scholarly journals Maternal Preferences for Vitamin D Supplementation in Breastfed Infants

2017 ◽  
Vol 15 (1) ◽  
pp. 68-70 ◽  
Author(s):  
Puja J. Umaretiya ◽  
Sara S. Oberhelman ◽  
Elizabeth W. Cozine ◽  
Julie A. Maxson ◽  
Stephanie M. Quigg ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Supplementation ◽  
Breastfed Infants ◽  
Maternal Preferences

Does postpartum maternal vitamin D supplementation provide adequate supplementation for exclusively breastfed infants?

2018 ◽  
Vol 21 (9) ◽  
pp. 33-34
Author(s):  
David C. Bury ◽  
P. Clint Bricker ◽  
Kristen Koenig
Keyword(s):  
Vitamin D ◽  
Vitamin D Supplementation ◽  
Maternal Vitamin ◽  
Breastfed Infants

scholarly journals Circulating 25-Hydroxyvitamin D Levels in Fully Breastfed Infants on Oral Vitamin D Supplementation

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Carol L. Wagner ◽  
Cindy Howard ◽  
Thomas C. Hulsey ◽  
Ruth A. Lawrence ◽  
Sarah N. Taylor ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Supplementation ◽  
Vitamin Supplementation ◽  
Oral Vitamin ◽  
Oil Emulsion ◽  
Hydroxyvitamin D ◽  
Breastfed Infants ◽  
25 Hydroxyvitamin D ◽  
The Mean ◽  
Nutritional Vitamin

Objective. To examine the effectiveness of oral vitamin (400 IU) supplementation on the nutritional vitamin D status of breastfeeding infants.Design. As part of a larger ongoing vitamin D RCT trial of lactating women, infants of mothers assigned to control received 1 drop of 400 IU vitamin /day starting at one month of age. Infant 25(OH)D levels (mean S.D.) were measured by RIA at visits 1, 4, and 7.Results. The infant mean S.D. 25(OH)D at baseline was 16.0 9.3 ng/mL (range 1.0–40.8; ); 24 (72.7%) had baseline levels <20 ng/mL (consistent with deficiency). The mean levels increased to 43.6 14.1 (range 18.2–69.7) at 4 months and remained relatively unchanged at month 7: 42.5 12.1 ng/mL (range 18.9–67.2). The change in values between 1 and 4 months and 1 and 7 months was statistically significant , and despite a decrease in dose per kilogram, values were not significantly different between months 4 and 7 .Conclusions. Oral vitamin supplementation as an oil emulsion was associated with significant and sustained increases in 25(OH)D from baseline in fully breastfeeding infants through 7 months.

scholarly journals Prophylactic Vitamin D Supplementation in High-Risk Breastfed Infants

2017 ◽  
Vol 53 (12) ◽  
pp. 1244-1244
Author(s):  
Sarah Pinto ◽  
Philip Bergman ◽  
Justin Brown ◽  
John Welch ◽  
Jacqueline K Hewitt
Keyword(s):  
Vitamin D ◽  
High Risk ◽  
Vitamin D Supplementation ◽  
Breastfed Infants

scholarly journals Vitamin D status in full-term exclusively breastfed infants versus full-term breastfed infants receiving vitamin D supplementation in Thailand: a randomized controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chayatat Ruangkit ◽  
Sukrit Suwannachat ◽  
Pornchanok Wantanakorn ◽  
Napapailin Sethaphanich ◽  
Surapat Assawawiroonhakarn ◽  
...  
Keyword(s):  
Vitamin D ◽  
Growth Parameters ◽  
Intervention Group ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Full Term ◽  
Control Group ◽  
Vitamin D Status ◽  
Serum Vitamin D ◽  
Breastfed Infants

Abstract Background Many international medical organizations recommend vitamin D supplementation for infants, especially exclusively breastfed infants. In Thailand, however, data regarding the vitamin D status in Thai infants are lacking. Such data would help to support physician decisions and guide medical practice. Methods Full-term, exclusively breastfed infants were randomized into two groups at 2 months of age to continue exclusive breastfeeding either without vitamin D supplementation (control group, n = 44) or with vitamin D3 supplementation at 400 IU/day (intervention group, n = 43) until 6 months of age. At 6 months, the serum vitamin D (25OHD) of the infants and their mothers, serum bone marker, and infants’ growth parameters were compared between the two groups. Results The infants’ serum 25OHD concentration was lower in the control group than intervention group (20.57 ± 12.66 vs. 46.01 ± 16.42 ng/mL, p < 0.01). More infants had vitamin D sufficiency (25OHD of > 20 ng/mL) in the intervention group than control group (93.0% vs. 43.2%, p < 0.01). There were no significant differences in the maternal 25OHD concentrations between the control and intervention groups (25.08 ± 7.75 vs. 23.75 ± 7.64 ng/mL, p = 0.42). Serum calcium, phosphorus, intact parathyroid hormone, alkaline phosphatase, and infants’ growth parameters were comparable between the two groups. After adjustment for the confounding factors, 25OHD concentration in the intervention group was 25.66 ng/mL higher than the control group (95% confidence interval, 19.07–32.25; p < 0.001). Vitamin D supplement contributed to an 88.7% decrease in the prevalence of vitamin D insufficiency/deficiency (relative risk, 0.11; 95% confidence interval, 0.04–0.35; p < 0.01). Conclusions Most full-term, exclusively breastfed Thai infants have serum vitamin D concentration below sufficiency level at 6 months of age. However, vitamin D supplementation (400 IU/day) improves their vitamin D status and prevents vitamin D deficiency. Trial registration The study was pre-registered in the Thai Clinical Trials Registry (TCTR20190622001) on 22/06/2019.

