The effect of autologous repair and voluntary wheel running on force recovery in a rat model of volumetric muscle loss

2021 ◽  
Author(s):  
Tyrone A. Washington ◽  
Richard A. Perry ◽  
John T. Kim ◽  
Wesley S. Haynie ◽  
Nicholas P. Greene ◽  
...  
Keyword(s):  
Rat Model ◽  
Wheel Running ◽  
Muscle Loss ◽  
Voluntary Wheel Running ◽  
Volumetric Muscle Loss ◽  
Force Recovery ◽  
Voluntary Wheel

scholarly journals Impaired Voluntary Wheel Running Behavior in the Unilateral 6-Hydroxydopamine Rat Model of Parkinson's Disease

2015 ◽  
Vol 57 (2) ◽  
pp. 82 ◽  
Author(s):  
Qi Pan ◽  
Wangming Zhang ◽  
Jinyan Wang ◽  
Fei Luo ◽  
Jingyu Chang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Wheel Running ◽  
Voluntary Wheel Running ◽  
6 Hydroxydopamine ◽  
Voluntary Wheel

scholarly journals Voluntary Wheel Running Has Beneficial Effects in a Rat Model of CKD-Mineral Bone Disorder (CKD-MBD)

2019 ◽  
Vol 30 (10) ◽  
pp. 1898-1909 ◽  
Author(s):  
Keith G. Avin ◽  
Matthew R. Allen ◽  
Neal X. Chen ◽  
Shruthi Srinivasan ◽  
Kalisha D. O’Neill ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Rat Model ◽  
Wheel Running ◽  
Serum Biochemistry ◽  
Left Ventricular ◽  
Cystic Kidney Disease ◽  
Cystic Kidney ◽  
Voluntary Wheel Running ◽  
Exercise Interventions ◽  
Voluntary Wheel

BackgroundReduced bone and muscle health in individuals with CKD contributes to their higher rates of morbidity and mortality.MethodsWe tested the hypothesis that voluntary wheel running would improve musculoskeletal health in a CKD rat model. Rats with spontaneous progressive cystic kidney disease (Cy/+ IU) and normal littermates (NL) were given access to a voluntary running wheel or standard cage conditions for 10 weeks starting at 25 weeks of age when the rats with kidney disease had reached stage 2–3 of CKD. We then measured the effects of wheel running on serum biochemistry, tissue weight, voluntary grip strength, maximal aerobic capacity (VO2max), body composition and bone micro-CT and mechanics.ResultsWheel running improved serum biochemistry with decreased creatinine, phosphorous, and parathyroid hormone in the rats with CKD. It improved muscle strength, increased time-to-fatigue (for VO2max), reduced cortical porosity and improved bone microarchitecture. The CKD rats with voluntary wheel access also had reduced kidney cystic weight and reduced left ventricular mass index.ConclusionsVoluntary wheel running resulted in multiple beneficial systemic effects in rats with CKD and improved their physical function. Studies examining exercise interventions in patients with CKD are warranted.

scholarly journals Comparative adaptations in oxidative and glycolytic muscle fibers in a low voluntary wheel running rat model performing three levels of physical activity

2015 ◽  
Vol 3 (11) ◽  
pp. e12619 ◽  
Author(s):  
Hayden W. Hyatt ◽  
Ryan G. Toedebusch ◽  
Greg Ruegsegger ◽  
C. Brooks Mobley ◽  
Carlton D. Fox ◽  
...  
Keyword(s):  
Physical Activity ◽  
Rat Model ◽  
Wheel Running ◽  
Muscle Fibers ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

scholarly journals Skeletal muscle metabolic responses to physical activity are muscle type specific in a rat model of chronic kidney disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Keith G. Avin ◽  
Meghan C. Hughes ◽  
Neal X. Chen ◽  
Shruthi Srinivasan ◽  
Kalisha D. O’Neill ◽  
...  
Keyword(s):  
Physical Activity ◽  
Skeletal Muscle ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Rat Model ◽  
Mitochondrial Respiration ◽  
Wheel Running ◽  
Muscle Metabolism ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

AbstractChronic kidney disease (CKD) leads to musculoskeletal impairments that are impacted by muscle metabolism. We tested the hypothesis that 10-weeks of voluntary wheel running can improve skeletal muscle mitochondria activity and function in a rat model of CKD. Groups included (n = 12–14/group): (1) normal littermates (NL); (2) CKD, and; (3) CKD-10 weeks of voluntary wheel running (CKD-W). At 35-weeks old the following assays were performed in the soleus and extensor digitorum longus (EDL): targeted metabolomics, mitochondrial respiration, and protein expression. Amino acid-related compounds were reduced in CKD muscle and not restored by physical activity. Mitochondrial respiration in the CKD soleus was increased compared to NL, but not impacted by physical activity. The EDL respiration was not different between NL and CKD, but increased in CKD-wheel rats compared to CKD and NL groups. Our results demonstrate that the soleus may be more susceptible to CKD-induced changes of mitochondrial complex content and respiration, while in the EDL, these alterations were in response the physiological load induced by mild physical activity. Future studies should focus on therapies to improve mitochondrial function in both types of muscle to determine if such treatments can improve the ability to adapt to physical activity in CKD.

