scholarly journals Genetic background of lumbosacral transitional vertebrae in German shepherd dogs

2021 ◽  
Author(s):  
D. Gluding ◽  
K. F. Stock ◽  
B. Tellhelm ◽  
M. Kramer ◽  
N. Eley
Keyword(s):  
Genetic Background ◽  
German Shepherd ◽  
Lumbosacral Transitional Vertebrae

scholarly journals Prevalence of lumbosacral transitional vertebrae in dogs in the Czech Republic

2014 ◽  
Vol 83 (4) ◽  
pp. 399-403 ◽  
Author(s):  
Iva Fialová ◽  
Michaela Paninárová ◽  
Alois Nečas ◽  
Ladislav Stehlík ◽  
Pavel Proks
Keyword(s):  
Czech Republic ◽  
Cauda Equina ◽  
Lumbosacral Spine ◽  
Type I ◽  
Type Ii ◽  
German Shepherd ◽  
The Czech Republic ◽  
Transitional Vertebra ◽  
Lumbosacral Transitional Vertebra ◽  
Lumbosacral Transitional Vertebrae

Lumbosacral transitional vertebra is a common congenital anomaly of the spine in dogs. It is a predisposing factor for degeneration of the lumbosacral spine and development of cauda equina syndrome or hip dysplasia in affected dogs. The aim of the study was to determine breed predisposition, types, and prevalence of lumbosacral transitional vertebrae in the canine population in the Czech Republic. The value of laterolateral radiographs of the lumbosacral junction in the diagnosis of LTV was also evaluated. Prevalence of lumbosacral transitional vertebrae was determined by reviewing ventrodorsal radiographs of pelvis with an extended hip of 1,878 dogs. Lumbosacral transitional vertebrae were detected in 188 dogs (10%). German Shepherd, Alaskan Malamute and Bohemian Shepherd were found to be highly predisposed breeds. The most common type of lumbosacral transitional vertebra was type II with separation of the first sacral vertebra from sacrum and presence of rudimentary intervertebral space between S1 and the sacral median crest (37.8% of the lumbosacral transitional vertebrae). Type I was detected in 29.2% and the asymmetric type of the lumbosacral transitional vertebra (type III) in 33%. Laterolateral radiograph of the lumbosacral spine was evaluated in 126 dogs from 188 with lumbosacral transitional vertebrae. Rudimentary intervertebral disc space between S1 and S2 in laterolateral radiographs was detected in 100% of lumbosacral transitional vertebrae with type II and III, and was not detected in type I. The findings on lumbosacral transitional vertebrae in the Czech Republic will extend knowledge about the disease. Both ventrodorsal hip-extended and laterolateral radiographs should be recommended for routine screening and reliable differentiation among the three different types of lumbosacral transitional vertebra.

Computer Reconstruction of the Cellular Architecture of the Daphnia Magna Optic Ganglion

1975 ◽  
Vol 33 ◽  
pp. 284-285
Author(s):  
E. R. Macagno ◽  
C. Levinthal
Keyword(s):  
Daphnia Magna ◽  
Genetic Background ◽  
Compound Eye ◽  
Synaptic Connectivity ◽  
Serial Sections ◽  
Cross Sectional ◽  
Small Crustacean ◽  
Optic Ganglion ◽  
Structural Invariance ◽  
High Degree

The optic ganglion of Daphnia Magna, a small crustacean that reproduces parthenogenetically contains about three hundred neurons: 110 neurons in the Lamina or anterior region and about 190 neurons in the Medulla or posterior region. The ganglion lies in the midplane of the organism and shows a high degree of left-right symmetry in its structures. The Lamina neurons form the first projection of the visual output from 176 retinula cells in the compound eye. In order to answer questions about structural invariance under constant genetic background, we have begun to reconstruct in detail the morphology and synaptic connectivity of various neurons in this ganglion from electron micrographs of serial sections (1). The ganglion is sectioned in a dorso-ventra1 direction so as to minimize the cross-sectional area photographed in each section. This area is about 60 μm x 120 μm, and hence most of the ganglion fit in a single 70 mm micrograph at the lowest magnification (685x) available on our Zeiss EM9-S.

Estimation of heritability for hip dysplasia in German Shepherd Dogs in Finland

2000 ◽  
Vol 117 (3) ◽  
pp. 97-103 ◽  
Author(s):  
M. Leppänen ◽  
K. Mäki ◽  
J. Juga ◽  
H. Saloniemi
Keyword(s):  
Hip Dysplasia ◽  
German Shepherd

Novel protective markers for ulcerative colitis in the IL2/IL21 region suggest a common genetic background for ulcerative colitis and celiac disease

2008 ◽  
Vol 46 (09) ◽  
Author(s):  
J Glas ◽  
M Wetzke ◽  
D Roeske ◽  
S Pfennig ◽  
W Klein ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Celiac Disease ◽  
Genetic Background

Molecular genetic background of haemophilia A patients with discrepancy between one-stage and two-stage factor VIII assays

2010 ◽  
Vol 30 (S 01) ◽  
pp. S153-S155
Author(s):  
D. Delev ◽  
S. Pahl ◽  
J. Driesen ◽  
H. Brondke ◽  
J. Oldenburg ◽  
...  
Keyword(s):  
Factor Viii ◽  
Genetic Background ◽  
Molecular Genetic ◽  
Haemophilia A ◽  
Two Stage ◽  
One Stage

Various neuroendocrine tumors in a multiple endocrin neoplasia type 1 family with the same genetic background

2013 ◽  
Author(s):  
Krisztian Sepp ◽  
Eva Csajbok ◽  
Sandor Magony ◽  
Janos Julesz ◽  
Attila Patocs ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Genetic Background

Genetic background of cholesterol absorption efficacy. The role of Niemann–Pick C1-like 1 receptor and its genetic variation in lipid metabolism

2010 ◽  
Vol 151 (34) ◽  
pp. 1376-1383 ◽  
Author(s):  
Mariann Harangi ◽  
István Balogh ◽  
János Harangi ◽  
György Paragh
Keyword(s):  
Genetic Variation ◽  
Lipid Metabolism ◽  
Genetic Background ◽  
Cholesterol Absorption ◽  
Niemann Pick

A Niemann–Pick C1-like-1 egy szterolfelismerő domént tartalmazó membránfehérje, amelyet nagy számban expresszálnak csúcsi felszínükön a bélhámsejtek. Az utóbbi évek vizsgálatai azt igazolták, hogy ez a fehérje szükséges a szabad koleszterin bejutásához a bélhámsejtekbe a bél lumenéből. Biokémiai vizsgálatok azt igazolták, hogy a Niemann–Pick C1-like-1-hez kötődik az ezetimib, amely egy hatékony koleszterinfelszívódást gátló szer. A bélből történő koleszterinfelszívódás ütemében és az ezetimibkezelés hatékonyságában tapasztalt egyéni eltérések hátterében felmerült néhány Niemann–Pick C1-like-1 génvariáció oki szerepe.

The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. III. Effect of H-2 haplotype and sex

Diabetes ◽  
1981 ◽  
Vol 30 (12) ◽  
pp. 1029-1034 ◽  
Author(s):  
E. H. Leiter ◽  
D. L. Coleman ◽  
K. P. Hummel
Keyword(s):  
Genetic Background
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