scholarly journals Genotype‐dependent contribution of CBF transcription factors to long‐term acclimation to high light and cool temperature

2021 ◽  
Author(s):  
Christopher R. Baker ◽  
Jared J. Stewart ◽  
Cynthia L. Amstutz ◽  
Lindsey G. Ching ◽  
Jeffrey D. Johnson ◽  
...  
Keyword(s):  
Transcription Factors ◽  
High Light ◽  
Cool Temperature ◽  
Cbf Transcription Factors

scholarly journals Role of CBF transcription factors during long-term acclimation to high light and low temperature in two ecotypes of a winter annual

2020 ◽  
Author(s):  
christopher baker ◽  
Jared Stewart ◽  
Cynthia Amstutz ◽  
Jeffrey Johnson ◽  
Lindsey Ching ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Low Temperature ◽  
High Light ◽  
Winter Annual ◽  
Cbf Transcription Factors

scholarly journals Role of CBF transcription factors during long-term acclimation to high light and low temperature in two ecotypes of Arabidopsis thaliana

2021 ◽  
Author(s):  
christopher baker ◽  
Jared Stewart ◽  
Cynthia Amstutz ◽  
Jeffrey Johnson ◽  
Lindsey Ching ◽  
...  
Keyword(s):  
Arabidopsis Thaliana ◽  
Transcription Factors ◽  
Freezing Tolerance ◽  
Transcriptional Control ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Light Level ◽  
High Light ◽  
Cool Temperature

When grown under cool temperature, winter annuals upregulate photosynthetic capacity as well as freezing tolerance. Here, the role of three cold-induced C-repeat-Binding Factor (CBF1–3) transcription factors in photosynthetic upregulation and freezing tolerance was examined in two Arabidopsis thaliana ecotypes originating from Italy (IT) or Sweden (SW), and their corresponding CBF1–3-deficient mutant lines it:cbf123 and sw:cbf123. Photosynthetic, morphological, and freezing-tolerance phenotypes as well as gene expression profiles were characterized in plants grown from seedling stage under different combinations of light level and temperature. Under high light and cool growth temperature (HLC), a greater role of CBF1–3 in IT versus SW was evident from both phenotypic and transcriptomic data, especially with respect to photosynthetic upregulation and freezing tolerance of whole plants. Overall, features of SW were consistent with a different approach to HLC acclimation than seen in IT, and an ability of SW to reach the new homeostasis through involvement of transcriptional controls other than CBF1–3. These results provide tools and direction for further mechanistic analysis of the transcriptional control of approaches to cold acclimation suitable for either persistence through brief cold spells or for maximization of productivity in environments with continuous low temperatures.

scholarly journals Regulation of the p75 neurotrophin receptor attenuates neuroinflammation and stimulates hippocampal neurogenesis in experimental Streptococcus pneumoniae meningitis

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Dandan Zhang ◽  
Shengnan Zhao ◽  
Zhijie Zhang ◽  
Danfeng Xu ◽  
Di Lian ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Streptococcus Pneumoniae ◽  
Proinflammatory Cytokines ◽  
Neuronal Apoptosis ◽  
Hippocampal Neurogenesis ◽  
Clinical Severity ◽  
Neurotrophin Receptor ◽  
Apoptosis And Necrosis

