scholarly journals Is there an exposure–effect relationship between body mass index and invasive mechanical ventilation, severity, and death in patients with COVID‐19? Evidence from an updated meta‐analysis

2020 ◽  
Vol 21 (11) ◽  
Author(s):  
Menglu Liu ◽  
Chao Deng ◽  
Ping Yuan ◽  
Jianyong Ma ◽  
Peng Yu ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Mechanical Ventilation ◽  
Body Mass ◽  
Meta Analysis ◽  
Invasive Mechanical Ventilation ◽  
Exposure Effect ◽  
Effect Relationship

scholarly journals Dose-Response Relationship Among Body Mass Index, Abdominal Adiposity and Atrial Fibrillation in Patients Undergoing Cardiac Surgery: A Meta-Analysis of 30 Prospective Studies

2020 ◽  
Author(s):  
Menglu Liu ◽  
Kaibo Mei ◽  
Lixia Xie ◽  
Jianyong Ma ◽  
Peng Yu ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Body Mass Index ◽  
Body Mass ◽  
Prospective Studies ◽  
Meta Analysis ◽  
Valve Surgery ◽  
Current Evidence ◽  
Cochrane Library ◽  
Exposure Effect ◽  
Increased Risk

Abstract Background: Whether being overweight increases the risk of postoperative atrial fibrillation (POAF) is unclear, and whether adiposity independently contributes to POAF has not been comprehensively studied. Thus, we conducted a meta-analysis to clarify the strength and shape of the exposure-effect relationship between adiposity and POAF.Methods: The PubMed, Cochrane Library, and EMBASE databases were searched for prospective studies (RCTs, cohort studies, and nest-case control studies) reporting data regarding the relationship between adiposity and the risk of POAF.Results: Thirty publications involving 139,302 patients were included. Analysis of categorical variables showed that obesity (RR: 1.39, P<0.001), but not being underweight (RR: 1.44, P=0.13) or being overweight (RR: 1.03, P=0.48), was associated with an increased risk of POAF. In the exposure-effect analysis, the summary RR for a 5-unit increment in body mass index (BMI) was 1.09 (P<0.001) for the risk of POAF. There was a significant linear relationship between BMI and POAF (Pnonlinearity=0.91); the curve was flat and began to rise steeply at a BMI of approximately 30. Notably, BMI levels below 30 (overweight) were not associated with a higher risk of POAF. In the subgroup analysis of surgery types, the pooled RR values for a BMI increase of 5 for coronary artery bypass graft and valve surgery were 1.21 (P<0.01) and 1.34 (P=0.25), respectively, suggesting that a potential difference in the association exists by surgery type. Additionally, waist obesity was associated with the risk of POAF (RR: 1.55, P<0.001).Conclusion: Based on the current evidence, our findings show that adiposity was independently associated with an increased risk of POAF, while being underweight or overweight might not significantly increase the POAF risk. The magnitude of the effect of obesity on AF in patients undergoing valve surgery might be small, and this finding needs to be further confirmed.

scholarly journals Dose-response relationship among body mass index, abdominal adiposity and atrial fibrillation in patients undergoing cardiac surgery: a meta-analysis of 35 cohorts

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e11855
Author(s):  
Menglu Liu ◽  
Kaibo Mei ◽  
Lixia Xie ◽  
Jianyong Ma ◽  
Peng Yu ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Body Mass Index ◽  
Body Mass ◽  
Meta Analysis ◽  
Current Evidence ◽  
Cochrane Library ◽  
Categorical Variables ◽  
Abdominal Adiposity ◽  
Exposure Effect ◽  
Increased Risk

