Preparation Of Cellulose Acetate Dialysis Membrane Using D–Glucose Monohydrate As Additive

Dialisis membran yang mengandungi sellulosa asetat (CA) sebagai polimer, asid formik (FA) sebagai pelarut dan glukosa-D monohidrat sebagai bahan tambah telah disediakan melalui proses fasa balikan. Objektif utama bagi penyelidikan ini adalah untuk menyelidik pengaruh bahan tambah glukosa–D terhadap prestasi membran dialisis dari segi pemisahan urea dan kreatinina. Kepekatan glukosa–D diubah daripada 2 hingga 10 wt%. Pemanasan menggunakan ketuhar mikrogelombang yang dapat memendekkan masa pelarutan digunakan untuk melarutkan CA polimer dalam pelarut asid formik. Keputusan menunjukkan bahawa membran yang dihasilkan daripada 20 wt% selulosa asetat, 70 wt% asid formik dan 10 wt% glukosa–D monohidrat memberi prestasi yang terbaik bagi penyingkiran urea and kreatinina sebanyak masing–masimg 49.77% dan 19.54%. Apabila membran yang sama dikaji bagi penahanan BSA, ia memberikan peratus penyingkiran larutan BSA sebanyak 96.78%. Berbanding dengan membran dialisis selulosa asetat komersial, didapati bahawa keputusan adalah memuaskan. Gambar SEM menunjukkan bahawa penambahan glukosa–D monohidrat dalam larutan memberi pembentukan struktur jejari. Kata kunci: Membran dialisis; selulosa asetat; penyingkiran urea; penyingkiran kreatinina; peratus penahanan BSA Dialysis membrane containing cellulose acetate (CA) as polymer, formic acid (FA) as solvent and D–glucose monohydrate as additive was prepared by phase inversion method. The main objective of this study is to investigate the influence of D–glucose monohydrate as an additive on the performance of dialysis membrane in terms of urea and creatinine clearance. The concentration of D–glucose is varied from 2 to 10 wt%. Microwave heating which is capable of reducing dissolution time was used to dissolve the CA polymer in the formic acid solvent. Results revealed that the membrane produced from the 20 wt% cellulose acetate, 70 wt% formic acid and 10 wt% D–glucose monohydrate gives the best performance with urea and creatinine clearance of 49.77% and 19.54% respectively. When testing the same membranes with BSA solutions, it gives a BSA rejection rate as high as 96.78%, which seems to be comparable with the commercial cellulose acetate dialysis membranes. Membrane morphology was observed by using a scanning electron microscopy (SEM). The SEM images illustrated that the increment of D–glucose monohydrate in casting solution tends to promote macrovoid formation. Key words: Dialysis membrane; cellulose acetate; SEM images; urea clearance; creatine clearance; BSA rejection rate