scholarly journals Ebola virus disease control (in West Africa): an ecological, one health approach

Author(s):  
Clement Adebajo Meseko ◽  
Adeniyi Olugbenga Egbetade ◽  
Shamsudeen Fagbo
2021 ◽  
Vol 12 (1) ◽  
Author(s):  
T. R. W. Tipton ◽  
Y. Hall ◽  
J. A. Bore ◽  
A. White ◽  
L. S. Sibley ◽  
...  

AbstractZaireebolavirus (EBOV) is a highly pathogenic filovirus which can result in Ebola virus disease (EVD); a serious medical condition that presents as flu like symptoms but then often leads to more serious or fatal outcomes. The 2013–16 West Africa epidemic saw an unparalleled number of cases. Here we show characterisation and identification of T cell epitopes in surviving patients from Guinea to the EBOV glycoprotein. We perform interferon gamma (IFNγ) ELISpot using a glycoprotein peptide library to identify T cell epitopes and determine the CD4+ or CD8+ T cell component response. Additionally, we generate data on the T cell phenotype and measure polyfunctional cytokine secretion by these antigen specific cells. We show candidate peptides able to elicit a T cell response in EBOV survivors and provide inferred human leukocyte antigen (HLA) allele restriction. This data informs on the long-term T cell response to Ebola virus disease and highlights potentially important immunodominant peptides.


2016 ◽  
Vol 339 (11-12) ◽  
pp. 517-528 ◽  
Author(s):  
Alexandre Hassanin ◽  
Nicolas Nesi ◽  
Julie Marin ◽  
Blaise Kadjo ◽  
Xavier Pourrut ◽  
...  

Author(s):  
Nadege Goumkwa Mafopa ◽  
Gianluca Russo ◽  
Raoul Emeric Guetiya Wadoum ◽  
Emmanuel Iwerima ◽  
Vincent Batwala ◽  
...  

A serosurvey of anti-Ebola Zaire virus nucleoprotein IgG prevalence was carried out among Ebola virus disease survivors and their Community Contacts in Bombali District, Sierra Leone. Our data suggest that the specie of Ebola virus (Zaire) responsible of the 2013-2016 epidemic in West Africa may cause mild or asymptomatic infection in a proportion of cases, possibly due to an efficient immune response.


2014 ◽  
Vol 45 (1) ◽  
pp. 2-5 ◽  
Author(s):  
Colin Brown ◽  
Paul Arkell ◽  
Sakib Rokadiya

2018 ◽  
Vol 200 ◽  
pp. 166-173 ◽  
Author(s):  
Jesse Bonwitt ◽  
Michael Dawson ◽  
Martin Kandeh ◽  
Rashid Ansumana ◽  
Foday Sahr ◽  
...  

2019 ◽  
Vol 25 (11) ◽  
pp. 1307-1314 ◽  
Author(s):  
A.M. Rojek ◽  
A. Salam ◽  
R.J. Ragotte ◽  
E. Liddiard ◽  
A. Elhussain ◽  
...  

2015 ◽  
Vol 8 ◽  
pp. IDRT.S31568 ◽  
Author(s):  
Kai-Lit Phua

Even if an effective vaccine against Ebola virus disease (EVD) becomes available, the challenges posed by this disease are complex. Certain socioeconomic and cultural factors have been linked to recent outbreaks of EVD in West Africa. The outbreaks revealed widespread ignorance by laypersons of EVD etiology, mode of transmission, and personal protective measures that can be taken. Lack of trust in the authorities, virus infection during the preparation of “bushmeat” for human consumption, traditional funerary practices, and relatively free flow of goods and people between regions and across international borders may have facilitated the spread of EVD and hindered outbreak control efforts. Inadequacy in health systems of the most seriously affected countries, such as Guinea, Sierra Leone, and Liberia, is also an important factor. The objectives of this article are to argue that EVD should be evaluated in a systematic and holistic manner and that this can be done through the use of the modified Haddon Matrix.


2017 ◽  
Vol 145 (9) ◽  
pp. 1961-1961
Author(s):  
Z. S. Y. WONG ◽  
C. M. BUI ◽  
A. A. CHUGHTAI ◽  
C. R. MACINTYRE

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