scholarly journals An Origami-Based Medical Support System to Mitigate Flexible Shaft Buckling

2020 ◽  
Vol 12 (4) ◽  
Author(s):  
Brandon Sargent ◽  
Jared Butler ◽  
Kendall Seymour ◽  
David Bailey ◽  
Brian Jensen ◽  
...  
Keyword(s):  
Support System ◽  
Outer Diameter ◽  
Medical Support ◽  
Medical Robots ◽  
Flexible Shaft ◽  
Support Points ◽  
Flexible Instrument ◽  
Single Sheet ◽  
Inner Diameter ◽  
Flexible Instruments

Abstract This paper presents the development of an origami-inspired support system (the OriGuide) that enables the insertion of flexible instruments using medical robots. Varying parameters of a triangulated cylindrical origami pattern were combined to create an effective highly compressible anti-buckling system that maintains a constant inner diameter for supporting an instrument and a constant outer diameter throughout actuation. The proposed origami pattern is composed of two repeated patterns: a bistable pattern to create support points to mitigate flexible shaft buckling and a monostable pattern to enable axial extension and compression of the support system. The origami-based portion of the device is combined with two rigid mounts for interfacing with the medical robot. The origami-based portion of the device is fabricated from a single sheet of polyethylene terephthalate. The length, outer diameter, and inner diameter that emerge from the fold pattern can be customized to accommodate various robot designs and flexible instrument geometries without increasing the part count. The support system also adds protection to the instrument from external contamination.

scholarly journals Morphological Changes in Lamellar Macular Holes According to SD-OCT Examination over a Long Observation Period

Diagnostics ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1145
Author(s):  
Magdalena Kal ◽  
Izabela Chojnowska-Ćwiąkała ◽  
Mateusz Winiarczyk ◽  
Monika Jasielska ◽  
Jerzy Mackiewicz
Keyword(s):  
Retinal Thickness ◽  
Morphological Changes ◽  
Outer Diameter ◽  
Corrected Visual Acuity ◽  
Macular Holes ◽  
Kolmogorov Smirnov ◽  
Inner Diameter ◽  
Observation Period ◽  
Sd Oct

Background: The aim of this study was to evaluate the quantitative morphological changes in lamellar macular holes (LMHs) based on SD-OCT examinations and to assess the correlations among minimal retinal thickness (MRT), reading vision (RV), and best corrected visual acuity (BCVA) over a 36-month follow-up period. Methods: A group of 40 patients (44 eyes) with LMH was evaluated, with an average age of 69.87 (SD = 10.14). The quantitative parameters monitored in the follow-up period (at 0, 3, 6, 12, 18, 24, 30, and 36 months) were tested for normality of distribution by Shapiro–Wilk and Kolmogorov–Smirnov tests. Results: The RV and BCVA values were stable, and no significant changes were found at any of the check-ups during the 36-month follow-up period (BCVA p = 0.435 and RV p = 0.0999). The analysis of individual quantitative LMH parameters during the 36-month follow-up period did not demonstrate statistically significant differences: MRT (p = 0.461), Max RT temporal (p = 0.051), Max RT nasal (p = 0.364), inner diameter (ID) (p = 0.089), and outer diameter (OD) (p = 0.985). Conclusions: The observations at 0, 6, 12, 18, 24, 30, and 36 months revealed moderate and significant correlations between RV and MRT. No significant correlation between BCVA and MRT was observed.

Influence of fully submerged permanent magnets in the evaluation of heat transfer and performance analysis of single slope glass solar still

2021 ◽  
pp. 095765092110310
Author(s):  
Ajay Kumar Kaviti ◽  
Akkala Siva Ram ◽  
Amit Kumar Thakur
Keyword(s):  
Heat Transfer ◽  
Permanent Magnets ◽  
Outer Diameter ◽  
Solar Still ◽  
Transfer Coefficients ◽  
Heat Transfer Coefficients ◽  
Inner Diameter ◽  
Evaporative Heat Transfer ◽  
And Performance ◽  
Depth Water