Abstract Background Streptococcus pneumoniae meningitis is a destructive central nervous system (CNS) infection with acute and long-term neurological disorders. Previous studies suggest that p75NTR signaling influences cell survival, apoptosis, and proliferation in brain-injured conditions. However, the role of p75NTR signaling in regulating pneumococcal meningitis (PM)-induced neuroinflammation and altered neurogenesis remains largely to be elucidated. Methods p75NTR signaling activation in the pathological process of PM was assessed. During acute PM, a small-molecule p75NTR modulator LM11A-31 or vehicle was intranasally administered for 3 days prior to S. pneumoniae exposure. At 24 h post-infection, clinical severity, histopathology, astrocytes/microglia activation, neuronal apoptosis and necrosis, inflammation-related transcription factors and proinflammatory cytokines/mediators were evaluated. Additionally, p75NTR was knocked down by the adenovirus-mediated short-hairpin RNA (shRNA) to ascertain the role of p75NTR in PM. During long-term PM, the intranasal administration of LM11A-31 or vehicle was continued for 7 days after successfully establishing the PM model. Dynamic changes in inflammation and hippocampal neurogenesis were assessed. Results Our results revealed that both 24 h (acute) and 7, 14, 28 day (long-term) groups of infected rats showed increased p75NTR expression in the brain. During acute PM, modulation of p75NTR through pretreatment of PM model with LM11A-31 significantly alleviated S. pneumoniae-induced clinical severity, histopathological injury and the activation of astrocytes and microglia. LM11A-31 pretreatment also significantly ameliorated neuronal apoptosis and necrosis. Moreover, we found that blocking p75NTR with LM11A-31 decreased the expression of inflammation-related transcription factors (NF-κBp65, C/EBPβ) and proinflammatory cytokines/mediators (IL-1β, TNF-α, IL-6 and iNOS). Furthermore, p75NTR knockdown induced significant changes in histopathology and inflammation-related transcription factors expression. Importantly, long-term LM11A-31 treatment accelerated the resolution of PM-induced inflammation and significantly improved hippocampal neurogenesis. Conclusion Our findings suggest that the p75NTR signaling plays an essential role in the pathogenesis of PM. Targeting p75NTR has beneficial effects on PM rats by alleviating neuroinflammation and promoting hippocampal neurogenesis. Thus, the p75NTR signaling may be a potential therapeutic target to improve the outcome of PM.

scholarly journals Regulation of the p75 Neurotrophin Receptor Attenuates Neuroinflammation and Stimulates Hippocampal Neurogenesis in Experimental Streptococcus Pneumoniae Meningitis

2021 ◽  
Author(s):  
Dandan Zhang ◽  
Shengnan Zhao ◽  
Zhijie Zhang ◽  
Danfeng Xu ◽  
Di Lian ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Streptococcus Pneumoniae ◽  
Cell Apoptosis ◽  
Neuronal Cell ◽  
Hippocampal Neurogenesis ◽  
Clinical Severity ◽  
Neurotrophin Receptor ◽  
Double Labeling

Abstract Background: Streptococcus pneumoniae meningitis is a destructive central nervous system (CNS) infection with acute and long-term neurological disorders. Compelling evidence provided by previous studies suggests that p75NTR signaling influences cell survival, apoptosis, and proliferation in brain-injured conditions. However, the role of p75NTR signaling in regulating pneumococcal meningitis (PM)-induced neuroinflammation and altered neurogenesis remains largely to be elucidated.Methods: p75NTR signaling activation in the pathological process of PM was assessed. During acute PM, a small-molecule p75NTR modulator LM11A-31 or vehicle was intranasally administered for 3 days prior to S.pneumoniae exposure. At 24h post-infection, clinical severity, histopathology, astrocytes/microglia activation, neuronal cell apoptosis and death, inflammation-related transcription factors and inflammatory factors were evaluated. Additionally, p75NTR was knocked down by the adenovirus-mediated short-hairpin RNA (shRNA) to ascertain the role of p75NTR in PM. During long-term PM, the intranasal administration of LM11A-31 or vehicle was continued for 7 days after successfully establishing the PM model. Hippocampal neurogenesis was evaluated by double-labeling immunofluorescence with EdU, DCX and NeuN. Results: Our results revealed that both 24h (acute) and 7,14,28day (long-term) groups of infected rats demonstrated increased p75NTR expression in the brain. During acute PM, modulation of p75NTR through pretreatment of PM model with LM11A-31 significantly alleviated S.pneumoniae-induced clinical severity, histopathological injury and the activation of astrocytes and microglia. LM11A-31 pretreatment also significantly ameliorated neuronal cell apoptosis and death. Moreover, we found that blocking p75NTR with LM11A-31 decreased the expression of inflammation-related transcription factors (NF-κBp65, C/EBPβ) and proinflammatory cytokine (IL-1β, TNF-α, IL-6 and iNOS) in the cortex and hippocampus. Furthermore, p75NTR knockdown induced significant changes in histopathology and inflammation-related transcription factors expression. Importantly, combined LM11A-31 adjuvant therapy significantly improved hippocampal neurogenesis.Conclusion: Our findings suggest that the p75NTR signaling plays an essential role in the pathogenesis of PM. Targeting p75NTR has benefit effects on PM rats by alleviating neuroinflammation and promoting hippocampal neurogenesis. Thus, the p75NTR signaling may be a potential therapeutic target to improve the outcome of PM.