scholarly journals Voluntary wheel running complements microdystrophin gene therapy to improve muscle function in mdx mice

2021 ◽  
Author(s):  
S.E. Hamm ◽  
D.D. Fathalikhani ◽  
K.E. Bukovec ◽  
A.K. Addington ◽  
H. Zhang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Muscle Function ◽  
Wheel Running ◽  
Mdx Mice ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

Membrane Estrogen Receptors Regulate Voluntary Wheel Running and Contractile Function in Skeletal Muscle in Mice

2011 ◽  
Vol 43 (Suppl 1) ◽  
pp. 781
Author(s):  
Jacqueline M. Crissey ◽  
J. Andries Ferreira ◽  
Dennis B. Lubahn ◽  
Marybeth Brown
Keyword(s):  
Skeletal Muscle ◽  
Estrogen Receptors ◽  
Wheel Running ◽  
Contractile Function ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

scholarly journals Voluntary Wheel Running Selectively Augments Insulin-Stimulated Vasodilation in Arterioles from White Skeletal Muscle of Insulin-Resistant Rats

2012 ◽  
Vol 19 (8) ◽  
pp. 729-738 ◽  
Author(s):  
Catherine R. Mikus ◽  
Bruno T. Roseguini ◽  
Grace M. Uptergrove ◽  
E. Matthew Morris ◽  
Randy Scott Rector ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Wheel Running ◽  
Voluntary Wheel Running ◽  
Insulin Resistant ◽  
Voluntary Wheel

scholarly journals The Effect of Voluntary Wheel Running on Muscle Mass, Mitochondrial Function and Oxidative Damage in Sod1???/???mice

2006 ◽  
Vol 38 (Suppl 1) ◽  
pp. S12
Author(s):  
Michael S. Lustgarten ◽  
Young C. Jang ◽  
Wook Song ◽  
Yuhong Liu ◽  
Anson Pierce ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Muscle Mass ◽  
Mitochondrial Function ◽  
Wheel Running ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

P.1.05 Involvement of DARPP-32, FosB, and dynorphin in voluntary wheel running

2008 ◽  
Vol 18 ◽  
pp. s5-s6 ◽  
Author(s):  
A. Borgkvist ◽  
E.J. Nestler ◽  
P. Greengard ◽  
G. Fisone ◽  
S. Brené
Keyword(s):  
Wheel Running ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

Comparison of anorexia, lethargy, and fever induced by bacterial and viral mimetics in rats

2009 ◽  
Vol 87 (3) ◽  
pp. 211-220 ◽  
Author(s):  
Nicola Hopwood ◽  
Tlangelani Maswanganyi ◽  
Lois M. Harden
Keyword(s):  
Wheel Running ◽  
Poly I:C ◽  
Sprague Dawley ◽  
Voluntary Wheel Running ◽  
Polycytidylic Acid ◽  
Cage Activity ◽  
Sprague Dawley Rats ◽  
Sickness Behaviors ◽  
Saline Administration ◽  
Voluntary Wheel

Although it has been established that some acute phase responses present differently depending on whether a virus or bacteria activates the innate immune system, it has not yet been established whether fever and sickness behaviors, such as anorexia and lethargy, present differently. We therefore investigated the effects of administering lipopolysaccharide (LPS) and polyinosinic : polycytidylic acid (poly I:C) on body temperature, food intake, body mass, and activity (cage activity and wheel running). Male Sprague–Dawley rats were randomly assigned to receive an intraperitoneal injection of one of LPS (75 µg/kg or 250 µg/kg), poly I:C (3000 µg/kg or 4000 µg/kg), or saline. Administration of LPS or poly I:C induced fever, anorexia, and lethargy. Although voluntary wheel running and cage activity were both significantly reduced after administration of LPS or poly I:C, they were not affected equally. Indeed voluntary wheel running was decreased on average by approximately 30% more than cage activity regardless of the dose or type of mimetic administered. Our results indicate that poly I:C is less effective at inducing anorexia, lethargy, and fever in rats than is LPS, and that avoidance of exercise in animals and humans during infection is likely to be a more prominent feature of illness than is avoidance of routine daily activity.

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