scholarly journals How does early symptom change predict subsequent course of depressive symptoms during psychotherapy?

2021 ◽  
Author(s):  
Kristina Fuhr ◽  
Dustin Werle ◽  
Anil Batra
Keyword(s):  
Depressive Symptoms ◽  
Symptom Change ◽  
Early Symptom

Association between depression and hypertension using classic and revised blood pressure thresholds

2020 ◽  
Vol 37 (5) ◽  
pp. 616-622
Author(s):  
Dustin S DeMoss ◽  
Kari J Teigen ◽  
Cynthia A Claassen ◽  
Mandy J Fisk ◽  
Somer E Blair ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Depressive Symptoms ◽  
Depressive Symptom ◽  
Robust Regression ◽  
Heart Association ◽  
P Value ◽  
Symptom Change ◽  
Primary Care Population ◽  
Treatment Of Depression ◽  
Guideline Group

Abstract Background In a primary care population, the relationship between treatment of depression and hypertension (HTN) under the recently revised American College of Cardiology and American Heart Association HTN thresholds for diagnosing HTN is unknown. Objective To compare the association between changes in severity of co-occurring depression and HTN over time using the newly revised versus previous HTN guidelines. Methods In this retrospective cohort study, outpatients ≥18 years (n = 3018) with clinically significant depressive symptoms and elevated blood pressure at baseline were divided into a ‘revised’ guideline group (baseline blood pressure ≥130/80 mmHg), a ‘classic’ guideline group (≥140/90 mmHg) and a ‘revised-minus-classic’ group (≥130/80 and <140/90 mmHg). Depressive symptom change was assessed using the Patient Health Questionnaire-9 (PHQ-9). Correlations between changes in PHQ-9 scores and HTN levels by group over a 6- to 18-month observation period were assessed using robust regression analysis. Results There were demographic and clinical differences between groups. A total of 41% of study subjects (1252/3018) had a visit during the follow-up period where additional PHQ-9 and HTN results were available. Depressive symptom change was unrelated to change in blood pressure in the revised and revised-minus-classic groups. The classic HTN group demonstrated a clinically insignificant change in systolic blood pressure for each unit change in PHQ-9 score (β = 0.23, P-value =0.02). Conclusions Although a statistically significant association between reduced HTN levels and improvement in depressive symptoms was demonstrated under classic HTN guidelines, there was no clinically meaningful association between treatment of depression and improved HTN levels under either guideline.

Providing information about the effectiveness of treatment options to depressed people in the community: a randomized controlled trial of effects on mental health literacy, help-seeking and symptoms

2003 ◽  
Vol 33 (6) ◽  
pp. 1071-1079 ◽  
Author(s):  
A. F. JORM ◽  
K. M. GRIFFITHS ◽  
H. CHRISTENSEN ◽  
A. E. KORTEN ◽  
R. A. PARSLOW ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Depressive Symptoms ◽  
Help Seeking ◽  
Mental Health Literacy ◽  
Controlled Trial ◽  
Treatment Options ◽  
Evidence Based ◽  
Symptom Change ◽  
Professional Help ◽  
Randomized Controlled

Background. Many people who are depressed do not receive any professional help and their beliefs about the helpfulness of treatment do not always correspond with those of health professionals. To facilitate choices about treatment, the present study examined the effects of providing depressed people in the community with evidence on whether various treatment options work.Method. A randomized controlled trial was carried out with 1094 persons selected at random from the community who screened positive for depressive symptoms and agreed to participate. Participants were mailed either an evidence-based consumer guide to treatments for depression or, as a control, a general brochure on depression. Outcomes were the rated usefulness of the information provided, changes in attitudes to depression treatments, actions taken to reduce depression, and changes in depressive symptoms, anxiety symptoms and disability.Results. Participants rated the evidence-based consumer guide as more useful than the control brochure. Attitudes to some treatments changed. Improvements in symptoms and disability did not differ significantly between interventions.Conclusion. Providing people who are depressed with evidence on which treatments work produces some changes in attitudes and behaviour. However, this intervention may need to be enhanced if it is to produce symptom change.