scholarly journals Metagenomic analysis of the gut microbiome composition associated with vitamin D supplementation in Taiwanese infants

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Wei-Te Lei ◽  
Kai-Yao Huang ◽  
Jhih-Hua Jhong ◽  
Chia-Hung Chen ◽  
Shun-Long Weng
Keyword(s):  
Vitamin D ◽  
Gut Microbiota ◽  
Gut Microbiome ◽  
Infant Health ◽  
Bone Mineralization ◽  
Vitamin D Supplementation ◽  
Metagenomic Analysis ◽  
Control Group ◽  
Microbiome Composition ◽  
Breastfed Infants

AbstractEarly childhood is a critical stage for the foundation and development of the gut microbiome, large amounts of essential nutrients are required such as vitamin D. Vitamin D plays an important role in regulating calcium homeostasis, and deficiency can impair bone mineralization. In addition, most people know that breastfeeding is advocated to be the best thing for a newborn; however, exclusively breastfeeding infants are not easily able to absorb an adequate amount of vitamin D from breast milk. Understanding the effects of vitamin D supplementation on gut microbiome can improve the knowledge of infant health and development. A total of 62 fecal sample from healthy infants were collected in Taiwan. Of the 62 infants, 31 were exclusively breastfed infants and 31 were mixed- or formula-fed infants. For each feeding type, one subgroup of infants received 400 IU of vitamin D per day, and the remaining infants received a placebo. In total, there are 15 breastfed and 20 formula-fed infants with additional vitamin D supplementation, and 16 breastfed and 11 formula-fed infants belong to control group, respectively. We performed a comparative metagenomic analysis to investigate the distribution and diversity of infant gut microbiota among different types of feeding regimes with and without vitamin D supplementation. Our results reveal that the characteristics of infant gut microbiota not only depend on the feeding types but also on nutrients intake, and demonstrated that the vitamin D plays an important role in modulating the infant gut microbiota, especially increase the proportion of probiotics in breast-fed infants.

Early-Life Effects of Vitamin D: A Focus on Pregnancy and Lactation

2020 ◽  
Vol 76 (2) ◽  
pp. 16-28
Author(s):  
Carol L. Wagner ◽  
Bruce W. Hollis
Keyword(s):  
Vitamin D ◽  
Vitamin D Supplementation ◽  
Vitamin D Metabolism ◽  
Hydroxyvitamin D ◽  
Dihydroxyvitamin D ◽  
Breastfed Infants ◽  
Intention To Treat ◽  
Pregnancy And Lactation ◽  
Maternal Supplementation ◽  
Relative Deficiency

Vitamin D is an endocrine regulator of calcium and bone metabolism. Yet, its effects include other systems, such as innate and adaptive immunity. Unique to pregnancy, circulating 1,25-dihydroxyvitamin D (1,25[OH]<sub>2</sub>D) increases early on to concentrations that are 2–3 times prepregnant values. At no other time during the lifecycle is the conversion of 25-hydroxyvitamin D (25[OH]D) to 1,25(OH)<sub>2</sub>D directly related and optimized at ≥100 nmol/L. Vitamin D deficiency appears to affect pregnancy outcomes, yet randomized controlled trials of vitamin D supplementation achieve mixed results depending on when supplementation is initiated during pregnancy, the dose and dosing interval, and the degree of deficiency at the onset of pregnancy. Analysis of trials on an intention-to-treat basis as opposed to the use of 25(OH)D as the intermediary biomarker of vitamin D metabolism yields differing results, with treatment effects often noted only in the most deficient women. Immediately after delivery, maternal circulating 1,25(OH)<sub>2</sub>D concentrations return to prepregnancy baseline, at a time when a breastfeeding woman has increased demands of calcium, beyond what was needed during the last trimester of pregnancy, making one question why 1,25(OH)<sub>2</sub>D increases so significantly during pregnancy. Is it to serve as an immune modulator? The vitamin D content of mother’s milk is directly related to maternal vitamin D status, and if a woman was deficient during pregnancy, her milk will be deficient unless she is taking higher doses of vitamin D. Because of this relative “deficiency,” there is a recommendation that all breastfed infants receive 400 IU vitamin D<sub>3</sub>/day starting a few days after birth. The alternative – maternal supplementation with 6,400 IU vitamin D<sub>3</sub>/day, effective in safely raising maternal circulating vitamin D, that of her breast milk, and effective in achieving sufficiency in her recipient breastfeeding infant – remains a viable option. Additional research is needed to understand vitamin D’s influence on pregnancy health and the effect of maternal supplementation on breast milk’s immune signaling.

