scholarly journals Localization and function of ATP and GABA A receptors expressed by nociceptors and other postnatal sensory neurons in rat

2003 ◽  
Vol 549 (1) ◽  
pp. 131-142 ◽  
Author(s):  
Charalampos Labrakakis ◽  
Chi‐Kun Tong ◽  
Tamily Weissman ◽  
Carole Torsney ◽  
Amy B. MacDermott
Keyword(s):  
Sensory Neurons ◽  
Gaba A ◽  
And Function

scholarly journals Role of Axonal Odorant Receptors in Olfactory Topography

2020 ◽  
Vol 15 ◽  
pp. 263310552092341
Author(s):  
Claudia Lodovichi
Keyword(s):  
Olfactory Bulb ◽  
Sensory Neurons ◽  
Axon Terminal ◽  
Internal Representation ◽  
Dual Role ◽  
Odorant Receptors ◽  
Topographic Map ◽  
And Function ◽  
Guidance Molecule

A unique feature in the organization of the olfactory system is the dual role of the odorant receptors: they detect odors in the nasal epithelium and they play an instructive role in the convergence of olfactory sensory neuron axons in specific loci, ie, glomeruli, in the olfactory bulb. The dual role is corroborated by the expression of the odorant receptors in 2 specific locations of the olfactory sensory neurons: the cilia that protrude in the nostril, where the odorant receptors interact with odors, and the axon terminal, a suitable location for a potential axon guidance molecule. The mechanism of activation and function of the odorant receptors expressed at the axon terminal remained unknown for almost 20 years. A recent study identified the first putative ligand of the axonal odorant receptors, phosphatidylethanolamine-binding protein1, a molecule expressed in the olfactory bulb. The distinctive mechanisms of activation of the odorant receptors expressed at the opposite locations in sensory neurons, by odors, at the cilia, and by molecules expressed in the olfactory bulb, at the axon terminal, explain the dual role of the odorant receptors and link the specificity of odor perception with its internal representation, in the topographic map.

scholarly journals C-type natriuretic peptide is a Schwann cell-derived factor for development and function of sensory neurons

2009 ◽  
Vol 9 (S1) ◽  
Author(s):  
Ichiro Kishimoto ◽  
Takeshi Tokudome ◽  
Hideki Chusho ◽  
Kazuwa Nakao ◽  
Kenji Kangawa
Keyword(s):  
Schwann Cell ◽  
Natriuretic Peptide ◽  
Sensory Neurons ◽  
And Function

scholarly journals ASIC3 fine-tunes bladder sensory signaling

2018 ◽  
Vol 315 (4) ◽  
pp. F870-F879 ◽  
Author(s):  
Nicolas Montalbetti ◽  
James G. Rooney ◽  
Allison L. Marciszyn ◽  
Marcelo D. Carattino
Keyword(s):  
Sensory Neurons ◽  
Bladder Function ◽  
Extracellular Acidification ◽  
Acid Sensing Ion Channels ◽  
Sensory Signaling ◽  
Rate Of Decay ◽  
A Subunit ◽  
And Function ◽  
Kinetics Of

Acid-sensing ion channels (ASICs) are trimeric proton-activated, cation-selective neuronal channels that are considered to play important roles in mechanosensation and nociception. Here we investigated the role of ASIC3, a subunit primarily expressed in sensory neurons, in bladder sensory signaling and function. We found that extracellular acidification evokes a transient increase in current, consistent with the kinetics of activation and desensitization of ASICs, in ~25% of the bladder sensory neurons harvested from both wild-type (WT) and ASIC3 knockout (KO) mice. The absence of ASIC3 increased the magnitude of the peak evoked by extracellular acidification and reduced the rate of decay of the ASIC-like currents. These findings suggest that ASICs are assembled as heteromers and that the absence of ASIC3 alters the composition of these channels in bladder sensory neurons. Consistent with the notion that ASIC3 serves as a proton sensor, 59% of the bladder sensory neurons harvested from WT, but none from ASIC3 KO mice, fired action potentials in response to extracellular acidification. Studies of bladder function revealed that ASIC3 deletion reduces voiding volume and the pressure required to trigger micturition. In summary, our findings indicate that ASIC3 plays a role in the control of bladder function by modulating the response of afferents to filling.

scholarly journals Lipid Rafts Control P2X3 Receptor Distribution and Function in Trigeminal Sensory Neurons of a Transgenic Migraine Mouse Model

2011 ◽  
Vol 7 ◽  
pp. 1744-8069-7-77 ◽  
Author(s):  
Aswini Gnanasekaran ◽  
Mayya Sundukova ◽  
Arn MJM van den Maagdenberg ◽  
Elsa Fabbretti ◽  
Andrea Nistri
Keyword(s):  
Mouse Model ◽  
Lipid Rafts ◽  
Sensory Neurons ◽  
P2x3 Receptor ◽  
And Function ◽  
Receptor Distribution

Dopamine type 2 receptor expression and function in rodent sensory neurons projecting to the airways

2005 ◽  
Vol 289 (1) ◽  
pp. L153-L158 ◽  
Author(s):  
Christian Peiser ◽  
Marcello Trevisani ◽  
David A. Groneberg ◽  
Q. Thai Dinh ◽  
Doerthe Lencer ◽  
...  
Keyword(s):  
Sensory Neurons ◽  
Receptor Activation ◽  
Receptor Expression ◽  
Sensory Nerves ◽  
Plasma Extravasation ◽  
Rt Pcr ◽  
Functional Studies ◽  
And Function ◽  
Rat Trachea

Agonists of the dopamine receptors have been demonstrated to have bronchodilatory properties in pathologically constricted airways. The mechanism by which these agonists induce bronchodilatation is thought to involve airway sensory nerves. In this study, the expression and function of dopamine D2 receptor were examined in sensory ganglia supplying the airways. Neuronal dopamine D2 receptor mRNA expression was demonstrated by single-cell RT-PCR following laser-assisted microdissection. The projection of the neurons to the airways was confirmed by retrograde neuronal labeling. In functional studies, dopamine D2 receptor agonists (AR-C65116AB and ropinirole) inhibited intraneuronal calcium mobilization in rat capsaicin-sensitive primary sensory neurons and capsaicin-induced plasma extravasation in the rat trachea. Our results provide support to the hypothesis that dopamine D2 receptor activation inhibits neurogenic inflammation and proinflammatory reflex responses.

scholarly journals Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons.

1996 ◽  
Vol 271 (22) ◽  
pp. 13292
Author(s):  
Lakshmi Sangameswaran ◽  
Stephen G. Delgado ◽  
Linda M. Fish ◽  
Bruce D. Koch ◽  
Lyn B. Jakeman ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Sensory Neurons ◽  
Structure And Function ◽  
Voltage Gated ◽  
And Function
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