scholarly journals RNAi‐mediated stable silencing of TaCSN5 confers broad‐spectrum resistance to Puccinia striiformis f. sp. tritici

2021 ◽  
Author(s):  
Xingxuan Bai ◽  
Xueling Huang ◽  
Shuxin Tian ◽  
Huan Peng ◽  
Gangming Zhan ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Puccinia Striiformis ◽  
Broad Spectrum Resistance

scholarly journals Xa7, a new executor R gene that confers durable and broad-spectrum resistance to bacterial blight disease in rice

2021 ◽  
pp. 100143
Author(s):  
Xifeng Chen ◽  
Pengcheng Liu ◽  
Le Mei ◽  
Xiaoling He ◽  
Long Chen ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Bacterial Blight ◽  
R Gene ◽  
Broad Spectrum Resistance ◽  
Bacterial Blight Disease ◽  
Blight Disease

scholarly journals Engineering broad-spectrum resistance to cotton leaf curl disease by CRISPR-Cas9 based multiplex editing in plants

2021 ◽  
pp. 1-12
Author(s):  
Muhammad Salman Mubarik ◽  
Xiukang Wang ◽  
Sultan Habibullah Khan ◽  
Aftab Ahmad ◽  
Zulqurnain Khan ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Cotton Leaf ◽  
Broad Spectrum Resistance ◽  
Cotton Leaf Curl Disease ◽  
Leaf Curl Disease ◽  
Leaf Curl

Structure-activity relations and β-lactamase resistance

1980 ◽  
Vol 289 (1036) ◽  
pp. 197-205 ◽  
Keyword(s):  
Broad Spectrum ◽  
Product Inhibition ◽  
Sulphur Atom ◽  
Chemical Modifications ◽  
Gram Negative ◽  
Structure Activity ◽  
Broad Spectrum Resistance ◽  
Structure Activity Relations ◽  
Minor Influence ◽  
A Minor

β-Lactam antibiotics resistant to β-lactamase degradation can be produced by many chemical modifications, but often at the expense of antibacterial activity. Substitution onto several positions in the molecule produces different and often selective resistance; for instance, heavily sterically hindered acyl groups give staphylococcal P-lactamase resistance to penicillins, and resistance to some enzymes from Gram-negative pathogens to both penicillins and cephalosporins. 6-α- or 7-α-substituents respectively confer a broad spectrum of resistance (e.g. cefoxitin), but changes at positions 2 or 3 have only a minor influence on enzyme susceptibility. Changes in the ring condensed with the β-lactam, such as changing ceph-3-em to ceph-2-em may greatly enhance stability. Small improvements can occur when the nuclear sulphur atom is oxidized, but a much better effect is obtained when it is replaced by another atom such as oxygen, as in clavulanic acid. This compound appears to have broad spectrum resistance which is actually due to susceptibility and subsequent product inhibition.

scholarly journals Dissection of broad-spectrum resistance of the Thai rice variety Jao Hom Nin conferred by two resistance genes against rice blast

Rice ◽  
2017 ◽  
Vol 10 (1) ◽  
Author(s):  
Chaivarakun Chaipanya ◽  
Mary Jeanie Telebanco-Yanoria ◽  
Berlaine Quime ◽  
Apinya Longya ◽  
Siripar Korinsak ◽  
...  
Keyword(s):  
Resistance Genes ◽  
Broad Spectrum ◽  
Rice Blast ◽  
Rice Variety ◽  
Broad Spectrum Resistance

A five-transgene cassette confers broad-spectrum resistance to a fungal rust pathogen in wheat

2021 ◽  
Author(s):  
Ming Luo ◽  
Liqiong Xie ◽  
Soma Chakraborty ◽  
Aihua Wang ◽  
Oadi Matny ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Broad Spectrum Resistance ◽  
Rust Pathogen ◽  
Transgene Cassette

scholarly journals Inducible Macrolide Resistance inCorynebacterium jeikeium

2001 ◽  
Vol 45 (7) ◽  
pp. 1982-1989 ◽  
Author(s):  
Adriana E. Rosato ◽  
Bonnie S. Lee ◽  
Kevin A. Nash
Keyword(s):  
Drug Resistance ◽  
Resistance Genes ◽  
Broad Spectrum ◽  
Antimicrobial Agents ◽  
Opportunistic Pathogen ◽  
Macrolide Resistance ◽  
The Other ◽  
Broad Spectrum Resistance ◽  
Neutropenic Patients ◽  
Group 3

ABSTRACT Corynebacterium jeikeium is an opportunistic pathogen primarily of immunocompromised (neutropenic) patients. Broad-spectrum resistance to antimicrobial agents is a common feature of C. jeikeium clinical isolates. We studied the profiles of susceptibility of 20 clinical strains of C. jeikeium to a range of antimicrobial agents. The strains were separated into two groups depending on the susceptibility to erythromycin (ERY), with one group (17 strains) representing resistant organisms (MIC > 128 μg/ml) and the second group (3 strains) representing susceptible organisms (MIC ≤ 0.25 μg/ml). The ERY resistance crossed to other members of the macrolide-lincosamide-streptogramin B (MLSb) group. Furthermore, this resistance was inducible with MLSb agents but not non-MLSb agents. Expression of ERY resistance was linked to the presence of an allele of the class X erm genes,erm(X)cj, with >93% identity to other ermgenes of this class. Our evidence indicates that erm(X)cj is integrated within the chromosome, which contrasts with previous reports for the plasmid-associated erm(X) genes found inC. diphtheriae and C. xerosis. In 40% ofC. jeikeium strains, erm(X)cj is present within the transposon, Tn5432. However, in the remaining strains, the components of Tn5432 (i.e., the erm and transposase genes) have separated within the chromosome. The rearrangement of Tn5432 leads to the possibility that the other drug resistance genes have become included in a new composite transposon bound by the IS1249 elements.

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