First histopathological bridging of the distance between Onufʼs nucleus and substantia nigra after olfactory bulbectomy—new ideas about the urinary dysfunction in cerebral neurodegenerative disease: an experimental study

2020 ◽  
Author(s):  
Ayhan Kanat ◽  
Mehmet Dumlu Aydin ◽  
Nezih Akca ◽  
Sevilay Ozmen
Keyword(s):  
Experimental Study ◽  
Substantia Nigra ◽  
Neurodegenerative Disease ◽  
Olfactory Bulbectomy ◽  
Urinary Dysfunction ◽  
New Ideas

‘Too humble and sad’: The effect of humility and emotional display when a politician talks about a moral issue

2019 ◽  
Vol 58 (4) ◽  
pp. 660-680 ◽  
Author(s):  
Francesca D’Errico
Keyword(s):  
Experimental Study ◽  
Positive Emotions ◽  
Negative Association ◽  
Moral Issue ◽  
The Political ◽  
Personal Distress ◽  
Psychological Feature ◽  
Emotional Display ◽  
New Ideas ◽  
Persuasive Effect

Humble leadership can be defined as a positive psychological feature that allows for admitting one’s own limitations, being open to new ideas and giving a voice to, and recognizing the merits of, others. Humility has been associated with positive emotions, like gratitude and elevation, however it has been neglected in the political domain, seen on the contrary as the management of power. The present experimental study was aimed at exploring the possible persuasive effect of a humble politician by considering the role played by emotional display (joy, calm, sadness and anger) when the politician discusses an ethical issue (such as hosting immigration). Contrary to our expectations, humble communication elicited negative emotions and evaluations of the politician, especially when the politician exhibited a sad facial display; further, it induced in voters a state of personal distress towards immigrants, and thus a negative association with a hosting orientation.

Experimental study of serum substantia nigra neuron autoantibody and its effect in Parkinson disease patients

2001 ◽  
Vol 21 (4) ◽  
pp. 280-282 ◽  
Author(s):  
Chen Jixiang ◽  
Cao Xuebing ◽  
Xu Yan ◽  
Sun Shenggang
Keyword(s):  
Experimental Study ◽  
Substantia Nigra ◽  
Parkinson Disease ◽  
Substantia Nigra Neuron

scholarly journals Nanostructure Lipid Carriers Enhance Alpha-Mangostin Neuroprotective Efficacy In Mice With Rotenone-Induced Neurodegeneration

2021 ◽  
Author(s):  
Romkase Sakamula ◽  
Teerapong Yata ◽  
Wachiryah Thong-asa
Keyword(s):  
Superoxide Dismutase ◽  
Motor Cortex ◽  
Substantia Nigra ◽  
Neurodegenerative Disease ◽  
Neuroprotective Effect ◽  
Neuronal Loss ◽  
Natural Antioxidants ◽  
Motor Deficits ◽  
Nissl Staining ◽  
Neuroprotective Effects

Abstract Neurodegenerative disease, for instance, Parkinson’s disease (PD), is associated with substantia nigra dopaminergic neuronal loss with subsequent striatal dopamine reduction, leading to motor deficits. Currently, there is no available effective therapy for PD; thus, novel therapeutic agents such as natural antioxidants with neuroprotective effects are emerging. Alpha-mangostin (αM) is a xanthone derivative compound from mangosteen peel with a cytoprotective effect depicted in neurodegenerative disease models. However, αM has low aqueous solubility and low biodistribution in the brain. Nanostructured lipid carriers (NLC) have been used to encapsulate bioactive compounds delivered to target organs to improve the oral bioavailability and effectiveness. This study aimed to investigate the effect of αM and αM encapsulated in NLC (αM-NLC) in mice with rotenone-induced PD-like neurodegeneration. Forty male ICR mice were divided into normal, PD, PD+αM, and PD+ αM-NLC groups. Vehicle, αM (25 mg/kg/48 h), and αM-NLC (25 mg/kg/48 h) were orally administered, along with PD induction by intraperitoneal injection of rotenone (2.5 mg/kg/48 h) for 4 consecutive weeks. Motor abilities were assessed once a week using rotarod and hanging wire tests. Biochemical analysis of brain oxidative status was conducted, and neuronal populations in substantia nigra par compacta (SNc), striatum, and motor cortex were evaluated using Nissl staining. Tyrosine hydroxylase (TH) immunostaining of SNc and striatum was also evaluated. Results showed that rotenone significantly induced motor deficits concurrent with significant SNc, striatum, and motor cortex neuronal reduction and significantly decreased TH intensity in SNc (p < 0.05). The significant reduction of brain superoxide dismutase activity (p < 0.05) was also detected. Administrations of αM and αM-NLC significantly reduced motor deficits, prevented the reduction of TH intensity in SNc and striatum, and prevented the reduction of neurons in SNc (p < 0.05). Only αM-NLC significantly prevented the reduction of neurons in both striatum and motor cortex (p < 0.05). These were found concurrent with significantly reduced malondialdehyde level and increased catalase and superoxide dismutase activities (p < 0.05). Therefore, this study depicted the neuroprotective effect of αM and αM-NLC against rotenone-induced PD-like neurodegeneration in mice. We indicated an involvement of NLC, emphasizing the protective effect of αM against oxidative stress. Moreover, αM-NLC exhibited broad protection against rotenone-induced neurodegeneration that was not limited to nigrostriatal structures and emphasized the benefit of NLC in enhancing αM neuroprotective effects.

