scholarly journals Vaccination of calves with Mycobacterium bovis Bacillus Calmette-Guerin reduces the frequency and severity of lesions of bovine tuberculosis under a natural transmission setting in Ethiopia

2017 ◽  
Vol 65 (1) ◽  
pp. 96-104 ◽  
Author(s):  
G. Ameni ◽  
K. Tafess ◽  
A. Zewde ◽  
T. Eguale ◽  
M. Tilahun ◽  
...  
Keyword(s):  
Mycobacterium Bovis ◽  
Bovine Tuberculosis ◽  
Bacillus Calmette Guerin ◽  
Transmission Setting

Vaccination of Holstein heifers with Mycobacterium bovis BCG strain induces protection against bovine tuberculosis and higher milk production yields in a natural transmission setting

2021 ◽  
Author(s):  
Patricio Retamal ◽  
Pedro Ábalos ◽  
Raúl Alegría ◽  
Nicolás Valdivieso ◽  
Martin Vordermeier ◽  
...  
Keyword(s):  
Milk Production ◽  
Mycobacterium Bovis ◽  
Bovine Tuberculosis ◽  
Mycobacterium Bovis Bcg ◽  
Transmission Setting

scholarly journals Improved Skin Test for Differential Diagnosis of Bovine Tuberculosis by the Addition of Rv3020c-Derived Peptides

2012 ◽  
Vol 19 (4) ◽  
pp. 620-622 ◽  
Author(s):  
Gareth J. Jones ◽  
Adam Whelan ◽  
Derek Clifford ◽  
Mick Coad ◽  
H. Martin Vordermeier
Keyword(s):  
Differential Diagnosis ◽  
Skin Test ◽  
Mycobacterium Bovis ◽  
Bovine Tuberculosis ◽  
Johne's Disease ◽  
Diagnostic Sensitivity ◽  
Bacillus Calmette Guerin ◽  
Content Type ◽  
The Face ◽  
Mycobacterial Antigens

ABSTRACTA peptide cocktail derived from the mycobacterial antigens ESAT-6, CFP-10, and Rv3615c allowed differentiation betweenMycobacterium bovis-infected and M. bovis bacillus Calmette-Guérin (BCG)-vaccinated cattle when used as a skin test reagent for a “DIVA” test (i.e., a test capable ofdifferentiatinginfected and uninfectedvaccinatedanimals). Addition of the antigen Rv3020c improves the diagnostic sensitivity without compromising specificity in the face of BCG or Johne's disease vaccination.

scholarly journals Field evaluation of Specific Mycobacterial Proteins-Based Skin Test for the Differentiation of Mycobacterium bovis-Infected and Bacillus Calmette Guerin-Vaccinated Crossbred Cattle in Ethiopia

2021 ◽  
Author(s):  
Berecha Bayissa ◽  
Aboma Zewude ◽  
Adane Worku ◽  
Balako Gumi ◽  
Stefan Berg ◽  
...  
Keyword(s):  
Skin Test ◽  
Mycobacterium Bovis ◽  
Control Strategy ◽  
Bovine Tuberculosis ◽  
Field Evaluation ◽  
Dairy Production ◽  
Bacillus Calmette Guerin ◽  
Crossbred Cattle ◽  
Test Reactions ◽  
Higher Sensitivity

Bovine tuberculosis (bTB) challenges intensive dairy production in Ethiopia and implementation of the test and slaughter control strategy is not economically acceptable in the country. Vaccination of cattle with Bacillus Calmette-Guerin (BCG) could be an important adjunct to control, which would require a diagnostic test to differentiate Mycobacterium bovis (M. bovis)-infected and BCG-vaccinated animals (DIVA role). This study describes evaluation of a DIVA skin test (DST) that is based on a cocktail (DSTc) or fusion (DSTf) of specific (ESAT-6, CFP-10 and Rv3615c) M. bovis proteins in Zebu-Holstein crossbred cattle in Ethiopia. The study animals used were 74 calves (35 BCG-vaccinated and 39 unvaccinated) aged less than three weeks at the start and 68 known bTB positive cows. Six weeks after vaccination, the 74 calves were tested with DSTc and the single intradermal cervical comparative tuberculin (SICCT) test. The cows were tested with DSTc and SICCT test. Reactions to DSTc were not observed in BCG-vaccinated and unvaccinated calves while SICCT test reactions were detected in vaccinated calves. DSTc reactions were detected in 95.6% of the cows and single intradermal tuberculin (SIT) positive reactions were found in 98.2% (95% confidence interval, CI, 92.1–100%). The sensitivity of DSTc was 95.6% (95% CI, 87.6–99.1%), and significantly (P<0.001) higher than the sensitivity (75%, 95% CI, 63.0-84.7%) of the SICCT test at 4mm cutoff. DSTf and DSTc reactions were correlated (r = 0.75; 95% CI =0.53–0.88). In conclusion, DSTc could differentiate M. bovis-infected from BCG-vaccinated cattle in Ethiopia. DST had higher sensitivity than the SICCT test. Hence, DSTc could be used as a diagnostic tool for bTB if BCG vaccination is implemented for the control of bTB in Ethiopia and other countries.

scholarly journals Prosthetic joint infection with pseudo-tumoral aspect due to Mycobacterium bovis infection after Bacillus-Calmette-Guerin therapy

2018 ◽  
Vol 61 (1) ◽  
pp. 62-64 ◽  
Author(s):  
B. Metayer ◽  
P. Menu ◽  
L. Khatchatourian ◽  
P. Preuss ◽  
M. Dauty ◽  
...  
Keyword(s):  
Mycobacterium Bovis ◽  
Prosthetic Joint Infection ◽  
Joint Infection ◽  
Bacillus Calmette Guerin ◽  
Prosthetic Joint