scholarly journals Brief Report: Preliminary evidence that co-rumination fosters adolescents’ depression risk by increasing rumination

2017 ◽  
Author(s):  
Lindsey B Stone ◽  
Brandon Gibb
Keyword(s):  
High School ◽  
Depressive Symptoms ◽  
Depressive Symptom ◽  
Direct Effect ◽  
Preliminary Evidence ◽  
Interpersonal Process ◽  
Symptom Change ◽  
High School Freshmen ◽  
Depression Risk ◽  
Proposed Model

Mounting research shows that the tendency to co-ruminate with peers regarding ongoing problems increases adolescents’ depression risk; however, the means by which this interpersonal process fosters risk has not been identified. This said, theorists have proposed that co-rumination increases depression risk, in part, by increasing one’s tendency to ruminate when alone. We tested this hypothesis in a study of 201 high-school freshmen who completed two assessments, six months apart. Supporting the proposed model, co-rumination predicted prospective increases in rumination and rumination predicted increases in depressive symptoms. The direct effect of co-rumination on depressive symptom change was not significant. Results indicate that co-rumination with friends may serve to increase rumination, which in turn increases depression risk.

scholarly journals The Potential Influence of Group Membership on Outcomes in Indicated Cognitive-Behavioral Adolescent Depression Prevention

2020 ◽  
Vol 17 (18) ◽  
pp. 6553
Author(s):  
Paul Rohde ◽  
Frédéric N. Brière ◽  
Eric Stice
Keyword(s):  
Depressive Symptoms ◽  
Depressive Symptom ◽  
Adolescent Depression ◽  
Group Membership ◽  
Cognitive Behavioral ◽  
Group Level ◽  
Symptom Change ◽  
Post Intervention ◽  
Depression Prevention

Background: Adolescent depression prevention programs are typically delivered in groups in which adolescents share a common setting and interventionist, but the influence of the group is usually ignored or statistically controlled. We tested whether the primary outcomes of reductions in depressive symptoms and future onset of major depressive disorder (MDD) varied as a function of group membership. Methods: Data were available from two randomized trials in which 220 adolescents received the Blues Program indicated prevention intervention in 36 separate groups; participants were assessed at baseline, post intervention, and at 6-, 12-, and 24-month follow-ups. Results: Ten percent of participants had developed MDD 2 years post intervention. Group-level effects for MDD onset over follow-up were nonsignificant (accounted for <1% of variance; ICC = 0.004, ns). Group-level effects for depressive symptom change across the follow-up period were also nonsignificant (ICC = 0.001, ns) but group effects accounted for 16% of depressive symptom change immediately post intervention (ICC = 0.159, p < 0.05). Group-level clustering of posttest depressive symptoms was not associated with size of group or gender composition. Conclusions: Membership in specific adolescent cognitive-behavioral depression prevention groups may have an impact in terms of immediate symptom reduction but does not appear to have significant prevention effects in terms of long-term symptom change or MDD onset.

Early symptom change and prediction of subsequent remission with olanzapine augmentation in divalproex-resistant bipolar mixed episodes

2011 ◽  
Vol 45 (2) ◽  
pp. 169-173 ◽  
Author(s):  
John P. Houston ◽  
Terence A. Ketter ◽  
Michael Case ◽  
Charles Bowden ◽  
Elisabeth K. Degenhardt ◽  
...  
Keyword(s):  
Symptom Change ◽  
Early Symptom

scholarly journals Left prefrontal impact links subthalamic stimulation with depressive symptoms

2019 ◽  
Author(s):  
Friederike Irmen ◽  
Andreas Horn ◽  
Philip Mosley ◽  
Alistair Perry ◽  
Jan Niklas Petry-Schmelzer ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Depressive Symptom ◽  
Structural Connectivity ◽  
Electrode Placement ◽  
Validation Dataset ◽  
Symptom Change ◽  
Test Set ◽  
Before And After ◽  
The Impact ◽  
Stn Dbs

AbstractObjectiveSubthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s Disease (PD) not only stimulates focal target structures but also affects distributed brain networks. The impact this network modulation has on non-motor DBS effects is not well characterized. By focusing on the affective domain, we systematically investigate the impact of electrode placement and associated structural connectivity on changes in depressive symptoms following STN-DBS which have been reported to improve, worsen or remain unchanged.MethodsDepressive symptoms before and after STN-DBS surgery were documented in 116 PD patients from three DBS centers (Berlin, Queensland, Cologne). Based on individual electrode reconstructions, the volumes of tissue activated (VTA) were estimated and combined with normative connectome data to identify structural connections passing through VTAs. Berlin and Queensland cohorts formed a training and cross-validation dataset used to identify structural connectivity explaining change in depressive symptoms. The Cologne data served as test-set for which depressive symptom change was predicted.ResultsStructural connectivity was linked to depressive symptom change under STN-DBS. An optimal connectivity map trained on the Berlin cohort could predict changes in depressive symptoms in Queensland patients and vice versa. Furthermore, the joint training-set map predicted changes in depressive symptoms in the independent test-set. Worsening of depressive symptoms was associated with left prefrontal connectivity.InterpretationFibers linking the STN electrode with left prefrontal areas predicted worsening of depressive symptoms. Our results suggest that for the left STN-DBS lead, placement impacting fibers to left prefrontal areas should be avoided to maximize improvement of depressive symptoms.

scholarly journals Investigating Sequential and Simultaneous Changes in Trajectories of Cognitive Decline and Depressive Symptoms

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 75-75
Author(s):  
Matthias Klee ◽  
Anja Leist
Keyword(s):  
Depressive Symptoms ◽  
Cognitive Decline ◽  
Employment Status ◽  
Depression Scale ◽  
Memory Recall ◽  
Delayed Recall ◽  
Early Symptom ◽  
Co Morbidity ◽  
Logistic Regressions

Abstract Background. The role of depression as risk factor or early symptom of cognitive decline and dementia is still debated. Exploiting longitudinal trajectories of memory recall in a large European sample, we sought to better understand the nature of simultaneous versus sequential changes in depressive symptoms alongside memory recall at older ages. Method. A total of 4,865 respondents to the SHARE survey, mean age at t1 61.5 years (SD = 7.53), completed the EURO-D depression scale and a delayed recall task across six waves spanning ~13 years. We applied k-means clustering to distinguish trajectories of depressive symptoms and delayed recall. Clusters indicating depressive and recall trajectories were included in logistic regressions to assess likelihood of parallel versus sequential change, controlling for age, gender, employment status and education. Results. Analyses revealed six distinct trajectories each for depressive symptoms and delayed recall. Visual inspections indicated that only declining recall trajectories showed increases in depressive symptoms, occurring simultaneously rather than sequentially. Using grouped declining recall trajectories as outcome, the low-increasing depressive symptoms trajectory was associated with cognitive decline (OR = 1.52 [1.11, 2.06]), whereas the stable-high depressive symptoms trajectory was associated with cognitive decline in respondents aged 60-69 years (OR = 1.78 [1.01, 3.16]). Discussion. Distinguishing trajectories in depression and recall incorporates longitudinal information able to further elucidate relationships between depression and cognition. While the findings suggest depression as a co-morbidity, attention needs to be given to a comparatively small high-stable depressive symptoms trajectory group with elevated risk of cognitive decline in their 60s.

Covariation of depressive symptoms over time

1984 ◽  
Vol 14 (2) ◽  
pp. 451-455 ◽  
Author(s):  
George A. Hibbert ◽  
John D. Teasdale ◽  
Peter Spencer
Keyword(s):  
Factor Analysis ◽  
Depressive Symptoms ◽  
Symptom Change ◽  
Total Change ◽  
Change Scores ◽  
Low Mood ◽  
Symptom Scores ◽  
Patient Factor ◽  
Over Time

SynopsisThe covariation over time of depressive symptoms was studied by repeated ratings of the symptoms of individual depressed in-patients. Both within-patient factor analysis of symptom scores and correlation of symptom change scores to total change scores suggested that, while the symptoms of reduced interest and pleasure covaried closely with ratings of observed and reported low mood, the more ‘biological’ symptoms of sleep and appetite disturbance showed little covariation. The implications for the study of depression are discussed.

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