Normal reference intervals and the effects of sample handling on dynamic viscoelastic coagulometry (Sonoclot) in healthy adult horses

Introduction: The aim of the study was to establish normal reference values obtained by fetal speckle tracking analysis of the fetal heart between 17-24 weeks of gestation among Thai fetuses and compare the nomograms with previous studies. Methods: The 4-chamber view of the fetal heart in 79 normal fetuses was analyzed by speckle tracking analysis to determine the best-fit regression model. The 95% reference intervals and Z-score equations of fetal cardiac parameters were computed. Results: The end-diastolic length, width, area, and circumference of the 4-chamber view (4CV) as well as the ventricular end-diastolic length, 24-segment widths, and area were all increased as a function of gestational age (GA) and 5 fetal biometric parameters. In contrast, the global sphericity index (SI), 24-segment SI, and right ventricle/left ventricle width and area ratios did not change with GA or fetal biometric measurements. There were few differences in Z-score reference ranges of fetal cardiac measurements between the current study and previous studies conducted in different patient populations. Conclusion: Our study provided z-score and corresponding centile calculators, 5th and 95th centile reference tables, and corresponding graphs for evaluating the size and shape of the 4CV and the right and left ventricles using 6 independent variables between 17 and 24 weeks of gestation. These results provide normal reference ranges for future studies of fetuses with pathologies that may alter the size and shape of the 4-chamber view and ventricles.

Download Full-text

Clinical chemistry reference intervals of healthy adult populations in Gojjam Zones of Amhara National Regional State, Northwest Ethiopia

PLoS ONE ◽

10.1371/journal.pone.0184665 ◽

2017 ◽

Vol 12 (9) ◽

pp. e0184665 ◽

Cited By ~ 4

Author(s):

Zewdie Mekonnen ◽

Asmare Amuamuta ◽

Wondemagegn Mulu ◽

Mulat Yimer ◽

Yohannes Zenebe ◽

...

Keyword(s):

Healthy Adult ◽

Clinical Chemistry ◽

Reference Intervals ◽

Northwest Ethiopia ◽

Regional State

Download Full-text

P1562 Normal reference values of three-dimensional speckle-tracking echocardiography-derived right atrial volumes and volume-based functional properties in healthy adult subjects

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jez319.983 ◽

2020 ◽

Vol 21 (Supplement_1) ◽

Author(s):

A Nemes ◽

A Kormanyos ◽

P Domsik ◽

A Kalapos ◽

N Ambrus ◽

...

Keyword(s):

Functional Properties ◽

Reference Values ◽

Speckle Tracking ◽

Healthy Adult ◽

Speckle Tracking Echocardiography ◽

Three Dimensional ◽

Right Atrial ◽

Normal Reference ◽

Significant Difference ◽

Significant Impairment

Abstract Introduction The right atrium (RA) has several roles including a systolic reservoir, early diastolic conduit and late-diastolic booster pump functions. The present study aimed to assess normal reference values of three-dimensional speckle-tracking echocardiography (3DSTE)-derived RA volumetric data and volume-based functional properties (stroke volumes, SVs and emptying fractions, EFs) in healthy adult subjects. Methods 260 healthy adult subjects in sinus rhythm with complete clinical and demographic dataset have been included in the present study. However, due to inferior image quality 110 subjects have been excluded. The remaining population comprised 150 cases (31.0 ± 11.6 years, 79 males). Complete two-dimensional Doppler echocardiography and 3DSTE have been performed in all subjects. Results While systolic maximum RA volume did not change over age decades, early and late-diastolic RA pre-atrial contraction volume and minimum RA volume increased over time. Significantly larger values could be detected in more than 50 year-old healthy subjects as compared to younger subjects. Total atrial SV remained almost unchanged over age decades with a significant reduction in subjects aged >50 years. Passive atrial SV showed a continuous reduction over age decades and significant difference could be demonstrated between subjects aged 18-29 years and >50 years. Active atrial SV increased over age decades with a significant reduction in subjects aged >50 years. Total atrial EF did not show any changes over age decades, but a significant reduction could be demonstrated in cases aged >50 years. Passive atrial EF showed significant continuous reduction over age decades. Active atrial EF did not change in younger ages, it was the highest at ages 40-49 years with a significant impairment after 50 years. Females proved to have tendentiously higher RA volumes respecting the cardiac cycle regardless of age. No significant differences could be demonstrated between RA stroke volumes between genders except between 40-49 years when females had tendentiously higher values. RA emptying fractions were non-significantly, but tendentiously higher in females as compared to that of males regardless of age. Conclusions Normal reference values of 3DSTE-derived RA volumes and volume-based functional properties and their age- and gender dependency were defined in healthy adult subjects.

Download Full-text

Basal plasma concentrations of routine variables and packed cell volume in clinically healthy adult small-sized dogs: effect of breed, body weight, age, and gender, and establishment of reference intervals

Veterinary Clinical Pathology ◽

10.1111/vcp.12162 ◽

2014 ◽

Vol 43 (3) ◽

pp. 371-380 ◽

Cited By ~ 11

Author(s):

Charlotte Misbach ◽

Valérie Chetboul ◽

Didier Concordet ◽

Christine Médaille ◽

Philippe Gruet ◽

...

Keyword(s):

Body Weight ◽

Cell Volume ◽

Packed Cell Volume ◽

Healthy Adult ◽

Plasma Concentrations ◽

Reference Intervals ◽

Age And Gender ◽

Basal Plasma ◽

And Gender

Download Full-text

Reference intervals of echocardiographic measurements in healthy adult dairy goats

PLoS ONE ◽

10.1371/journal.pone.0183293 ◽

2017 ◽

Vol 12 (8) ◽

pp. e0183293 ◽

Cited By ~ 4

Author(s):

Olga Szaluś-Jordanow ◽

Michał Czopowicz ◽

Lucjan Witkowski ◽

Marcin Mickiewicz ◽

Tadeusz Frymus ◽

...

Keyword(s):

Healthy Adult ◽

Reference Intervals ◽

Dairy Goats

Download Full-text

Automated kinetic assay of angiotensin-converting enzyme in serum.

Clinical Chemistry ◽

10.1093/clinchem/32.5.884 ◽

1986 ◽

Vol 32 (5) ◽

pp. 884-886 ◽

Cited By ~ 34

Author(s):

B Beneteau ◽

B Baudin ◽

G Morgant ◽

J Giboudeau ◽

F C Baumann

Keyword(s):

Angiotensin Converting Enzyme ◽

Oral Contraceptives ◽

Kinetic Method ◽

Reference Intervals ◽

Converting Enzyme ◽

Kinetic Assay ◽

Reaction Conditions ◽

Normal Reference ◽

Analytical Reliability ◽

Normal Adults

Abstract We have developed and validated an automated kinetic method for angiotensin-converting enzyme (EC 3.4.15.1) on the Olli C + D analyzer, modified from that of Ronca-Testoni (Clin Chem 1983;29:1093-6) with N-[3-(2-furyl)-acryloyl]-L-phenylalanylglycylglycine used as substrate. We have determined appropriate reaction conditions for the assay, verified the principal analytical reliability criteria (repeatability, reproducibility, sensitivity), and established normal reference intervals (mean +/- SD) for the enzyme's activity, using serum of normal adults (100 +/- 35 U/L, n = 150), newborns (130 +/- 27 U/L, n = 10), women taking oral contraceptives (103 +/- 30 U/L, n = 10), smokers (109 +/- 38 U/L, n = 27), and patients with sarcoidosis (220 +/- 48 U/L, n = 15).

Download Full-text