In this experimental study, permanent magnets with three different sizes (M-1: 32 mm inner diameter, 70 mm outer diameter and 15 mm thick, M-2: 25 mm inner diameter, 60 mm outer diameter and 10 mm thick, M-3: 22 mm inner diameter, 45 mm outer diameter and 9 mm thick) are fully submerged in the single-slope glass solar still. The performance of magnetic solar stills (MSS) with three different sizes at 2 cm depth water to ensure that magnets are fully submerged is compared with conventional solar still (CSS) at the location 17.3850°N, 78.4867°E. Tiwari model is adapted to calculate the heat transfer coefficients (HTC), internal and exergy efficiencies. MSS with M-1, M-2 and M-3 significantly enhanced the convective, radiative, and evaporative heat transfer rate for the 2 cm depth of water. This is due to the desired magnetic treatment of water, which reduces the surface tension and increases the hydrogen bonds. The MSS's total internal HTC, instantaneous efficiencies led CSS by 25.52%, 28.8%, respectively, with M-1. Having various magnetic fields due to different magnets sizes increases MSS's exergetic efficiency by 33.61% with M-1, 33.76% with M-2, and 42.25% with M-3. Cumulative yield output for MSS with M-1, M-2, and M-3 is 21.66%, 17.64%, 15.78% higher than CSS. The use of permanent magnets of different sizes in the MSS is a viable, economical and straight forward technique to enhance productivity.

Self-Organized, Tubular Hybrid Vascular Tissue Composed of Vascular Cells and Collagen for Low-Pressure-Loaded Venous System

1995 ◽  
Vol 4 (6) ◽  
pp. 597-608 ◽  
Author(s):  
Jiro Hirai ◽  
Takehisa Matsuda
Keyword(s):  
Vascular Tissue ◽  
Venous System ◽  
Seeding Density ◽  
Outer Diameter ◽  
Type I ◽  
Dependent Manner ◽  
Mixed Solution ◽  
Vascular Cells ◽  
Collagen Concentration ◽  
Inner Diameter

A tubular, hierarchically structured hybrid vascular tissue composed of vascular cells and collagen was prepared. First, a cold mixed solution of bovine aortic smooth muscle cells (SMCs) and Type I collagen was poured into a tubular glass mold composed of a mandrel and a sheath (example of dimensions: inner diameter, 1.5 mm; outer diameter, 7 mm; length, 7 cm). Upon incubation at 37°C, an SMC-incorporated collagenous gel was formed. After the sheath was removed, the resulting fragile tissue, when cultured in medium, thinned in a time-dependent manner to form an opaque, dense tissue. Higher SMC seeding density and lower initial collagen concentration induced more rapid and prominent shrinkage of the tissue. Morphologic investigation showed that over time, bipolarly elongated SMCs and collagen fiber bundles became positioned around the mandrel. Both components became circumferentially oriented. When the mandrel was removed, a tubular hybrid medial tissue was formed. A hybrid vascular tissue with a hierarchical structure was constructed by seeding endothelial cells onto the inner surface of the hybrid medial tissue. Prepared tissues tolerated luminal pressures as great as 100 mmHg and mechanical stress applied during an anastomotic procedure. This method allowed us to prepare a tubular hybrid medial tissue of predetermined size (inner diameter, wail thickness, and length) by selecting appropriate mold design, initial collagen concentration, and SMC seeding density. Such hybrid vascular tissues may provide physiological functions when implanted into the venous system.

scholarly journals Evaluation of the Lower Punctum Parameters and Morphology Using Spectral Domain Anterior Segment Optical Coherence Tomography

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Riham S. H. M. Allam ◽  
Rania A. Ahmed
Keyword(s):  
Optical Coherence Tomography ◽  
Anterior Segment ◽  
Normal Subjects ◽  
Cross Sectional Study ◽  
Spectral Domain ◽  
Outer Diameter ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Air Bubble ◽  
Inner Diameter

Purpose. To study features of the lower punctum in normal subjects using spectral domain anterior segment optical coherence tomography (SD AS-OCT).Methods. Observational cross-sectional study that included 147 punctae (76 subjects). Punctae were evaluated clinically for appearance, position, and size. AS-OCT was used to evaluate the punctal shape, contents, and junction with the vertical canaliculus. Inner and outer diameters as well as depth were measured.Results. 24 males and 52 females (mean age44±14.35 y) were included. Lower punctum was perceived by OCT to be an area with an outer diameter (mean412.16±163 μm), inner diameter (mean233.67±138.73 μm), and depth (mean251.7±126.58 μm). The OCT measured outer punctum diameter was significantly less than that measured clinically (P: 0.000). Seven major shapes were identified. The junction with the vertical canaliculus was detectable in 44%. Fluid was detected in 34%, one of which had an air bubble; however, 63% of punctae showed no contents and 4% had debris.Conclusions. AS-OCT can be a useful tool in understanding the anatomy of the punctum and distal lacrimal system as well as tear drainage physiology. Measuring the punctum size may play a role in plugs fitting.

