Reducing asthma hospitalisations in at‐risk children: A systematic review

2021 ◽  
Author(s):  
Katherine Y H Chen ◽  
Leanne Saxon ◽  
Colin Robertson ◽  
Harriet Hiscock
Keyword(s):  
Systematic Review ◽  
At Risk ◽  
At Risk Children

scholarly journals Common Elements of Practice, Process and Implementation in Out-of-School-Time Academic Interventions for At-risk Children: a Systematic Review

2020 ◽  
Vol 21 (4) ◽  
pp. 545-556 ◽  
Author(s):  
Thomas Engell ◽  
Benedicte Kirkøen ◽  
Karianne Thune Hammerstrøm ◽  
Hege Kornør ◽  
Kristine Horseng Ludvigsen ◽  
...  
Keyword(s):  
Systematic Review ◽  
At Risk ◽  
Academic Interventions ◽  
Common Elements ◽  
Out Of School Time ◽  
School Time ◽  
At Risk Children ◽  
Out Of School

Dental Implant Placement in Patients with a History of Medications Related to Osteonecrosis of the Jaws: A Systematic Review

2020 ◽  
Author(s):  
Judd Sher ◽  
Kate Kirkham-Ali ◽  
Denny Luo ◽  
Catherine Miller ◽  
Dileep Sharma
Keyword(s):  
Systematic Review ◽  
At Risk ◽  
Drug Therapy ◽  
Dental Implant ◽  
Case Series ◽  
Cochrane Central Register ◽  
Bisphosphonate Treatment ◽  
Implant Placement ◽  
Increased Risk ◽  
History Of

The present systematic review evaluates the safety of placing dental implants in patients with a history of antiresorptive or antiangiogenic drug therapy. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were followed. PubMed, Cochrane Central Register of Controlled Trials, Scopus, Web of Science, and OpenGrey databases were used to search for clinical studies (English only) to July 16, 2019. Study quality was assessed regarding randomization, allocation sequence concealment, blinding, incomplete outcome data, selective outcome reporting, and other biases using a modified Newcastle-Ottawa scale and the Joanna Briggs Institute critical appraisal checklist for case series. A broad search strategy resulted in the identification of 7542 studies. There were 28 studies reporting on bisphosphonates (5 cohort, 6 case control, and 17 case series) and one study reporting on denosumab (case series) that met the inclusion criteria and were included in the qualitative synthesis. The quality assessment revealed an overall moderate quality of evidence among the studies. Results demonstrated that patients with a history of bisphosphonate treatment for osteoporosis are not at increased risk of implant failure in terms of osseointegration. However, all patients with a history of bisphosphonate treatment, whether taken orally for osteoporosis or intravenously for malignancy, appear to be at risk of ‘implant surgery-triggered’ MRONJ. In contrast, the risk of MRONJ in patients treated with denosumab for osteoporosis was found to be negligible. In conclusion, general and specialist dentists should exercise caution when planning dental implant therapy in patients with a history of bisphosphonate and denosumab drug therapy. Importantly, all patients with a history of bisphosphonates are at risk of MRONJ, necessitating this to be included in the informed consent obtained prior to implant placement. The James Cook University College of Medicine and Dentistry Honours program and the Australian Dental Research Foundation Colin Cormie Grant were the primary sources of funding for this systematic review.

DNA damage repair gene mutation testing and genetic counseling in men with/without prostate cancer: a systematic review

2020 ◽  
Author(s):  
Nigel Armstrong ◽  
Ruben GW Quek ◽  
Steve Ryder ◽  
Janine Ross ◽  
Titas Buksnys ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Systematic Review ◽  
At Risk ◽  
Dna Damage ◽  
Clinical Trials ◽  
Genetic Counseling ◽  
Mutation Screening ◽  
Dna Damage Repair ◽  
Mutation Testing ◽  
Damage Repair

Background: Ongoing clinical trials are investigating poly(ADP-ribose) polymerase (PARP) inhibitors to target the DNA damage repair (DDR) pathway in prostate cancer. DDR mutation screening will guide treatment strategy and assess eligibility for clinical trials. Materials & methods: This systematic review estimated the rate of DDR mutation testing or genetic counseling among men with or at risk of prostate cancer. Results: From 6856 records, one study fulfilled the inclusion criteria and described men undiagnosed with prostate cancer with a family history of BRCA1/2 mutation who received DDR mutation testing. Conclusion: With only one study included in this first systematic review of DDR mutation testing or genetic counseling in men with or at risk of prostate cancer, more research is warranted.

Un Kilo de Ayuda

2018 ◽  
Author(s):  
Mary Kay Gugerty ◽  
Dean Karlan
Keyword(s):  
At Risk ◽  
Impact Evaluation ◽  
Health Problems ◽  
Health Data ◽  
Outcome Data ◽  
Monitoring Data ◽  
Program Monitoring ◽  
At Risk Children ◽  
The World ◽  
The Right

This case explores two common challenges facing organizations around the world: how to collect the right amount of data, and how to credibly use outcome data collected during program monitoring. Health promoters at Un Kilo de Ayuda (UKA) in Mexico use regularly collected health data on more than 50,000 children to structure their work, track their progress, and identify at-risk children in time to treat health problems. In this case, readers will assess the tradeoffs between actionability and responsibility that UKA faces in determining how much data to collect. They will also examine the challenges of monitoring data on a program’s outcomes instead of outputs, particularly when it comes to asserting a program’s impact on those outcomes. Finally, readers will propose ways to generate credible data on one of the organization’s programs when plans for an impact evaluation fall through.

Protecting Against Delinquency in Early Adolescence With Nonverbal Intelligence and Neighborhood Social Capital

2021 ◽  
pp. 027243162110203
Author(s):  
Glenn D. Walters
Keyword(s):  
At Risk ◽  
Social Capital ◽  
Protective Factors ◽  
Conduct Problems ◽  
Nonverbal Intelligence ◽  
Neighborhood Social Capital ◽  
At Risk Children ◽  
The Matrix ◽  
Childhood Conduct Problems ◽  
Matrix Reasoning

The goal of this study was to test nonverbal intelligence and neighborhood social capital as protective factors against future delinquency in early adolescent youth placed at risk by virtue of their involvement in childhood conduct problems. Analyzing longitudinal data from 3,028 youth (1,565 boys, 1,463 girls) in one cohort of the Longitudinal Study of Australian Children (LSAC) and 3,682 youth (1,896 boys, 1,786 girls) in a second cohort of the LSAC, nonverbal intelligence, as measured by the Matrix Reasoning subscale of the WISC-IV, displayed a consistent moderating effect on the conduct problems–future delinquency relationship. According to these results, conduct problems were slightly but significantly less likely to lead to delinquency when nonverbal intelligence was high than when it was low or moderate. By shielding at-risk children from future delinquency, protective factors like high nonverbal intelligence may provide a means by which delinquency can be prevented or reduced.

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