Background Whether overweight increases the risk of postoperative atrial fibrillation (POAF) is unclear, and whether adiposity independently contributes to POAF has not been comprehensively studied. Thus, we conducted a meta-analysis to clarify the strength and shape of the exposure-effect relationship between adiposity and POAF. Methods The PubMed, Cochrane Library, and EMBASE databases were searched for revelant studies (randomized controlled trials (RCTs), cohort studies, and nest-case control studies) reporting data regarding the relationship between adiposity and the risk of POAF. Results Thirty-five publications involving 33,271 cases/141,442 patients were included. Analysis of categorical variables showed that obesity (RR: 1.39, 95% CI [1.21–1.61]; P < 0.001), but not being underweight (RR: 1.44, 95% CI [0.90–2.30]; P = 0.13) or being overweight (RR: 1.03, 95% CI [0.95–1.11]; P = 0.48) was associated with an increased risk of POAF. In the exposure-effect analysis (BMI) was 1.09 (95% CI [1.05–1.12]; P < 0.001) for the risk of POAF. There was a significant linear relationship between BMI and POAF (Pnonlinearity = 0.44); the curve was flat and began to rise steeply at a BMI of approximately 30. Notably, BMI levels below 30 (overweight) were not associated with a higher risk of POAF. Additionally, waist obesity or visceral adiposity index was associated with the risk of POAF. Conclusion Based on the current evidence, our findings showed that high body mass index or abdominal adiposity was independently associated with an increased risk of POAF, while underweight or overweight might not significantly increase the POAF risk.

scholarly journals Dose-response relationship among body mass index, abdominal adiposity and atrial fibrillation in patients undergoing cardiac surgery: a meta-analysis of 30 prospective studies

2020 ◽  
Author(s):  
Menglu Liu ◽  
Kaibo Mei ◽  
Jianyong Ma ◽  
Peng Yu ◽  
Lixia Xie ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Body Mass Index ◽  
Body Mass ◽  
Prospective Studies ◽  
Meta Analysis ◽  
Valve Surgery ◽  
Current Evidence ◽  
Cochrane Library ◽  
Exposure Effect ◽  
Increased Risk

AbstractBackgroundWhether being overweight increases the risk of postoperative atrial fibrillation (POAF) is unclear, and whether adiposity independently contributes to POAF has not been comprehensively studied. Thus, we conducted a meta-analysis to clarify the strength and shape of the exposure-effect relationship between adiposity and POAF.MethodsThe PubMed, Cochrane Library, and EMBASE databases were searched for prospective studies (RCTs, cohort studies, and nest-case control studies) reporting data regarding the relationship between adiposity and the risk of POAF.ResultsThirty publications involving 139,302 patients were included. Analysis of categorical variables showed that obesity (RR: 1.39, P<0.001), but not being underweight (RR: 1.44, P=0.13) or being overweight (RR: 1.03, P=0.48), was associated with an increased risk of POAF. In the exposure-effect analysis, the summary RR for a 5-unit increment in body mass index (BMI) was 1.09 (P<0.001) for the risk of POAF. There was a significant linear relationship between BMI and POAF (Pnonlinearity=0.91); the curve was flat and began to rise steeply at a BMI of approximately 30. Notably, BMI levels below 30 (overweight) were not associated with a higher risk of POAF. In the subgroup analysis of surgery types, the pooled RR values for a BMI increase of 5 for coronary artery bypass graft and valve surgery were 1.21 (P<0.01) and 1.34 (P=0.25), respectively, suggesting that a potential difference in the association exists by surgery type. Additionally, waist obesity was associated with the risk of POAF (RR: 1.55, P<0.001).ConclusionBased on the current evidence, our findings show that adiposity was independently associated with an increased risk of POAF, while being underweight or overweight might not significantly increase the POAF risk. The magnitude of the effect of obesity on AF in patients undergoing valve surgery might be small, and this finding needs to be further confirmed.

scholarly journals Characterization and Outcomes in Patients with SARS-CoV-2 Infection According to Body Mass Index, Fundación Valle Del Lili, Cali, Colombia 2020-2021