Mycobacterium bovis Bacillus Calmette-Guérin Killed by Extended Freeze-Drying Reduces Colitis in Mice

2011 ◽  
Vol 141 (2) ◽  
pp. 642-652.e4 ◽  
Author(s):  
Micheline Lagranderie ◽  
Christoph Kluge ◽  
Helene Kiefer–Biasizzo ◽  
Mohammad Abolhassani ◽  
Marie–Anne Nahori ◽  
...  
Keyword(s):  
Mycobacterium Bovis ◽  
Freeze Drying ◽  
Bacillus Calmette Guerin

scholarly journals Immune Responses to Defined Antigens of Mycobacterium bovis in Cattle Experimentally Infected with Mycobacterium kansasii

2006 ◽  
Vol 13 (6) ◽  
pp. 611-619 ◽  
Author(s):  
W. R. Waters ◽  
M. V. Palmer ◽  
T. C. Thacker ◽  
J. B. Payeur ◽  
N. B. Harris ◽  
...  
Keyword(s):  
Mycobacterium Bovis ◽  
Bovine Tuberculosis ◽  
Nontuberculous Mycobacteria ◽  
Gamma Interferon ◽  
Delayed Type Hypersensitivity ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Antibodies ◽  
Specific Serum ◽  
Specific Proteins

ABSTRACT Cross-reactive responses elicited by exposure to nontuberculous mycobacteria often confound the interpretation of antemortem tests for Mycobacterium bovis infection of cattle. The use of specific proteins (e.g., ESAT-6, CFP-10, and MPB83), however, generally enhances the specificity of bovine tuberculosis tests. While genes for these proteins are absent from many nontuberculous mycobacteria, they are present in M. kansasii. Instillation of M. kansasii into the tonsillar crypts of calves elicited delayed-type hypersensitivity and in vitro gamma interferon and nitrite concentration responses of leukocytes to M. avium and M. bovis purified protein derivatives (PPDs). While the responses of M. kansasii-inoculated calves to M. avium and M. bovis PPDs were approximately equivalent, the responses of M. bovis-inoculated calves to M. bovis PPD exceeded their respective responses to M. avium PPD. The gamma interferon and nitrite responses of M. kansasii-inoculated calves to recombinant ESAT-6-CFP-10 (rESAT-6-CFP-10) exceeded corresponding responses of noninoculated calves as early as 15 and 30 days after inoculation, respectively, and persisted throughout the study. The gamma interferon and nitrite responses of M. bovis-inoculated calves to rESAT-6-CFP-10 exceeded the corresponding responses of M. kansasii-inoculated calves beginning 30 days after inoculation. By using a lipoarabinomannan-based enzyme-linked immunosorbent assay, specific serum antibodies were detected as early as 50 days after challenge with M. kansasii. By a multiantigen print immunoassay and immunoblotting, serum antibodies to MPB83, but not ESAT-6 or CFP-10, were detected in M. kansasii-inoculated calves; however, responses to MPB83 were notably weaker than those elicited by M. bovis infection. These findings indicate that M. kansasii infection of calves elicits specific responses that may confound the interpretation of bovine tuberculosis tests.

scholarly journals Impact of in vitro evolution on antigenic diversity of Mycobacterium bovis bacillus Calmette-Guerin (BCG)

Vaccine ◽  
2014 ◽  
Vol 32 (45) ◽  
pp. 5998-6004 ◽  
Author(s):  
Richard Copin ◽  
Mireia Coscollá ◽  
Efstratios Efstathiadis ◽  
Sebastien Gagneux ◽  
Joel D. Ernst
Keyword(s):  
Mycobacterium Bovis ◽  
Bacillus Calmette Guerin ◽  
In Vitro Evolution ◽  
Antigenic Diversity

scholarly journals Use of ethanol extract of Mycobacterium bovis for detection of specific antibodies in sera of farmed red deer (Cervus elaphus) with bovine tuberculosis

2013 ◽  
Vol 9 (1) ◽  
pp. 256 ◽  
Author(s):  
Ashutosh Wadhwa ◽  
Rachel E Johnson ◽  
Colin G Mackintosh ◽  
J Frank T Griffin ◽  
W Waters ◽  
...  
Keyword(s):  
Mycobacterium Bovis ◽  
Cervus Elaphus ◽  
Bovine Tuberculosis ◽  
Red Deer ◽  
Ethanol Extract ◽  
Specific Antibodies

scholarly journals The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine

npj Vaccines ◽  
2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Junli Li ◽  
Lingjun Zhan ◽  
Chuan Qin
Keyword(s):  
Literature Review ◽  
Experimental Evidence ◽  
Mycobacterium Bovis ◽  
Virus Disease ◽  
Bcg Vaccine ◽  
Bacillus Calmette Guerin ◽  
Mycobacterial Infections ◽  
Specific Effects ◽  
Mycobacterial Diseases ◽  
Protection Mechanisms

AbstractBacillus Calmette–Guérin (BCG), the only vaccine proven to be effective against tuberculosis (TB), is the most commonly used vaccine globally. In addition to its effects on mycobacterial diseases, an increasing amount of epidemiological and experimental evidence accumulated since its introduction in 1921 has shown that BCG also exerts non-specific effects against a number of diseases, such as non-mycobacterial infections, allergies and certain malignancies. Recent Corona Virus Disease 2019 (COVID-19) outbreak has put BCG, a classic vaccine with significant non-specific protection, into the spotlight again. This literature review briefly covers the diverse facets of BCG vaccine, providing new perspectives in terms of specific and non-specific protection mechanisms of this old, multifaceted, and controversial vaccine.

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