Identification of novel tumour-associated antigens in canine mammary gland tumour

An 11-year-old, female Maltese was presented for evaluation of a mammary gland tumour. An abdominal sonographic examination showed an echogenic, fluid-filled, dilated uterus; pyometra was also diagnosed. Ovariohysterectomy and unilateral mastectomy was performed and the dog recovered uneventfully. However, 11 h later, the dog’s condition suddenly deteriorated and it died on the day after the surgery. Bacillus circulans and Bacillus megaterium were isolated from its uterine content; these species had not been reported previously in canine pyometra. The two species were resistant to various antibiotics, including cefazolin used during the treatment. We describe for the first time the presentation, diagnosis, bacterial isolation and fatal outcome of B. circulans and B. megaterium infection in a Maltese dog with pyometra.

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Fractal dimension of canine mammary gland epithelial tumors on cytologic smears

Veterinary Clinical Pathology ◽

10.1111/j.1939-165x.2006.tb00162.x ◽

2006 ◽

Vol 35 (4) ◽

pp. 446-448 ◽

Cited By ~ 12

Author(s):

Radostin Simeonov ◽

Galina Simeonova

Keyword(s):

Fractal Dimension ◽

Mammary Gland ◽

Epithelial Tumors ◽

Canine Mammary Gland

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Combined detection of CA15-3, CEA, and SF in serum and tissue of canine mammary gland tumor patients

Scientific Reports ◽

10.1038/s41598-021-85029-4 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Yuying Fan ◽

Xiaoli Ren ◽

Xuesong Liu ◽

Dongmei Shi ◽

Enshuang Xu ◽

...

Keyword(s):

Mammary Gland ◽

Malignant Tumor ◽

Reference Value ◽

Detection Sensitivity ◽

Control Group ◽

Tumor Group ◽

Increased Sensitivity ◽

Sensitivity Specificity ◽

Canine Mammary Gland ◽

Combined Detection

AbstractThe purpose of this study is to evaluate the levels and clinical diagnosis value of CA15-3, CEA, and SF in canine mammary gland tumors (CMGTs). In this study, the levels of tissues/serum CA15-3, CEA, and SF in 178 CMGT patients or healthy dogs were determined by ELISA and qRT-PCR assay. CA15-3, CEA, and SF levels of the malignant tumor group were significantly higher than that of the benign tumor group and the healthy control group. In the malignant tumor group, CA15-3 held a sensitivity of 51.8%, a specificity of 93.9%, and an accuracy of 76.8%. The sensitivity, specificity, and accuracy of CEA were 44.6%, 84.1%, and 68.1% respectively. SF held a sensitivity of 62.5%, a specificity of 85.4%, and an accuracy of 76.1%. SF showed the highest sensitivity and CA15-3 showed the highest specificity. The sensitivity, specificity, and accuracy of the combined detection of the three biomarkers in malignant tumor groups were 80.4%, 78.0%, and 80.0%, respectively, therefore combined detection increased sensitivity and accuracy but decreased specificity. In conclusion, the combined detection of serum/tissue markers CA15-3, CEA, and SF may improve the detection sensitivity of CMGTs, providing reference value for clinical application.

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