scholarly journals STUDY OF MUTAGENIC ACTIVITY NANO- AND MICROPARTICLES IN THE AMES TEST (SALMONELLA / MICROSOME)

2019 ◽  
Vol 98 (4) ◽  
pp. 455-460
Author(s):  
Lyudmila V. Akhaltseva ◽  
V. S. Zhurkov ◽  
L. P. Sycheva ◽  
O. N. Savostikova ◽  
A. V. Alekseeva
Keyword(s):  
Carbon Nanotubes ◽  
Ames Test ◽  
Mutagenic Activity ◽  
Dose Range ◽  
Gene Mutations ◽  
Outer Diameter ◽  
Multi Walled Carbon Nanotubes ◽  
Inner Diameter ◽  
Substitution Mutations ◽  
Walled Carbon Nanotubes

Introduction. One of the important steps in assessing the nanoparticles (NP) safety is the analysis of mutagenic activity, including the evaluation of gene, chromosomal, and genomic mutations. Material and methods. The purpose of this investigation is to study the ability of different NP aqueus suspensions and the same compounds in microforms to unduce gene mutations in Salmonella/microsome test (Ames test). Anatase titanium dioxide NP coated with simethicone (33.16 ± 16.7 nm, 5-50000 μg/ml), magnetite NP coated with silicate (10 nm, 0.92-575 μg/ml), silver NP coated with аrabian gum (14 ± 0.2 nm, 5-50000 μg/ml), aluminum hydroxide nanofibres (50-70 nm, 24-3000 μg/ml) and multi-walled carbon nanotubes (Taunit MWСNTs, outer diameter 15-40 nm, inner diameter 3-8 nm, length 2 and more microns, 5-50000 μg/ml). In parallel, the mutagenic activity of equivalent microparticles was evaluated in experiments. Ames test (Salmonella/microsomes) registers gene mutations induced by a different mechanism of action, in the variant with preincubation. A set of Salmonella typhimurium indicator strains: TA 100 (base pair substitution mutations), TA 98 and TA 97 (mutations of the frameshift type of the genetic code) were used. Using addition the S9 microsomal activating mixture during the experiment makes it is possible to determine the effect not only of the substances themselves, but also of their metabolites. Conclusion. The investigated nanomaterials as well as their micro analogs in the studied dose range did not induce gene mutations in the Ames test both in presence and absence microsomal activating mixture.

C60 fullerene tubes as removable templates

2006 ◽  
Vol 21 (2) ◽  
pp. 529-534 ◽  
Author(s):  
Jun-ichi Minato ◽  
Kun'ichi Miyazawa
Keyword(s):  
Methyl Alcohol ◽  
Isopropyl Alcohol ◽  
Optical Observations ◽  
C60 Fullerene ◽  
Outer Diameter ◽  
Solution Deposition ◽  
Transmission Electron ◽  
Inner Diameter ◽  
Ultrasonic Pulverization ◽  
Capillary Attraction

Crystalline microtubes (inner diameter 240–2100 nm) consisting of C60 fullerene molecules were prepared in the mixture of C60-saturated pyridine and isopropyl alcohol kept at 0 °C. Characterization by transmission electron microscopy showed a linear relationship between the outer diameter and the inner diameter for the C60 fullerene tubes. Optical observations suggested that the specimens already had tubular structure when they were grown in the solution. Deposition of guest crystals inside the C60 fullerene tubes was performed by the following procedure: (i) ultrasonic pulverization to obtain the C60 fullerene tubes with open ends, (ii) absorption of methyl alcohol solution of KBr into the tubes by the capillary attraction, and (iii) evaporation of methyl alcohol to precipitate KBr inside the tubes. Columnar KBr crystals were then obtained by dissolving the fullerene tube walls in toluene.

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