Plasma N-Terminal Probrain Natriuretic Peptide, Vascular Endothelial Growth Factor, and Cardiac Troponin I as Novel Biomarkers of Hypertensive Disease and Target Organ Damage in Cats

The authors’ report presents a brief review of the key studies, providing the reason for the use of vascular endothelial growth factor as a marker for stratification of the risk of cardiovascular complications in patients with essential hypertension.

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Serum Vascular Endothelial Growth Factor VEGF and Interlukin-8 As a Novel Biomarkers For Early Detection of Ovarian Tumors

Baghdad Science Journal ◽

10.21123/bsj.12.2.293-300 ◽

2015 ◽

Vol 12 (2) ◽

pp. 293-300

Author(s):

Baghdad Science Journal

Keyword(s):

Ovarian Cancer ◽

Vascular Endothelial Growth Factor ◽

Serum Levels ◽

Elisa Test ◽

Ovarian Tumors ◽

Benign Tumors ◽

Vascular Endothelial ◽

Additional Tool ◽

Novel Biomarkers ◽

Endothelial Growth Factor

Epithelial ovarian cancer is the leading cause of cancer deaths from gynecological malignancies. Angiogenesis is considered essential for tumor growth and the development of metastases. VEGF and IL?8 are potent angiostimulatory molecules and their expression has been demonstrated in many solid tumors, including ovarian cancer.VEGF and IL-8 concentrations were measured by ELISA test (HumanVEGF,IL-8). Bioassay ELISA/ US Biological / USA).The median VEGF and IL-8 levels were significantly higher in the sera of ovarian cancer patients than in those with benign tumors and in healthy controls.Pretreatment VEGF and IL-8 serum levels might be regarded as an additional tool in the differentiation of ovarian tumors.

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Vascular Endothelial Growth Factor and Soluble Vascular Endothelial Growth Factor Receptor as Novel Biomarkers for Poor Outcomes in Children With Severe Sepsis and Septic Shock

Pediatric Emergency Care ◽

10.1097/pec.0000000000001638 ◽

2018 ◽

Vol Publish Ahead of Print ◽

Cited By ~ 3

Author(s):

Jane E. Whitney ◽

Melanie Silverman ◽

Jackson S. Norton ◽

Richard G. Bachur ◽

Elliot Melendez

Keyword(s):

Septic Shock ◽

Vascular Endothelial Growth Factor ◽

Severe Sepsis ◽

Growth Factor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Novel Biomarkers ◽

Poor Outcomes ◽

Sepsis And Septic Shock ◽

Endothelial Growth Factor

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781 Association between leptin, C-Peptide, Vascular-Endothelial-Growth-Factor (VEGF), Placental-Growth-Factor (PIGF) and hypertensive disease in women with Type-2-Diabetes-Mellitus

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2020.12.804 ◽

2021 ◽

Vol 224 (2) ◽

pp. S487-S488

Author(s):

Asha N. Talati ◽

Amber Ivins ◽

Nicole Wilson ◽

Elizabeth Teal ◽

Kathleen Drexler ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Placental Growth Factor ◽

Vascular Endothelial ◽

Hypertensive Disease ◽

C Peptide ◽

Endothelial Growth Factor

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Vascular endothelial growth factor promotes cardiomyocyte differentiation of embryonic stem cells

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.00363.2005 ◽

2006 ◽

Vol 291 (4) ◽

pp. H1653-H1658 ◽

Cited By ~ 53

Author(s):

Yu Chen ◽

Ivo Amende ◽

Thomas G. Hampton ◽

Yinke Yang ◽

Qingen Ke ◽

...

Keyword(s):

Stem Cells ◽

Vascular Endothelial Growth Factor ◽

Embryonic Stem Cells ◽

Growth Factor ◽

Troponin I ◽

Embryonic Stem ◽

Vegf Receptor ◽

Vascular Endothelial ◽

Cardiomyocyte Differentiation ◽

Endothelial Growth Factor

Embryonic stem cells (ESCs) overexpressing the vascular endothelial growth factor (VEGF) improve cardiac function in mouse models of myocardial ischemia and infarction by mechanisms that are poorly understood. Here we studied the effects of VEGF on cardiomyocyte differentiation of mouse ESCs in vitro. We used flow cytometry to determine the expression of α-myosin heavy chain (α-MHC), cardiac troponin I (cTn-I), and Nkx2.5 in differentiated ESCs. VEGF (20 ng/ml) significantly enhanced α-MHC, cTn-I, and Nkx2.5 expression in differentiated ESCs. Western blot analysis confirmed these findings. We found that VEGF receptor FMS-like tyrosine kinase-1 (Flt-1) and fetal liver kinase-1 (Flk-1) expression increased during ESC differentiation. Antibodies against Flk-1 totally blocked and against Flt-1 partially blocked VEGF-induced NKx2.5-positive-stained cells. The ERK inhibitor PD-098059 abolished VEGF-induced cardiomyocyte differentiation of ESCs. Our results suggest that VEGF promotes cardiomyocyte differentiation predominantly by ERK-mediated Flk-1 activation and, to a lesser extent, by Flt-1 activation. These findings may be of significance for stem cell and growth factor therapies to regenerate failing cardiomyocytes.

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Potential Novel Biomarkers for Diabetic Testicular Damage in Streptozotocin-Induced Diabetic Rats: Nerve Growth Factor Beta and Vascular Endothelial Growth Factor

Disease Markers ◽

10.1155/2014/108106 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 18

Author(s):

Ali Rıza Sisman ◽

Muge Kiray ◽

Ulas Mehmet Camsari ◽

Merve Evren ◽

Mehmet Ates ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Nerve Growth Factor ◽

Growth Factor ◽

Diabetic Rats ◽

Vascular Endothelial ◽

Testicular Damage ◽

Nerve Growth ◽

Novel Biomarkers ◽

Growth Factor Beta ◽

Endothelial Growth Factor

Background. It is well known that diabetes mellitus may cause testicular damage. Vascular endothelial growth factor (VEGF) and nerve growth factor beta (NGF-β) are important neurotrophic factors for male reproductive system.Objective. We aimed to investigate the correlation between testicular damage and testicular VEGF and NGF-βlevels in diabetic rats.Methods. Diabetes was induced by streptozotocin (STZ, 45 mg/kg/i.p.) in adult rats. Five weeks later testicular tissue was removed; testicular VEGF and NGF-βlevels were measured by ELISA. Testicular damage was detected by using hematoxylin and eosin staining and periodic acid-Schiff staining, and apoptosis was identified by terminal-deoxynucleotidyl-transferase-mediated dUTP nick end labeling (TUNEL). Seminiferous tubular sperm formation was evaluated using Johnsen’s score.Results. In diabetic rats, seminiferous tubule diameter was found to be decreased; basement membrane was found to be thickened in seminiferous tubules and degenerated germ cells. Additionally, TUNEL-positive cells were increased in number of VEGF+ cells and levels of VEGF and NGF-βwere decreased in diabetic testes. Correlation between VEGF and NGF-βlevels was strong.Conclusion. These results suggest that the decrease of VEGF and NGF-βlevels is associated with the increase of the apoptosis and testicular damage in diabetic rats. Testis VEGF and NGF-βlevels could be potential novel biomarkers for diabetes induced testicular damage.

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