High‐risk transmission clusters of leprosy in an endemic area in the Northeastern Brazil: a retrospective spatiotemporal modelling (2001 ‐ 2019)

Abstract Multidrug-resistant (MDR) and hypervirulent Klebsiella pneumoniae (hvKp) clones have become a major threat to global public health. The CG258 is considered a high-risk CG and the K. pneumoniae strains belonging to it are known to be often multi-resistant and to spread mainly in the hospital environment. This study aimed to characterize the antimicrobial resistance profile, virulence factors, and the clonal relationships among 13 K. pneumoniae strains belonging to CG258 from patients admitted to a tertiary hospital in Teresina, in the state of Piauí, northeastern Brazil. Ten strains were classified as MDR and three as extensively drug-resistant (XDR). Three different β-lactamase-encoding genes ( bla KPC , bla OXA-1- like , and bla CTX-M-Gp1) and six virulence genes ( fimH , ycfM , mrkD , entB , ybtS , and kfu ) were detected. Moreover, two hypermucoviscous K. pneumoniae strains and one capsular K-type 2 were found. Multilocus sequence typing analysis revealed 10 different sequence types (STs) (ST14, ST17, ST20, ST29, ST45, ST101, ST268, ST1800, ST3995, and ST3996) belonging to CG258, being two (ST3995 and ST3996) described for the first time in this study.

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Chagas disease: morbidity profile in an endemic area of Northeastern Brazil

Revista da Sociedade Brasileira de Medicina Tropical ◽

10.1590/0037-8682-0235-2015 ◽

2015 ◽

Vol 48 (6) ◽

pp. 706-715 ◽

Cited By ~ 10

Author(s):

Cléber de Mesquita Andrade ◽

Antônia Cláudia Jácome da Câmara ◽

Daniela Ferreira Nunes ◽

Paulo Marcos da Matta Guedes ◽

Wogelsanger Oliveira Pereira ◽

...

Keyword(s):

Chagas Disease ◽

Endemic Area ◽

Northeastern Brazil

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BROCA gene panel testing in African descendants from northeastern Brazil: Genetic susceptibility profile of an admixed population.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.1572 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. 1572-1572 ◽

Cited By ~ 1

Author(s):

Gabriela Espirito Santo Felix ◽

Yonglan Zheng ◽

Rodrigo Santa Cruz Guindalini ◽

Taisa Manuela Bonfim Machado-Lopes ◽

Jing Zhang ◽

...

Keyword(s):

Breast Cancer ◽

High Risk ◽

Cancer Patients ◽

Northeastern Brazil ◽

Breast Cancer Patients ◽

Recurrent Mutations ◽

African Descendants ◽

High Risk Breast Cancer ◽

High Risk Breast ◽

Risk Breast Cancer

1572 Background: The rising global burden of breast cancer (BC) in developing countries demands innovative interventions to accelerate progress in cancer control and prevention. Given the high rates of aggressive young onset breast cancer in Brazil, we sought to examine genetic susceptibility to the disease in the State of Bahia in the Northeast of Brazil, which has the largest population of African descendants. Methods: We screened cases, high-risk breast cancer patients with and without family history of breast cancer, and controls (cancer-free women) for twenty-eight breast cancer susceptibility genes using a validated targeted capture and multiplex sequencing approach – the BROCA panel. Each participant gave informed consent under IRB approved protocols and provided clinical-pathological and epidemiological data. Results: A total of 292 consecutive and unrelated individuals (173 cases and 119 controls) were included. Nearly 2/3rds of the cases (116/173) and about 90% of the controls (108/119) self-reported as African-descendant. Mutations considered pathogenic were identified in 37 (21.4%) cases and in one control (0.84%, RAD51C c.266insA), OR = 27.75 and p = 0.008. The mutated genes in cases were BRCA1 (in 12 patients), BRCA2 (10), ATM (3), PALB2 (3), BRIP1 (3), BRCA2/ BARD1 (1), FAM175A (1), FANCM (1), NBN (1), SLX4 (1) and TP53 (1). Three recurrent mutations accounted for 12.4% (9/37) of the total: 3 BRCA1 c.3331_3334delCAAG (known European mutation), 3 BRCA1 c.211A > G (known Galician mutation), and 3 PALB2c.1671_1674delTATT (novel mutation). Conclusions: Mutations in BRCA1 and BRCA2 (64.85%) or another breast cancer gene (35.15%) occur in one in five high-risk breast cancer patients in the largest study of Northeastern Brazil to date, and a significant proportion were recurrent mutations of European origin, which can be explained by the admixture pattern of the Brazilian population. This result underscores the importance of using multigene panel in cancer genetic epidemiologic research of understudied populations where unexpected findings, such as the recurrent and novel variant in PALB2 c.1671_1674delTATT, can be detected.

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