scholarly journals The safety of COVID ‐19 convalescent plasma donation: A multi‐institutional donor hemovigilance study

Transfusion ◽  
2021 ◽  
Author(s):  
Joseph H. Cho ◽  
Srijana Rajbhandary ◽  
Nancy L. van Buren ◽  
Mark K. Fung ◽  
Maha Al‐Ghafry ◽  
...  
Keyword(s):  
Plasma Donation

The novel use of convalescent plasma in patients with COVID 19 in Basra governorate, Case series review

2020 ◽  
pp. 1-10 ◽  
Author(s):  
Saad Hammadi ◽  
Ali Hashim ◽  
Abbas Ali ◽  
Rafid Abbood ◽  
Hassanein Ali ◽  
...  
Keyword(s):  
Plasma Exchange ◽  
Case Series ◽  
Passive Immunity ◽  
The Novel ◽  
Efficacy And Safety ◽  
Off Label Use ◽  
Plasma Therapy ◽  
Off Label ◽  
Plasma Donation ◽  
Patient Series

Background: The idea of convalescent plasma usage is to give passive immunity to the patients, so their immune system stands a good chance of combating the virus.this study will review 6 cases of eligible covid 19 patients that had been treated with convalescent plasma therapy in Basra covid 19 quarantine Objectives: to demonstrate efficacy and safety of convalescent plasma in the patient series that had been enrolled . Method: this study had pioneered a new method to collect up to 3,000 mL in one session by an off-label use of Spectra Optia Apheresis systems by TerumoBCT /Exchange set to collect convalescent plasma. In this study 250 mL convalescent plasma had been given each of the 6 patients, from one donor. respose in spo2,dyspnoea and tachypnoea was observed ,any reaction to plasma also had been monitored . Result: Our case series have demonstrated both safety and effectiveness of convalescent plasma. This study was successful in reaching our primary and secondary outcomes in all 6 patients (improvement in SpO2 and symptoms). With negligible difference in time of post transfusion response Conclusion: convalescent plasma is apperantly safe and effective, In this study 250 mL convalescent plasma had been given each of the 6 patients, from one donor using Therapeutic Plasma Exchange (TPE) protocol by Spectra Optia Apheresis system/TerumoBCT. Keywords: convalescent plasma, COVID-19, SARS CoV-2, apheresis, plasma exchange, plasma donation

scholarly journals Study protocol for a randomised controlled trial examining the effect of blood and plasma donation on serum perfluoroalkyl and polyfluoroalkyl substance (PFAS) levels in firefighters

BMJ Open ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. e044833
Author(s):  
Gabriel Silver ◽  
Yordanka Krastev ◽  
Miriam K Forbes ◽  
Brenton Hamdorf ◽  
Barry Lewis ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Health Effects ◽  
Whole Blood ◽  
Sulfonic Acid ◽  
Controlled Trial ◽  
Adverse Health Effects ◽  
Plasma Donation ◽  
Adverse Health ◽  
Study Results ◽  
Randomised Controlled

IntroductionPerfluoroalkyl and polyfluoroalkyl substances (PFAS) are a diverse group of compounds that have been used in hundreds of industrial applications and consumer products including aqueous film-forming foam (AFFF) for many years. Multiple national and international health and environmental agencies have accepted that PFAS exposures are associated with numerous adverse health effects. Australian firefighters have been shown to have elevated levels of PFAS in their blood, specifically perfluorooctane sulfonic acid (PFOS) and perfluorohexane sulfonic acid (PFHxS), due to the historical use of AFFF. While PFAS concentrations decline over time once the source of exposure has been removed, their potential adverse health effects are such that it would be prudent to develop an intervention to lower levels at a faster rate than occurs via natural elimination rates.Methods and analysisThis is a randomised controlled trial of current and former Australian firefighters in the Metropolitan Fire Brigade/Fire Rescue Victoria, and contractors, with previous occupational exposure to PFAS and baseline elevated PFOS levels. The study is investigating whether whole blood donation every 12 weeks or plasma donation every 6 weeks will significantly reduce PFAS levels, compared with a control group. We have used covariate-adaptive randomisation to balance participants’ sex and blood PFAS levels between the three groups and would consider a 25% reduction in serum PFOS and PFHxS levels to be potentially clinically significant after 12 months of whole blood or plasma donation. A secondary analysis of health biomarkers is being made of changes between screening and week 52 in all three groups.Ethics and disseminationThis trial has been approved by Macquarie University Human Research Ethics Committee (reference number: 3855), final protocol V.2 dated 12 June 2019. Study results will be disseminated via peer-reviewed publications and presentations at conferences.Trial registration numberAustralian New Zealand Clinical Trials Registry (ACTRN12619000204145).

