Release of ATP in the central nervous system during systemic inflammation: real-time measurement in the hypothalamus of conscious rabbits

The Brain-Computer Interface (BCI) is a system based on brainwaves that can be used to translate and comprehend the innumerable activities of the brain. Brainwave refers to the bioelectric impulses invariably produced in the human brain during neurotransmission, often measured as the action potential. Moreover, BCI essentially uses the widely studied Electroencephalography (EEG) technique to capture brainwave data. Paralysis generally occurs when there is a disturbance in the central nervous system prompted by a neurodegenerative or unforeseen event. To overcome the obstacles associated with paralysis, this paper on the brainwave-assistive system is based on the BCI incorporated with Internet-of-things. BCI can be implemented to achieve control over external devices and applications. For instance, the process of cursor control, motor control, neuroprosthetics and wheelchair control, etc. In this paper, the OpenBCI Cyton-biosensing board has been used for the collection of the EEG data. The accumulated EEG data is executed subsequently to obtain control over the respective systems in real-time. Hence, it can be concluded that the experiments of the paper support the idea of controlling an interfaced system through the real-time application of EEG data.

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THE LEVEL OF SYSTEMIC INFLAMMATION AND CHANGES IN ADAPTIVE IMMUNITY IN ALCOHOLIC PSYCHOSES

Medical academic journal ◽

10.17816/maj191s168-70 ◽

2019 ◽

Vol 19 (1S) ◽

pp. 68-70

Author(s):

N A Didkovsky ◽

I K Malashenkova ◽

D P Ogurtsov ◽

S A Krynskiy ◽

N A Hailov ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Adaptive Immunity ◽

Systemic Inflammation ◽

Early Period ◽

Control Group ◽

Acute Psychosis ◽

Th2 Response ◽

Proinflammatory Mediators ◽

The Central Nervous System

The aim of the work is to study the level of systemic inflammation and changes in adaptive immunity in the early period after acute psychosis to assess their participation in the pathogenesis of alcoholic mental and cognitive disorders. We examined 28 patients with alcoholic psychosis (AP) and a control group of 17 healthy volunteers. Indicators of systemic inflammation and immunity, including key cytokines and lymphocyte subpopulations, were investigated. After acute psychosis of patients with alcoholism, pronounced activation of humoral immunity with impaired clearance of immune complexes, increased content and activity of Th2 with signs of insufficiency and dysfunction of Th1, reduced content and activity of cytotoxicity system cells and signs of systemic inflammation (increased CRP, cortisol, cytokines). Activation of Th2 response and an excess of proinflammatory mediators in patients with AP through various ways of interaction with the Central nervous system (n. vagus, choroidal plexus of the ventricles, and others) can participate in the disorders of metabolism of neurotransmitters in the Central nervous system involved in the pathogenesis of alcoholism, and in the maintenance of neuroinflammation. A high level of systemic inflammation can be both a trigger of psychosis and a manifestation of violations of neuroimmune interactions, as well as the development of excitotoxicity and damage to neurons in acute psychosis.

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