25(OH)D levels (mean S.D.) were measured by RIA at visits 1, 4, and 7.Results. The infant mean S.D. 25(OH)D at baseline was 16.0 9.3 ng/mL (range 1.0–40.8; ); 24 (72.7%) had baseline levels <20 ng/mL (consistent with deficiency). The mean levels increased to 43.6 14.1 (range 18.2–69.7) at 4 months and remained relatively unchanged at month 7: 42.5 12.1 ng/mL (range 18.9–67.2). The change in values between 1 and 4 months and 1 and 7 months was statistically significant , and despite a decrease in dose per kilogram, values were not significantly different between months 4 and 7 .Conclusions. Oral vitamin supplementation as an oil emulsion was associated with significant and sustained increases in 25(OH)D from baseline in fully breastfeeding infants through 7 months.

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Evaluation of Vitamin D Supplementation Doses during Pregnancy in a Population at High Risk for Deficiency

Hormone Research in Paediatrics ◽

10.1159/000358833 ◽

2014 ◽

Vol 81 (6) ◽

pp. 402-408 ◽

Cited By ~ 12

Author(s):

Gul Yesiltepe Mutlu ◽

Elif Ozsu ◽

Sibel Kalaca ◽

Aysegul Yuksel ◽

Yuksel Pehlevan ◽

...

Keyword(s):

Vitamin D ◽

High Risk ◽

Vitamin D Supplementation

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The Spectrum of Vitamin D Deficiency: Description of a Family

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-0043-109699 ◽

2017 ◽

Vol 125 (07) ◽

pp. 478-484 ◽

Cited By ~ 1

Author(s):

Francesco Vierucci ◽

Marta Del Pistoia ◽

Emioli Randazzo ◽

Francesco Massart ◽

Giovanni Federico

Keyword(s):

Risk Factors ◽

Vitamin D ◽

High Risk ◽

Global Health ◽

Vitamin D Deficiency ◽

Family Members ◽

Vitamin D Supplementation ◽

Nutritional Rickets ◽

Clinical Pictures ◽

Global Health Problem

Abstract Background Vitamin D deficiency represents a global health problem, affecting children and adolescents worldwide. Objects To confirm that vitamin D deficiency can present as a spectrum of clinical pictures. Methods We diagnosed nutritional rickets in a 10-month-old infant of Senegal origin with several risk factors for vitamin D deficiency. As many of these factors affected also his cohabitant relatives, we evaluate infant’s family members (mother and 4 brothers) looking for other vitamin D deficiency-related comorbidities. Results 3 brothers had asymptomatic vitamin D deficiency and 2 of them (9.8 and 13.4 years-old) showed secondary hyperparathyroidism. The fourth brother (11.3 years-old) had nutritional rickets. Their mother was affected by osteomalacia. None of them received vitamin D supplementation. Conclusion Vitamin D deficiency may present as a spectrum of clinical pictures, representing a continuum ranging from asymptomatic/subtle conditions to overt rickets/osteomalacia. Immigrant families are at high risk for vitamin D deficiency at every age. If a case of symptomatic vitamin D deficiency is recognized, then the evaluation of the all family members is recommended, as they can have the same and/or other risk factors for vitamin D deficiency.

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Vitamin D status in full-term exclusively breastfed infants versus full-term breastfed infants receiving vitamin D supplementation in Thailand: a randomized controlled trial

BMC Pediatrics ◽

10.1186/s12887-021-02849-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Chayatat Ruangkit ◽

Sukrit Suwannachat ◽

Pornchanok Wantanakorn ◽

Napapailin Sethaphanich ◽

Surapat Assawawiroonhakarn ◽

...

Keyword(s):

Vitamin D ◽

Growth Parameters ◽

Intervention Group ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Full Term ◽

Control Group ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Breastfed Infants

Abstract Background Many international medical organizations recommend vitamin D supplementation for infants, especially exclusively breastfed infants. In Thailand, however, data regarding the vitamin D status in Thai infants are lacking. Such data would help to support physician decisions and guide medical practice. Methods Full-term, exclusively breastfed infants were randomized into two groups at 2 months of age to continue exclusive breastfeeding either without vitamin D supplementation (control group, n = 44) or with vitamin D3 supplementation at 400 IU/day (intervention group, n = 43) until 6 months of age. At 6 months, the serum vitamin D (25OHD) of the infants and their mothers, serum bone marker, and infants’ growth parameters were compared between the two groups. Results The infants’ serum 25OHD concentration was lower in the control group than intervention group (20.57 ± 12.66 vs. 46.01 ± 16.42 ng/mL, p < 0.01). More infants had vitamin D sufficiency (25OHD of > 20 ng/mL) in the intervention group than control group (93.0% vs. 43.2%, p < 0.01). There were no significant differences in the maternal 25OHD concentrations between the control and intervention groups (25.08 ± 7.75 vs. 23.75 ± 7.64 ng/mL, p = 0.42). Serum calcium, phosphorus, intact parathyroid hormone, alkaline phosphatase, and infants’ growth parameters were comparable between the two groups. After adjustment for the confounding factors, 25OHD concentration in the intervention group was 25.66 ng/mL higher than the control group (95% confidence interval, 19.07–32.25; p < 0.001). Vitamin D supplement contributed to an 88.7% decrease in the prevalence of vitamin D insufficiency/deficiency (relative risk, 0.11; 95% confidence interval, 0.04–0.35; p < 0.01). Conclusions Most full-term, exclusively breastfed Thai infants have serum vitamin D concentration below sufficiency level at 6 months of age. However, vitamin D supplementation (400 IU/day) improves their vitamin D status and prevents vitamin D deficiency. Trial registration The study was pre-registered in the Thai Clinical Trials Registry (TCTR20190622001) on 22/06/2019.

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