2021 ◽  
Author(s):  
Karen Milena Feriz ◽  
Veline Martínez ◽  
Guillermo Edinson Guzman
Keyword(s):  
Body Mass Index ◽  
Mechanical Ventilation ◽  
Body Mass ◽  
Association Studies ◽  
Invasive Mechanical Ventilation ◽  
Infectious Complications ◽  
University Hospital ◽  
Accelerated Expansion ◽  
Obese Patients ◽  
Prospective Longitudinal

Abstract Introduction: SARS-CoV-2 has undergone an accelerated expansion and was declared a pandemic in 2020. It has been responsible of millions of deaths around the world. Several factors related to severity and mortality have been described, including obesity(1,2). In United States and in Latin America, obesity has grown rapidly (3). In Colombia, 56% of the population is overweight/obese. However, in the region, association studies of SARS-CoV-2 and obesity are scarce. We sought to investigate the characterization and outcomes of patients according to body mass index in a highly complex center in Colombia.Material and Methods: The study was a prospective longitudinal observational descriptive study in patients older than 18 years treated at the Fundación Valle del Lili University Hospital in Cali, Colombia in 2020-2021, with a diagnosis of SARS-CoV-2 infection. Sociodemographic characteristics, medical history, clinical presentation, paraclinical characteristics and outcomes were described. Results: The average age was 48 years, 53% were men, and 66.5% were overweight or obese. Dyspnea (p = 0.003) was the most representative symptom in overweight/obesity. The severity of the disease (p = 0.02), days of stay in the ICU (p = 0.045), overall stay (p = 0.0037), and mechanical ventilation (p = 0) had relationships directly proportional to the increase in BMI (p = 0.022). Obese patients had a higher frequency of sepsis (P 0.003), need for vasopressor (P = 0.001), infectious complications (P = 0.011) and myocarditis (P = 0.03). There was no relationship with thrombotic complications.Conclusion. Overweight and obese patients have more severe symptoms of SARS-CoV-2, infectious complications, and requirements for invasive mechanical ventilation, general hospitalization and ICU stay than the normal weight population.

scholarly journals Effects of Exercise Interventions on Weight, Body Mass Index, Lean Body Mass and Accumulated Visceral Fat in Overweight and Obese Individuals: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2021 ◽  
Vol 18 (5) ◽  
pp. 2635
Author(s):  
Hyun Suk Lee ◽  
Junga Lee
Keyword(s):  
Body Mass Index ◽  
Randomized Controlled Trials ◽  
Lean Body Mass ◽  
Body Mass ◽  
Visceral Fat ◽  
Exercise Intervention ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Exercise Interventions ◽  
Randomized Controlled

(1) Background: Exercise interventions for overweight and obese individuals help reduce accumulated visceral fat, which is an indicator of cardiometabolic risk, but the effectiveness of these interventions is controversial. The purpose of this meta-analysis was to investigate the effectiveness of exercise interventions in overweight and obese individuals in order to reduce weight, body mass index (BMI), and accumulated visceral fat, and increase lean body mass. (2) Methods: Databases were used to select eligible studies for this meta-analysis. Randomized controlled trials with control and experimental groups were included. The degrees of effectiveness of the exercise interventions were computed to assess the benefits on reducing weight, BMI, and accumulated visceral fat, and increasing lean body mass. (3) Results: Sixteen studies were included in this meta-analysis. Participation in exercise interventions reduced weight (d = −0.58 (95% confidence interval (CI), −0.84–−0.31; p < 0.001; k = 9)), BMI (d = −0.50 (95% CI, −0.78–−0.21; p < 0.001; k = 7)), and accumulated visceral fat (d = −1.08 (95% CI, −1.60–−0.57; p < 0.001; k = 5)), but did not significantly increase lean body mass (d = 0.26 (95% CI, −0.11–0.63; p = 0.17; k = 6)). The average exercise intervention for overweight and obese individuals was of moderate to vigorous intensity, 4 times per week, 50 min per session, and 22 weeks duration. (4) Conclusions: Participating in exercise interventions has favorable effects on weight, BMI, and accumulated visceral fat. Further studies considering different modalities, intensities, durations, and measurements of fatness need to be conducted.

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