scholarly journals Vitamin D Supplementation Associated with Acute Respiratory Infection in Exclusively Breastfed Infants (P11-071-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Miao Hong ◽  
Ting Xiong ◽  
Junmei Huang ◽  
Yuanjue Wu ◽  
Lixia Lin ◽  
...  
Keyword(s):  
Vitamin D ◽  
Respiratory Infection ◽  
Acute Respiratory Infection ◽  
Basic Research ◽  
Population Based ◽  
Vitamin D Supplementation ◽  
Breastfed Infants ◽  
Funding Sources ◽  
Fundamental Research ◽  
Basic Research Project

Abstract Objectives To investigate the effect of routine oral vitamin D supplementation on acute respiratory infection in exclusively breastfed infants. Methods A retrospective analysis from a multi-center population-based prospective cohort study (TMCHC) in Wuhan, China. We retrospectively analyzed the data on ARI and ARI-related hospitalization experience and the vitamin D supplementation history among the exclusively breastfed infants by 6 months of age, from the TMCHC study. We set the first ARI by 6 months of age as the outcome endpoint, and assessed the infants vitamin D supplementation from birth to the outcome endpoint with or without supplementation and supplementation frequencies (≤ 2 days/week, 3–4 days/week, 5–6 days/week, > 6 days/week). Results Among 983 exclusively breastfed infants, 433 (44%) had an ARI and 55 (6%) experienced ARI-related hospitalization. Infants with vitamin D supplementation experienced a lower cumulative incidence of ARI than those without by 6 months of age (P < 0.001). Vitamin D supplementation was significantly associated with a decreased risk of ARI (OR = 0.19, 95%CI: 0.13-0.30) and ARI-related hospitalization (OR = 0.17, 95%CI: 0.09-0.30) after adjustment for all confounding factors. Additionally, this association represented a dose-response relationship (P for trend < 0.001). Conclusions Vitamin D supplementation was associated with a reduced risk of ARI and ARI-related hospitalization among exclusively breastfed infants by 6 months of age, suggesting that vitamin D supplementation is a promising strategy for acute respiratory infection prevention at early childhood. Funding Sources This study is supported by National Program on Basic Research Project of China (NO.2013FY114200), the Fundamental Research Funds for the Central Universities (NO. HUST2016YXZD040), and the National Natural Science Foundation of China (NO. 81573149). Supporting Tables, Images and/or Graphs

Vitamin D supplementation of Canadian infants: practices of Montreal mothers

2010 ◽  
Vol 35 (3) ◽  
pp. 303-309 ◽  
Author(s):  
Sina Gallo ◽  
Sonia Jean-Philippe ◽  
Celia Rodd ◽  
Hope A. Weiler
Keyword(s):  
Vitamin D ◽  
Vitamin D Supplementation ◽  
Term Infant ◽  
Vitamin Supplementation ◽  
Cross Sectional ◽  
Breastfed Infants ◽  
Healthy Term Infant ◽  
Canadian Population ◽  
Health Canada ◽  
Vitamin D Supplement

Health policy in North America advocates that all breastfed infants receive a vitamin D supplement of 400 IU per day for the primary prevention of rickets. Despite this recommendation, rickets still occurs in Canada. It is not known whether vitamin D deficiency in the Canadian population is solely attributable to inadequacies in vitamin supplementation. Thus, the evaluation of current practices, including awareness and compliance with recommendations, is clearly needed. The objective of this study was to describe the vitamin D supplementation practices of mothers of newborns living in the Montreal area. This was a cross-sectional telephone survey of 343 mothers delivering a healthy term infant from December 2007 to May 2008 at the Royal Victoria Hospital (Montreal, Que.). Ninety percent of all mothers breastfed their infants during the first 6 months; 53% did so exclusively. Of mothers exclusively breastfeeding, 74% reported meeting the Health Canada recommendation. The main reason for not adhering to the recommendation was the assumption by mothers who began to feed fortified formula (400 IU·L–1) that supplementation was no longer necessary. Fifty percent of infants receiving mixed feedings without supplementation prior to 6 months did not achieve the recommended intake. Receiving advice about supplementation and the higher education of mothers were significant positive determinants of supplementation practices. This work identified infants consuming mixed feedings and those consuming only formula in the first 6 months as groups at high risk for not meeting the recommended 400 IU·day–1 of vitamin D. Therefore there may still be gaps in knowledge regarding vitamin D supplementation.

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