Cytomegalovirus‐related sepsis‐like syndrome in very premature infants in Japan

2021 ◽  
Author(s):  
Fumihiko Namba ◽  
Ryota Nakagawa ◽  
Mitsuhiro Haga ◽  
Seiji Yoshimoto ◽  
Yutaro Tomobe ◽  
...  
Keyword(s):  
Premature Infants ◽  
Very Premature Infants

Maturation of the rectoanal inhibitory reflex in very premature infants

2003 ◽  
Vol 143 (5) ◽  
pp. 630-633 ◽  
Author(s):  
Fleur de Lorijn ◽  
T.I Omari ◽  
J.H Kok ◽  
J.A.J.M Taminiau ◽  
M.A Benninga
Keyword(s):  
Premature Infants ◽  
Rectoanal Inhibitory Reflex ◽  
Very Premature Infants ◽  
Inhibitory Reflex

Can Mozart Improve Weight Gain and Development of Feeding Skills in Premature Infants? A Randomized Trial

2021 ◽  
Author(s):  
Margaret A. Lafferty ◽  
Amy Mackley ◽  
Pam Green ◽  
Deborah Ottenthal ◽  
Robert Locke ◽  
...  
Keyword(s):  
Birth Weight ◽  
Premature Infants ◽  
Randomized Study ◽  
Oral Feeding ◽  
Secondary Outcome ◽  
Piano Sonata ◽  
Speech Language Pathologist ◽  
Physiologic Effect ◽  
Feeding Skills ◽  
Very Premature Infants

Objective The study aimed to assess in a prospective randomized study the effect of Mozart's music on time to regain birth weight (BW) and development of oral feeding skills in babies born between 280/7 and 316/7 weeks of gestation. Study Design Healthy premature infants born between 280/7 and 316/7 completed weeks of gestation were randomized within 3 days of birth to either music or no music exposure. Infants in the music group were exposed to Mozart's double piano sonata twice per day for 14 days. The primary outcome was time to regain birth weight. The secondary outcome was development of oral feeding skills as evaluated by a speech/language pathologist blinded to the intervention. We hypothesized that exposure to Mozart's double piano sonata would decrease time to regain BW and improve feeding skills. A total of 32 newborns were needed to detect a 3-day difference in time to regain BW. Results Forty infants were enrolled and randomized. There were no significant differences between the two groups regarding the time to regain BW (p = 0.181) and the time to achievement of full oral feeds (p = 0.809). Conclusion Exposure to Mozart's double piano sonata for 14 days after birth did not significantly improve time to regain BW or time to achieve full oral feedings in very premature infants. It is possible that Mozart's music has no effect or that the duration of music exposure was not sufficient to have a physiologic effect on growth and oral feeding skills. Key Points

THE SHIFT FROM UNDER- TO OVER-TREATMENT

PEDIATRICS ◽  
1994 ◽  
Vol 93 (1) ◽  
pp. A52-A52
Keyword(s):  
Survival Rate ◽  
Premature Infants ◽  
Handicapped Children ◽  
Very Premature Infants

...from therapeutic nihilism based on the prevailing belief that any measures taken to increase the survival rate [of very premature infants] would result in increasing numbers of handicapped children who would be a burden to their families, to overzealous intervention which suggests it is mothers not infants whose interests should be ignored.

Consequences of Delayed Surgical Closure of Patent Ductus Arteriosus in Very Premature Infants

2006 ◽  
Vol 81 (1) ◽  
pp. 231-234 ◽  
Author(s):  
Sophie Jaillard ◽  
Benoît Larrue ◽  
Thameur Rakza ◽  
Eric Magnenant ◽  
Henri Warembourg ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
Surgical Closure ◽  
Very Premature Infants ◽  
Patent Ductus

Population Pharmacokinetic Modeling in Very Premature Infants Receiving Midazolam during Mechanical Ventilation 

1999 ◽  
Vol 90 (2) ◽  
pp. 451-457 ◽  
Author(s):  
Toong C. Lee ◽  
Bruce G. Charles ◽  
Glen J. Harte ◽  
Peter H. Gray ◽  
Peter A. Steer ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Population Pharmacokinetics ◽  
Premature Infants ◽  
Coefficient Of Variation ◽  
Population Analysis ◽  
Volume Of Distribution ◽  
Continuous Treatment ◽  
Peripheral Compartment ◽  
Population Pharmacokinetic ◽  
Very Premature Infants

Background Midazolam is used widely as a sedative to facilitate mechanical ventilation. This prospective study investigated the population pharmacokinetics of midazolam in very premature infants. Methods Midazolam (100 microg/kg) was administered as a rapid intravenous bolus dose every 4-6 h to 60 very premature neonates with a mean (range) gestational age of 27 weeks (24-31 weeks), a birth weight of 965 g (523-1,470 g), and an age of 4.5 days (2-15 days). A median (range) of four (one to four) blood samples, 0.2 ml each, were drawn at random times after the first dose or during continuous treatment, and concentrations of midazolam in serum were assayed by high-performance liquid chromatography. A population analysis was conducted using a two-compartment pharmacokinetic model using the NONMEM program. Results Average parameter values (interpatient percent coefficient of variation) for infants with birth weights 1,000 g or less were total systemic clearance (Cl(T)) = 0.783 ml/min (83%), intercompartmental clearance (Cl(Q)) = 6.53 ml/min (116%), volume of distribution of the central compartment (V1) = 473 ml (70%), and volume of distribution of the peripheral compartment (V2) = 513 ml (146%). For infants with birth weights more than 1,000 g they were as follows: Cl(T) = 1.24 ml/min (78%), Cl(Q) = 9.82 ml/min (98%), V1 = 823 ml (43%), and V2 = 1,040 ml (193%). The intrapatient variability (percent coefficient of variation) in the data was 4.5% at the mean concentration midazolam in serum of 121 ng/mL. Conclusions Serum concentration-time data were used in modeling the population pharmacokinetics of midazolam in very premature, ventilated neonates. Clearance of midazolam was markedly decreased compared with previous data from term infants and older patients. Infants weighing less than 1,000 g at birth had significantly lower clearance than those weighing more than 1,000 g.

Variation in Enteral Feeding Practices and Growth Outcomes among Very Premature Infants: A Report from the New York State Perinatal Quality Collaborative

2015 ◽  
Vol 33 (01) ◽  
pp. 009-019 ◽  
Author(s):  
Eileen Shields ◽  
Deborah Campbell ◽  
Adriann Combs ◽  
Michael Horgan ◽  
Edmund La Gamma ◽  
...  
Keyword(s):  
New York ◽  
Premature Infants ◽  
Enteral Feeding ◽  
New York State ◽  
Feeding Practices ◽  
York State ◽  
Growth Outcomes ◽  
Very Premature Infants

Drug Utilization in Very Premature Infants in Neonatal Intensive Care Units

1991 ◽  
Vol 17 (3-4) ◽  
pp. 167-171 ◽  
Author(s):  
L. Gortner ◽  
U. Bernsau ◽  
M. Brand ◽  
H.H. Hellwege ◽  
G. Hieronimie ◽  
...  
Keyword(s):  
Intensive Care ◽  
Intensive Care Units ◽  
Drug Utilization ◽  
Premature Infants ◽  
Neonatal Intensive Care ◽  
Neonatal Intensive Care Units ◽  
Very Premature Infants
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