scholarly journals Progressive supranuclear palsy: new concepts

2010 ◽  
Vol 68 (6) ◽  
pp. 938-946 ◽  
Author(s):  
Orlando Graziani Povoas Barsottini ◽  
André Carvalho Felício ◽  
Camila Catherine Henriques de Aquino ◽  
José Luiz Pedroso
Keyword(s):  
Basal Ganglia ◽  
Substantia Nigra ◽  
Neurodegenerative Disease ◽  
Progressive Supranuclear Palsy ◽  
Neurofibrillary Tangles ◽  
Dentate Nucleus ◽  
Treatment Approach ◽  
Red Nucleus ◽  
Oculomotor Nucleus ◽  
New Concepts

Progressive supranuclear palsy (PSP) is a distinctive form of neurodegenerative disease which affects the brainstem and basal ganglia. Patients present supranuclear ophthalmoplegia, postural instability and mild dementia. PSP is defined neuropathologically by the accumulation of neurofibrillary tangles in the subthalamic nucleus, pallidum, red nucleus, substantia nigra, striatum, pontine tegmentum, oculomotor nucleus, medulla and dentate nucleus. Over the last decade many lines of investigations have helped refine PSP in many aspects and it is the purpose of this review to help neurologists identify PSP, to better understand its pathophysiology and to provide a more focused, symptom-based treatment approach.

3.149 AN EXPERIMENTAL STUDY OF ESTABLISHING PD DYSKINESIA MODEL THROUGH COMPLETE DAMAGE TO SUBSTANTIA NIGRA IN RATS

2012 ◽  
Vol 18 ◽  
pp. S201
Author(s):  
C. Chen ◽  
R. Wang ◽  
H. Tan ◽  
M. Shao
Keyword(s):  
Experimental Study ◽  
Substantia Nigra

Experimental study on the restoration from a tilt-azimuth series for improvement in resolution

1995 ◽  
Vol 53 ◽  
pp. 636-637
Author(s):  
Norio Baba ◽  
Norihiko Ichise ◽  
Syunya Watanabe
Keyword(s):  
Experimental Study ◽  
Spherical Aberration ◽  
Incident Beam ◽  
Optical Parameters ◽  
Beam Tilting ◽  
Illumination Method ◽  
Restoration Method ◽  
Illumination Mode

The tilted beam illumination method is used to improve the resolution comparing with the axial illumination mode. Using this advantage, a restoration method of several tilted beam images covering the full azimuthal range was proposed by Saxton, and experimentally examined. To make this technique more reliable it seems that some practical problems still remain. In this report the restoration was attempted and the problems were considered. In our study, four problems were pointed out for the experiment of the restoration. (1) Accurate beam tilt adjustment to fit the incident beam to the coma-free axis for the symmetrical beam tilting over the full azimuthal range. (2) Accurate measurements of the optical parameters which are necessary to design the restoration filter. Even if the spherical aberration coefficient Cs is known with accuracy and the axial astigmatism is sufficiently compensated, at least the defocus value must be measured. (3) Accurate alignment of the tilt-azimuth series images.

Immunocytochemical methodology for the localization of neuronal antigens at the ultrastructural level

1990 ◽  
Vol 48 (3) ◽  
pp. 876-877
Author(s):  
Jorge Pecci Saavedra ◽  
Mark Connaughton ◽  
Juan José López ◽  
Alicia Brusco
Keyword(s):  
Spinal Cord ◽  
Substantia Nigra ◽  
Polyclonal Antibodies ◽  
Ultrastructural Level ◽  
Point Of View ◽  
Nerve Tissue ◽  
Tissue Fixation ◽  
Optimal Conditions ◽  
Interpeduncular Nucleus ◽  
Technical Point

The use of antibodies as labels for the localization of specific molecules in the nervous systan has been extensively applied in recent years. Both monoand polyclonal antibodies or antisera have been employed. The knowledge of the organization of neuronal connectivities, gliovascular relationships, glioneuronal relationships and other features of nerve tissue has greatly increased.A number of areas of the nervous systan have been analyzed in our laboratory, including the nuclei of the raphe system, the reticular formation, interpeduncular nucleus, substantia nigra, caudate nucleus, putamen, pallidum, spinal cord, pineal gland and others.From a technical point of view, a number of variables needed to be taken into account in order to obtain reliable and reproducible results. The design of the optimal conditions of tissue fixation, embedding, sectioning, dilution of antibodies, and adaptation of Sternberger PAP technique were sane of the parameters taken into account to optimize the results. It is critical that each step of the technique be defined for each particular case.

An experimental study in reducing blood pressure in spontaneously hypertensive rats through extracellular signal-regulated kinase inhibition

2010 ◽  
Vol 34 (8) ◽  
pp. S31-S31
Author(s):  
Li Jing ◽  
Jian‑zhong Zhang ◽  
Jin‑ping Sun ◽  
Xin An ◽  
Feng‑ying Guo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Experimental Study ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Kinase Inhibition ◽  
Spontaneously Hypertensive ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal

An Experimental Study of Some Properties of Stuttered Words

1962 ◽  
Vol 5 (4) ◽  
pp. 387-394 ◽  
Author(s):  
Bruce Quarrington ◽  
Jerome Conway ◽  
Nathan Siegel
Keyword(s):  
Experimental Study

Apraxia May Progress to Neurodegenerative Disease

ASHA Leader ◽  
2016 ◽  
Vol 21 (5) ◽  
pp. 14-14
Keyword(s):  
Neurodegenerative Disease
Sign in / Sign up

Export Citation Format

Share Document