scholarly journals FOXO Transcriptional Factors and Long-Term Living

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Ghulam Murtaza ◽  
Abida Kalsoom Khan ◽  
Rehana Rashid ◽  
Saiqa Muneer ◽  
Syed Muhammad Farid Hasan ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Healthy Aging ◽  
Growth Stress ◽  
Human Longevity ◽  
Growth Factor Signaling ◽  
Forkhead Box ◽  
Foxo Transcription Factors ◽  
Genetic And Environmental Factors

Several pathologies such as neurodegeneration and cancer are associated with aging, which is affected by many genetic and environmental factors. Healthy aging conceives human longevity, possibly due to carrying the defensive genes. For instance, FOXO (forkhead box O) genes determine human longevity. FOXO transcription factors are involved in the regulation of longevity phenomenon via insulin and insulin-like growth factor signaling. Only one FOXO gene (FOXO DAF-16) exists in invertebrates, while four FOXO genes, that is, FOXO1, FOXO3, FOXO4, and FOXO6 are found in mammals. These four transcription factors are involved in the multiple cellular pathways, which regulate growth, stress resistance, metabolism, cellular differentiation, and apoptosis in mammals. However, the accurate mode of longevity by FOXO factors is unclear until now. This article describes briefly the existing knowledge that is related to the role of FOXO factors in human longevity.

The major photoprotective role of anthocyanins in leaves of Arabidopsis thaliana under long-term high light treatment: antioxidant or light attenuator?

2020 ◽  
Author(s):  
Xiao-Ting Zheng ◽  
Zheng-Chao Yu ◽  
Jun-Wei Tang ◽  
Min-Ling Cai ◽  
Yi-Lin Chen ◽  
...  
Keyword(s):  
Arabidopsis Thaliana ◽  
Light Treatment ◽  
High Light ◽  
High Light Treatment

Primary Brain Tumors Differ in Their Expression of Octamer Deoxyribonucleic Acid-binding Transcription Factors from Long-Term Cultured Glioma Cell Lines

Neurosurgery ◽  
1994 ◽  
Vol 34 (1) ◽  
pp. 129-135 ◽  
Author(s):  
Edgar Schreiber ◽  
Randall E. Merchant ◽  
Otmar D. Wiestler ◽  
Adriano Fontana
Keyword(s):  
Transcription Factors ◽  
Brain Tumors ◽  
Cell Lines ◽  
Glioma Cell ◽  
Deoxyribonucleic Acid ◽  
Primary Brain Tumors ◽  
Glioma Cell Lines

Enhancement of Cytochrome b 559 Indicates Its Possible Involvement in Long-Term High Light Stress Tolerance in Intertidal Macroalgae

2015 ◽  
Vol 33 (6) ◽  
pp. 1918-1927 ◽  
Author(s):  
Wenhui Gu ◽  
Li Huan ◽  
Ruixue Yu ◽  
Guanghua Pan ◽  
Guangce Wang
Keyword(s):  
Stress Tolerance ◽  
Cytochrome B ◽  
Light Stress ◽  
High Light ◽  
High Light Stress

scholarly journals Thresholds for synaptic activation of transcription factors in hippocampus: correlation with long-term enhancement

1993 ◽  
Vol 13 (11) ◽  
pp. 4776-4786 ◽  
Author(s):  
PF Worley ◽  
RV Bhat ◽  
JM Baraban ◽  
CA Erickson ◽  
BL McNaughton ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Synaptic Activation ◽  
Activation Of Transcription

scholarly journals Equine arteritis virus long-term persistence is orchestrated by CD8+ T lymphocyte transcription factors, inhibitory receptors, and the CXCL16/CXCR6 axis

2019 ◽  
Vol 15 (7) ◽  
pp. e1007950 ◽  
Author(s):  
Mariano Carossino ◽  
Pouya Dini ◽  
Theodore S. Kalbfleisch ◽  
Alan T. Loynachan ◽  
Igor F. Canisso ◽  
...  
Keyword(s):  
Transcription Factors ◽  
T Lymphocyte ◽  
Equine Arteritis Virus ◽  
Inhibitory Receptors ◽  
Cd8 T Lymphocyte
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