The Complex Biochemical Study of the Blood Plasma, Obtained by Manual Plasmapheresis

2016 ◽  
pp. 155-157
Author(s):  
Andrii Korzh
Keyword(s):  
Blood Plasma ◽  
Biochemical Parameters ◽  
Biochemical Study ◽  
Plasma Samples ◽  
Fluorometric Method ◽  
Plasma Donation ◽  
Individual Index ◽  
First Time ◽  
Age And Sex ◽  
Donor Plasma

The plasma samples of 34 primary donors (22 men and 12 women) for the first time given the plasma by automated plasmapheresis (control surveillance), and 54 active donors of blood plasma (40 men and 14 women) being donors with non-less 14 days interval between donations, have been examined. The active male donors’ plasma averaged at 18,63±1,71 with individual index fluctuations from 2 to 78, female donors’ – 14,09±1,95 with individual index fluctuations from 2 to 45. The method of plasma obtaining is a manual plasmapheresis method. The surveyed groups were homogeneous for age and sex. Hematologic and biochemical parameters of all those persons have been examined and, basing on the conclusion of the professionals, everyone was admitted to the plasma donation. The content of middle mass molecules in plasma were determined by method of N.I. Gabrieljan, V.I. Lipatovoj (1984). The content of biogenic amines free fractions in plasma were determined by fluorometric method of B.V. Mikhailichenko, S.V. Vydyborets (1999). Analysis of the results showed that in the donor plasma samples obtained by manual plasmapheresis level of middle mass molecules, histamine, serotonin is significantly higher. The significance of obtained results has also been discussed.

PlasmaBlock: a plasma donation blockchain system in COVID-19

2021 ◽  
Vol 25 (3/4) ◽  
pp. 268
Author(s):  
Riya Sapra ◽  
Parneeta Dhaliwal
Keyword(s):  
Plasma Donation

Retrospective analysis of persons after mild COVID-19 in the context of a convalescent plasma donation

2021 ◽  
Author(s):  
T Flieder ◽  
M Wolny ◽  
K von Bargen ◽  
F Knüttgen ◽  
T Vollmer ◽  
...  
Keyword(s):  
Retrospective Analysis ◽  
Plasma Donation

The Ethics of Paid Plasma Donation: A Plea for Patient Centeredness

HEC Forum ◽  
2014 ◽  
Vol 27 (4) ◽  
pp. 417-429 ◽  
Author(s):  
Albert Farrugia ◽  
Joshua Penrod ◽  
Jan M. Bult
Keyword(s):  
Patient Centeredness ◽  
Plasma Donation

Reply to Discussion of “Effect of plasma donation and blood donation on aerobic and anaerobic responses in exhaustive, severe-intensity exercise”

2014 ◽  
Vol 39 (3) ◽  
pp. 400-400
Author(s):  
David W. Hill ◽  
Jakob L. Vingren ◽  
Samantha D. Burdette
Keyword(s):  
Blood Donation ◽  
Plasma Donation ◽  
Severe Intensity ◽  
Aerobic And Anaerobic

Response to Volkow P et al. – Cross-border paid plasma donation among injection drug users in two Mexico–U.S. border cities – International Journal of Drug Policy 20 (2009) 409–412

2010 ◽  
Vol 21 (5) ◽  
pp. 343-344 ◽  
Author(s):  
Joshua Penrod ◽  
Mary Gustafson ◽  
George Schreiber ◽  
Jan Bult ◽  
Albert Farrugia
Keyword(s):  
Drug Policy ◽  
Injection Drug Users ◽  
Drug Users ◽  
Injection Drug ◽  
Cross Border ◽  
Plasma Donation

scholarly journals Persons with Early Syphilis Identified through Blood or Plasma Donation Screening in the United States

2002 ◽  
Vol 185 (4) ◽  
pp. 545-549 ◽  
Author(s):  
Carolyn Gardella ◽  
Anthony A. Marfin ◽  
Richard H. Kahn ◽  
Emmett Swint ◽  
Lauri E. Markowitz
Keyword(s):  
United States ◽  
The United States ◽  
Early Syphilis ◽  
Plasma Donation
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