LncRNA MAFG‐AS1 regulates human periodontal ligament stem cell proliferation and Toll‐like receptor 4 expression

Oral Diseases ◽  
2020 ◽  
Vol 26 (6) ◽  
pp. 1302-1307 ◽  
Author(s):  
Kaixin Wangzhou ◽  
Lei Gong ◽  
Cheng Liu ◽  
Yi Tan ◽  
Jingxin Chen ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Periodontal Ligament ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Stem Cell Proliferation ◽  
Periodontal Ligament Stem Cell

scholarly journals Hyaluronic acid promotes Lgr5+ stem cell proliferation and crypt fission through TLR4 and PGE2 transactivation of EGFR

2020 ◽  
Vol 319 (1) ◽  
pp. G63-G73
Author(s):  
Terrence E. Riehl ◽  
David Alvarado ◽  
Xueping Ee ◽  
Matthew A. Ciorba ◽  
William F. Stenson
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Hyaluronic Acid ◽  
Growth Factor Receptor ◽  
Normal Growth ◽  
Receptor Activation ◽  
Toll Like Receptor ◽  
Newborn Mice ◽  
Stem Cell Proliferation ◽  
Crypt Fission

This study, in newborn mice, describes a novel molecular pathway regulating Lgr5+ epithelial stem cell proliferation and normal intestinal elongation, as assessed by crypt fission. In this pathway, endogenous extracellular hyaluronic acid binds to Toll-like receptor 4 on pericryptal macrophages releasing PGE2 which binds to epidermal growth factor receptor on Lgr5+ stem cells resulting in proliferation. Lgr5+ stem cell proliferation leads to crypt fission and intestinal elongation. The demonstration that normal growth requires microbial-independent Toll-like receptor activation is novel.

scholarly journals Cigarette smoking hinders human periodontal ligament-derived stem cell proliferation, migration and differentiation potentials

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Tsz Kin Ng ◽  
Li Huang ◽  
Di Cao ◽  
Yolanda Wong-Ying Yip ◽  
Wai Ming Tsang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Cigarette Smoking ◽  
Periodontal Ligament ◽  
Stem Cell Proliferation
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