scholarly journals A Risk Analysis Approach to Prioritizing Epidemics: Ebola Virus Disease in West Africa as a Case Study

Risk Analysis ◽  
2017 ◽  
Vol 38 (3) ◽  
pp. 429-441 ◽  
Author(s):  
Whenayon Simeon Ajisegiri ◽  
Abrar Ahmad Chughtai ◽  
C. Raina MacIntyre
Keyword(s):  
Risk Analysis ◽  
West Africa ◽  
Ebola Virus ◽  
Virus Disease ◽  
Ebola Virus Disease ◽  
Analysis Approach

scholarly journals Characterisation of the T-cell response to Ebola virus glycoprotein amongst survivors of the 2013–16 West Africa epidemic

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
T. R. W. Tipton ◽  
Y. Hall ◽  
J. A. Bore ◽  
A. White ◽  
L. S. Sibley ◽  
...  
Keyword(s):  
T Cell ◽  
West Africa ◽  
Cell Response ◽  
Ebola Virus ◽  
Medical Condition ◽  
Virus Disease ◽  
T Cell Response ◽  
Ebola Virus Disease ◽  
Cell Phenotype ◽  
T Cell Epitopes

AbstractZaireebolavirus (EBOV) is a highly pathogenic filovirus which can result in Ebola virus disease (EVD); a serious medical condition that presents as flu like symptoms but then often leads to more serious or fatal outcomes. The 2013–16 West Africa epidemic saw an unparalleled number of cases. Here we show characterisation and identification of T cell epitopes in surviving patients from Guinea to the EBOV glycoprotein. We perform interferon gamma (IFNγ) ELISpot using a glycoprotein peptide library to identify T cell epitopes and determine the CD4+ or CD8+ T cell component response. Additionally, we generate data on the T cell phenotype and measure polyfunctional cytokine secretion by these antigen specific cells. We show candidate peptides able to elicit a T cell response in EBOV survivors and provide inferred human leukocyte antigen (HLA) allele restriction. This data informs on the long-term T cell response to Ebola virus disease and highlights potentially important immunodominant peptides.

scholarly journals Comparative phylogeography of African fruit bats (Chiroptera, Pteropodidae) provide new insights into the outbreak of Ebola virus disease in West Africa, 2014–2016

2016 ◽  
Vol 339 (11-12) ◽  
pp. 517-528 ◽  
Author(s):  
Alexandre Hassanin ◽  
Nicolas Nesi ◽  
Julie Marin ◽  
Blaise Kadjo ◽  
Xavier Pourrut ◽  
...  
Keyword(s):  
West Africa ◽  
Ebola Virus ◽  
Virus Disease ◽  
Ebola Virus Disease ◽  
Fruit Bats ◽  
Comparative Phylogeography

scholarly journals Seroprevalence of Ebola virus infection in Bombali District, Sierra Leone

2017 ◽  
Author(s):  
Nadege Goumkwa Mafopa ◽  
Gianluca Russo ◽  
Raoul Emeric Guetiya Wadoum ◽  
Emmanuel Iwerima ◽  
Vincent Batwala ◽  
...  
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
West Africa ◽  
Sierra Leone ◽  
Ebola Virus ◽  
Virus Disease ◽  
Asymptomatic Infection ◽  
Ebola Virus Disease ◽  
Efficient Immune Response ◽  
Ebola Virus Infection

A serosurvey of anti-Ebola Zaire virus nucleoprotein IgG prevalence was carried out among Ebola virus disease survivors and their Community Contacts in Bombali District, Sierra Leone. Our data suggest that the specie of Ebola virus (Zaire) responsible of the 2013-2016 epidemic in West Africa may cause mild or asymptomatic infection in a proportion of cases, possibly due to an efficient immune response.

scholarly journals Ebola virus disease: the ‘Black Swan’ in West Africa

2014 ◽  
Vol 45 (1) ◽  
pp. 2-5 ◽  
Author(s):  
Colin Brown ◽  
Paul Arkell ◽  
Sakib Rokadiya
Keyword(s):  
West Africa ◽  
Ebola Virus ◽  
Virus Disease ◽  
Ebola Virus Disease ◽  
Black Swan

scholarly journals Unintended consequences of the ‘bushmeat ban’ in West Africa during the 2013–2016 Ebola virus disease epidemic

2018 ◽  
Vol 200 ◽  
pp. 166-173 ◽  
Author(s):  
Jesse Bonwitt ◽  
Michael Dawson ◽  
Martin Kandeh ◽  
Rashid Ansumana ◽  
Foday Sahr ◽  
...  
Keyword(s):  
West Africa ◽  
Ebola Virus ◽  
Virus Disease ◽  
Unintended Consequences ◽  
Ebola Virus Disease

scholarly journals Ebola virus disease control (in West Africa): an ecological, one health approach

2015 ◽  
Vol 21 ◽  
Author(s):  
Clement Adebajo Meseko ◽  
Adeniyi Olugbenga Egbetade ◽  
Shamsudeen Fagbo
Keyword(s):  
West Africa ◽  
Disease Control ◽  
One Health ◽  
Ebola Virus ◽  
Virus Disease ◽  
Ebola Virus Disease
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