The frequency of feline AB blood types and the risk of incompatibility reactions in Bangkok, Thailand, and vicinities

Abstract Background We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study of three independent cohorts of critically ill patients from the United States and Scandinavia consisting of adults with septic shock. We compared the 30-day mortality across the blood types within each cohort and pooled the results in a meta-analysis. We also estimated the incidence of AKI and degree of endothelial damage, as measured by blood concentrations of soluble thrombomodulin and syndecan-1. Results We included 12,342 patients with severe sepsis. In a pooled analysis blood type B carried a slightly lower risk of 30-day all-cause mortality compared to non-blood type B (adjusted HR 0.88; 95%-CI 0.79–0.98; p = 0.02). There was no difference in the risk of AKI. Soluble thrombomodulin and syndecan-1 concentrations were lower in patients with blood type B and O compared to blood type A, suggesting less endothelial damage. Conclusion Septic patients with blood type B had less endothelial damage, and a small reduction in mortality. The exposure is, however, unmodifiable.

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Association between ABO and Duffy blood types and circulating chemokines and cytokines

Genes and Immunity ◽

10.1038/s41435-021-00137-5 ◽

2021 ◽

Author(s):

Sarah C. Van Alsten ◽

John G. Aversa ◽

Loredana Santo ◽

M. Constanza Camargo ◽

Troy Kemp ◽

...

Keyword(s):

Blood Types

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Molecular characterization of cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) gene and frequency of blood types in stray cats of İzmir, Turkey

BMC Genomics ◽

10.1186/s12864-021-07588-0 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Hüseyin Can ◽

Sedef Erkunt Alak ◽

Ahmet Efe Köseoğlu ◽

Umut Şahar ◽

Berna Bostanbaş ◽

...

Keyword(s):

Type A ◽

Type B ◽

Exon 2 ◽

Blood Types ◽

Acetylneuraminic Acid ◽

Stray Cats ◽

High Prevalence ◽

Heterozygous Form ◽

Type Ab ◽

First Time

Abstract Background Cytidine monophospho-n-acetylneuraminic acid hydroxylase (CMAH) gene associated with blood groups in cats encodes CMAH enzyme that converts Neu5Ac to Neu5Gc. Although variations in CMAH gene of pedigree cats have been revealed, the presence/lack of them in non-pedigree stray cats is unknown. Therefore, the present study aimed to investigate the variations in CMAH gene and the quantity of Neu5Ac and Neu5Gc on erythrocytes of non-pedigree stray cats (n:12) living in İzmir, Turkey. Also, the frequency of blood types was determined in 76 stray cats including 12 cats that were used for CMAH and Neu5A/Neu5Gc analysis. Results In total, 14 SNPs were detected in 5’UTR as well as in exon 2, 4, 9, 10, 11 and 12 of CMAH gene. Among these SNPs, -495 C > T in 5’UTR was detected for the first time as heterozygous in type A and AB cats, and homozygous and heterozygous in type B cats. The remaining 13 that have been detected in previous studies were also found as homozygous or heterozygous. Both Neu5Gc and Neu5Ac were detected in type A and AB cats. In type B cats, only Neu5Ac was detected. Among two type AB cats, the level of Neu5Ac was found higher in cat carrying heterozygous form (T/C) of 1392T > C. The prevalence of type B cats (67.1 %) was higher than others. Conclusions The presence of a new SNP as well as previous SNPs indicates that more variations can be found in stray cats with a more comprehensive study in the future. Also, the high prevalence of type B cats demonstrates the possible risk of neonatal isoerythrolysis among stray cats living in İzmir, Turkey.

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Genetic variability in the brazilian criollo horse breed

Ciência Rural ◽

10.1590/s0103-84782003000100022 ◽

2003 ◽

Vol 33 (1) ◽

pp. 137-142 ◽

Cited By ~ 1

Author(s):

Myriam Elizabeth Vinocur ◽

Karin Erica Brass ◽

Mara Iolanda Batistella Rubin ◽

Carlos Antonio Mondino Silva

Keyword(s):

Genetic Variability ◽

Rio Grande ◽

Blood Groups ◽

Rio Grande Do Sul ◽

Average Heterozygosity ◽

Horse Breed ◽

Allelic Frequencies ◽

Blood Types ◽

Inbreeding Level

Allelic frequencies of 7 blood groups and 8 protein systems were determined in 6 herds of Criollo horse breed raised in Rio Grande do Sul, Brazil. Analysis of these frequencies showed a significant isolation component (Fst = 0.0866; p<0.01) and construction of dendogram using Nei´s D confirmed this difference among the 6 herds. The highest values measuring genetic variability on 15 blood types were average heterozygosity: 0.4631; total number of alleles: 87 and probability of exclusion: 98%. When all herds were considered together, the inbreeding level (Fis) was zero. These results indicate that the Criollo horses have a large genetic variability.

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