A Reduced Order Model for Spatiotemporal Dynamics and Control of Cardiac Alternans

Author(s):  
Xiaopeng Zhao ◽  
Elena G. Tolkacheva

Sudden cardiac arrest, caused primarily by ventricular fibrillation, is one of the leading causes of mortality in the Western world. There is a compelling need for risk stratification to identify patients at risk for sudden cardiac arrest. Cardiac alternans, a recognized harbinger of sudden cardiac arrest, manifests as a beat-to-beat alternation in action potential duration (cellular level) or in electrocardiogram morphology (whole heart level). Although much progress has been made to understand the mechanisms of alternans, predicting and control of alternans, especially at the heart level, remain great challenges. Current approaches to predict cardiac alternans based on restitution properties of the heart are either too simple to be valid or too complex to be useful. In this work, we developed a reduced order model from the amplitude equation to investigate dynamics and control of alternans in cardiac fiber, i.e. beyond single cell level. Detailed bifurcation and stability analyses were carried out to illustrate complex spatiotemporal patterns of alternans and the limitations in feedback control due to spatial effect.

Author(s):  
Kiyoshi Takagi ◽  
Hidekazu Nishimura

Abstract This paper deals with modeling and control of a crane mounted on a tower-like flexible structure. A fast transfer of the load causes the sway of the load rope and the vibration of the flexible structure. Our object is to control both the sway and the vibration by the inherent capability of the tower crane. This paper makes its three-dimensional models for simulation and reduced-order-model in order to design the decentralized control system. Then, we design the decentralized H∞ compensator and verify the efficiency by simulations and experiments.


Author(s):  
Sangram Redkar ◽  
S. C. Sinha

In this work, some techniques for order reduction of nonlinear systems with periodic coefficients subjected to external periodic excitations are presented. The periodicity of the linear terms is assumed to be non-commensurate with the periodicity of forcing vector. The dynamical equations of motion are transformed using the Lyapunov-Floquet (L-F) transformation such that the linear parts of the resulting equations become time-invariant while the forcing and/or nonlinearity takes the form of quasiperiodic functions. The techniques proposed here; construct a reduced order equivalent system by expressing the non-dominant states as time-varying functions of the dominant (master) states. This reduced order model preserves stability properties and is easier to analyze, simulate and control since it consists of relatively small number of states in comparison with the large scale system. Specifically, two methods are outlined to obtain the reduced order model. First approach is a straightforward application of linear method similar to the ‘Guyan reduction’, the second novel technique proposed here, utilizes the concept of ‘invariant manifolds’ for the forced problem to construct the fundamental solution. Order reduction approach based on invariant manifold technique yields unique ‘reducibility conditions’. If these ‘reducibility conditions’ are satisfied only then an accurate order reduction via ‘invariant manifold’ is possible. This approach not only yields accurate reduced order models using the fundamental solution but also explains the consequences of various ‘primary’ and ‘secondary resonances’ present in the system. One can also recover ‘resonance conditions’ associated with the fundamental solution which could be obtained via perturbation techniques by assuming weak parametric excitation. This technique is capable of handing systems with strong parametric excitations subjected to periodic and quasi-periodic forcing. These methodologies are applied to a typical problem and results for large-scale and reduced order models are compared. It is anticipated that these techniques will provide a useful tool in the analysis and control system design of large-scale parametrically excited nonlinear systems subjected to external periodic excitations.


2013 ◽  
Vol 28 (7) ◽  
pp. 3395-3404 ◽  
Author(s):  
Fabrício Hoff Dupont ◽  
Cassiano Rech ◽  
Roger Gules ◽  
José Renes Pinheiro

Author(s):  
Luis Felipe Lopez ◽  
Joseph J. Beaman

Remelting is used in the production of superalloy ingots. In these processes, stabilization of the solidification front is crucial in the prevention of segregation defects. However, models that account for solidification dynamics often are distributed-parameter multi-physics models that are not used in process control due to their complexity. This paper outlines model reduction for a remelting process based on a multi-physics finite volume model. A reduced-order model is constructed from a state-space realization where only transport phenomena are included. Balancing-free square-root singular perturbation approximation is used to construct a minimal reduced system, and then modal residualization is performed to remove modes that lie outside of the bandwidth of the actuators. The obtained reduced-order model was used to design an LQG controller. Simulation results verify that using the proposed reduced-order model for estimation and control can result in more accurate solidification control, when compared to a simplified model that accounts only for thermal processes.


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